Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis

Michelle J. Ormseth, Patricia G. Yancey, Suguru Yamamoto, Annette M. Oeser, Tebeb Gebretsadik, Ayumi Shintani, MacRae F. Linton, Sergio Fazio, Sean S. Davies, L. Jackson Roberts, Kasey C. Vickers, Paolo Raggi, Valentina Kon, C. Michael Stein

    Research output: Contribution to journalArticle

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    Abstract

    Background/objectives Cardiovascular (CV) risk is increased in patients with rheumatoid arthritis (RA), but not fully explained by traditional risk factors such as LDL and HDL cholesterol concentrations. The cholesterol efflux capacity of HDL may be a better CV risk predictor than HDL concentrations. We hypothesized that HDL's cholesterol efflux capacity is impaired and inversely associated with coronary atherosclerosis in patients with RA. Methods We measured the net cholesterol efflux capacity of apolipoprotein B depleted serum and coronary artery calcium score in 134 patients with RA and 76 control subjects, frequency-matched for age, race and sex. The relationship between net cholesterol efflux capacity and coronary artery calcium score and other clinical variables of interest was assessed in patients with RA. Results Net cholesterol efflux capacity was similar among RA (median [IQR]: 34% removal [28, 41%]) and control subjects (35% removal [27%, 39%]) (P = 0.73). In RA, increasing net cholesterol efflux capacity was not significantly associated with decreased coronary calcium score (OR = 0.78 (95% CI 0.51–1.19), P = 0.24, adjusted for age, race and sex, Framingham risk score and presence of diabetes). Net cholesterol efflux capacity was not significantly associated with RA disease activity score, C-reactive protein, urinary F2-isoprostanes, or degree of insulin resistance in RA. Conclusions Net cholesterol efflux capacity is not significantly altered in patients with relatively well-controlled RA nor is it significantly associated with coronary artery calcium score.

    Original languageEnglish (US)
    Pages (from-to)6-11
    Number of pages6
    JournalIJC Metabolic and Endocrine
    Volume13
    DOIs
    StatePublished - Dec 1 2016

    Fingerprint

    Coronary Artery Disease
    Rheumatoid Arthritis
    Cholesterol
    Serum
    Calcium
    Coronary Vessels
    HDL Cholesterol
    F2-Isoprostanes
    Apolipoproteins B
    C-Reactive Protein
    LDL Cholesterol
    Insulin Resistance

    Keywords

    • Atherosclerosis
    • Cholesterol efflux
    • HDL
    • Lipoprotein
    • Rheumatoid arthritis

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)

    Cite this

    Ormseth, M. J., Yancey, P. G., Yamamoto, S., Oeser, A. M., Gebretsadik, T., Shintani, A., ... Stein, C. M. (2016). Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis. IJC Metabolic and Endocrine, 13, 6-11. https://doi.org/10.1016/j.ijcme.2016.08.002

    Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis. / Ormseth, Michelle J.; Yancey, Patricia G.; Yamamoto, Suguru; Oeser, Annette M.; Gebretsadik, Tebeb; Shintani, Ayumi; Linton, MacRae F.; Fazio, Sergio; Davies, Sean S.; Roberts, L. Jackson; Vickers, Kasey C.; Raggi, Paolo; Kon, Valentina; Stein, C. Michael.

    In: IJC Metabolic and Endocrine, Vol. 13, 01.12.2016, p. 6-11.

    Research output: Contribution to journalArticle

    Ormseth, MJ, Yancey, PG, Yamamoto, S, Oeser, AM, Gebretsadik, T, Shintani, A, Linton, MF, Fazio, S, Davies, SS, Roberts, LJ, Vickers, KC, Raggi, P, Kon, V & Stein, CM 2016, 'Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis', IJC Metabolic and Endocrine, vol. 13, pp. 6-11. https://doi.org/10.1016/j.ijcme.2016.08.002
    Ormseth, Michelle J. ; Yancey, Patricia G. ; Yamamoto, Suguru ; Oeser, Annette M. ; Gebretsadik, Tebeb ; Shintani, Ayumi ; Linton, MacRae F. ; Fazio, Sergio ; Davies, Sean S. ; Roberts, L. Jackson ; Vickers, Kasey C. ; Raggi, Paolo ; Kon, Valentina ; Stein, C. Michael. / Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis. In: IJC Metabolic and Endocrine. 2016 ; Vol. 13. pp. 6-11.
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    abstract = "Background/objectives Cardiovascular (CV) risk is increased in patients with rheumatoid arthritis (RA), but not fully explained by traditional risk factors such as LDL and HDL cholesterol concentrations. The cholesterol efflux capacity of HDL may be a better CV risk predictor than HDL concentrations. We hypothesized that HDL's cholesterol efflux capacity is impaired and inversely associated with coronary atherosclerosis in patients with RA. Methods We measured the net cholesterol efflux capacity of apolipoprotein B depleted serum and coronary artery calcium score in 134 patients with RA and 76 control subjects, frequency-matched for age, race and sex. The relationship between net cholesterol efflux capacity and coronary artery calcium score and other clinical variables of interest was assessed in patients with RA. Results Net cholesterol efflux capacity was similar among RA (median [IQR]: 34{\%} removal [28, 41{\%}]) and control subjects (35{\%} removal [27{\%}, 39{\%}]) (P = 0.73). In RA, increasing net cholesterol efflux capacity was not significantly associated with decreased coronary calcium score (OR = 0.78 (95{\%} CI 0.51–1.19), P = 0.24, adjusted for age, race and sex, Framingham risk score and presence of diabetes). Net cholesterol efflux capacity was not significantly associated with RA disease activity score, C-reactive protein, urinary F2-isoprostanes, or degree of insulin resistance in RA. Conclusions Net cholesterol efflux capacity is not significantly altered in patients with relatively well-controlled RA nor is it significantly associated with coronary artery calcium score.",
    keywords = "Atherosclerosis, Cholesterol efflux, HDL, Lipoprotein, Rheumatoid arthritis",
    author = "Ormseth, {Michelle J.} and Yancey, {Patricia G.} and Suguru Yamamoto and Oeser, {Annette M.} and Tebeb Gebretsadik and Ayumi Shintani and Linton, {MacRae F.} and Sergio Fazio and Davies, {Sean S.} and Roberts, {L. Jackson} and Vickers, {Kasey C.} and Paolo Raggi and Valentina Kon and Stein, {C. Michael}",
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    T1 - Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis

    AU - Ormseth, Michelle J.

    AU - Yancey, Patricia G.

    AU - Yamamoto, Suguru

    AU - Oeser, Annette M.

    AU - Gebretsadik, Tebeb

    AU - Shintani, Ayumi

    AU - Linton, MacRae F.

    AU - Fazio, Sergio

    AU - Davies, Sean S.

    AU - Roberts, L. Jackson

    AU - Vickers, Kasey C.

    AU - Raggi, Paolo

    AU - Kon, Valentina

    AU - Stein, C. Michael

    PY - 2016/12/1

    Y1 - 2016/12/1

    N2 - Background/objectives Cardiovascular (CV) risk is increased in patients with rheumatoid arthritis (RA), but not fully explained by traditional risk factors such as LDL and HDL cholesterol concentrations. The cholesterol efflux capacity of HDL may be a better CV risk predictor than HDL concentrations. We hypothesized that HDL's cholesterol efflux capacity is impaired and inversely associated with coronary atherosclerosis in patients with RA. Methods We measured the net cholesterol efflux capacity of apolipoprotein B depleted serum and coronary artery calcium score in 134 patients with RA and 76 control subjects, frequency-matched for age, race and sex. The relationship between net cholesterol efflux capacity and coronary artery calcium score and other clinical variables of interest was assessed in patients with RA. Results Net cholesterol efflux capacity was similar among RA (median [IQR]: 34% removal [28, 41%]) and control subjects (35% removal [27%, 39%]) (P = 0.73). In RA, increasing net cholesterol efflux capacity was not significantly associated with decreased coronary calcium score (OR = 0.78 (95% CI 0.51–1.19), P = 0.24, adjusted for age, race and sex, Framingham risk score and presence of diabetes). Net cholesterol efflux capacity was not significantly associated with RA disease activity score, C-reactive protein, urinary F2-isoprostanes, or degree of insulin resistance in RA. Conclusions Net cholesterol efflux capacity is not significantly altered in patients with relatively well-controlled RA nor is it significantly associated with coronary artery calcium score.

    AB - Background/objectives Cardiovascular (CV) risk is increased in patients with rheumatoid arthritis (RA), but not fully explained by traditional risk factors such as LDL and HDL cholesterol concentrations. The cholesterol efflux capacity of HDL may be a better CV risk predictor than HDL concentrations. We hypothesized that HDL's cholesterol efflux capacity is impaired and inversely associated with coronary atherosclerosis in patients with RA. Methods We measured the net cholesterol efflux capacity of apolipoprotein B depleted serum and coronary artery calcium score in 134 patients with RA and 76 control subjects, frequency-matched for age, race and sex. The relationship between net cholesterol efflux capacity and coronary artery calcium score and other clinical variables of interest was assessed in patients with RA. Results Net cholesterol efflux capacity was similar among RA (median [IQR]: 34% removal [28, 41%]) and control subjects (35% removal [27%, 39%]) (P = 0.73). In RA, increasing net cholesterol efflux capacity was not significantly associated with decreased coronary calcium score (OR = 0.78 (95% CI 0.51–1.19), P = 0.24, adjusted for age, race and sex, Framingham risk score and presence of diabetes). Net cholesterol efflux capacity was not significantly associated with RA disease activity score, C-reactive protein, urinary F2-isoprostanes, or degree of insulin resistance in RA. Conclusions Net cholesterol efflux capacity is not significantly altered in patients with relatively well-controlled RA nor is it significantly associated with coronary artery calcium score.

    KW - Atherosclerosis

    KW - Cholesterol efflux

    KW - HDL

    KW - Lipoprotein

    KW - Rheumatoid arthritis

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    DO - 10.1016/j.ijcme.2016.08.002

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    JF - IJC Metabolic and Endocrine

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