Abstract
Acute and chronic nephrotoxicity frequently limits the therapeutic benefits of immunosuppressive therapy for transplant and autoimmune indications. The clinical aspects, pathophysiology, and relevant pharmacology of current and future immunosuppressive drugs are reviewed in this paper. Insights gained from experimental models of chronic nephrotoxicity associated with tubulointerstitial fibrosis are presented.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 141-145 |
| Number of pages | 5 |
| Journal | Nephrology Dialysis Transplantation |
| Volume | 9 |
| Issue number | SUPPL. 4 |
| State | Published - 1994 |
Keywords
- Cyclosporin
- FK506
- Immunosuppressive drugs
- Nephrotoxicity
- Rapamycin
ASJC Scopus subject areas
- Nephrology
- Transplantation