Nephrotoxicity of immunosuppressive drugs

W. M. Bennett, E. A. Burdmann, T. F. Andoh, Donald Houghton, J. Lindsley, L. W. Elzinga

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Abstract

Acute and chronic nephrotoxicity frequently limits the therapeutic benefits of immunosuppressive therapy for transplant and autoimmune indications. The clinical aspects, pathophysiology, and relevant pharmacology of current and future immunosuppressive drugs are reviewed in this paper. Insights gained from experimental models of chronic nephrotoxicity associated with tubulointerstitial fibrosis are presented.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalNephrology Dialysis Transplantation
Volume9
Issue numberSUPPL. 4
Publication statusPublished - 1994

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Keywords

  • Cyclosporin
  • FK506
  • Immunosuppressive drugs
  • Nephrotoxicity
  • Rapamycin

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Bennett, W. M., Burdmann, E. A., Andoh, T. F., Houghton, D., Lindsley, J., & Elzinga, L. W. (1994). Nephrotoxicity of immunosuppressive drugs. Nephrology Dialysis Transplantation, 9(SUPPL. 4), 141-145.