Nephrotoxicity of the flame retardant, tris(2,3-dibromopropyl) phosphate, and its metabolites

W. Clayton Elliott, Robert K. Lynn, Donald Houghton, John M. Kennish, William M. Bennett

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A single ip injection of the carcinogenic flame retardant, tris(2,3-dibromopropyl) phosphate (TRIS-BP), when administered to male Sprague-Dawley rats, caused polyuric acute renal failure with tubular necrosis involving the late proximal tubule. Glomerular filtration rate and in vitro transport of the organic acid, para-aminohippurate and the organic base, N-[14C]methylnicotinamide, were depressed. An approximately equimolar dose of the TRIS-BP metabolite, bis(2,3-dibromopropyl) phosphate (BIS-BP), caused significantly more severe renal failure. In contrast, the metabolite 2,3-dibromopropanol (BP) was nonnephrotoxic. These data suggest that TRIS-BP nephrotoxicity is mediated via its metabolite BIS-BP.

Original languageEnglish (US)
Pages (from-to)179-182
Number of pages4
JournalToxicology and Applied Pharmacology
Volume62
Issue number1
DOIs
StatePublished - 1982

Fingerprint

Flame Retardants
Flame retardants
Metabolites
Glomerular Filtration Rate
Acute Kidney Injury
Renal Insufficiency
Sprague Dawley Rats
Necrosis
Injections
Acids
Organic acids
Rats
2,3-dibromopropanol
N-methylnicotinamide
bis(2,3-dibromopropyl)phosphate
In Vitro Techniques
tris(2,3-dibromopropyl)phosphate

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Nephrotoxicity of the flame retardant, tris(2,3-dibromopropyl) phosphate, and its metabolites. / Elliott, W. Clayton; Lynn, Robert K.; Houghton, Donald; Kennish, John M.; Bennett, William M.

In: Toxicology and Applied Pharmacology, Vol. 62, No. 1, 1982, p. 179-182.

Research output: Contribution to journalArticle

Elliott, W. Clayton ; Lynn, Robert K. ; Houghton, Donald ; Kennish, John M. ; Bennett, William M. / Nephrotoxicity of the flame retardant, tris(2,3-dibromopropyl) phosphate, and its metabolites. In: Toxicology and Applied Pharmacology. 1982 ; Vol. 62, No. 1. pp. 179-182.
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