TY - JOUR
T1 - Nephrogenic systemic flbrosis
T2 - Incidence, associations, and effect of risk factor assessment - Report of 33 cases
AU - Perez-Rodriguez, Javier
AU - Lai, Shenghan
AU - Ehst, Benjamin D.
AU - Fine, Derek M.
AU - Bluemke, David A.
PY - 2009/2
Y1 - 2009/2
N2 - Purpose: To describe the-presentation and clinical course-of patients with nephrogenic svstemic fibrosis (NSF) at a large acute-care< 1< hospital, to evaluate the-overall incidence of NSF, and in assess the effect of a hospital-wide-policy regarding gadolinium-based contrast agent (GBCA) use on NSF incidence. Materials and Methods: A review of all cases of NSF observed at an institution from 2003 to 2008 was conducted. This HIPAA-compliant study was approved hy the institutional review board. The inFormed consent requirement was waived. Demographics, medical hislorv . and associated conditions were recorded. Radiologic procedures were evaluated if they were performed within I year prior to NSF onset. GBCA use was assessed by checking the electronic database for each procedure. The incidence of NSF was compared before and after implementation of an institutional policy designed to assess risk of NSK prior to GBCA use. Results: All 33 patients with NSF (mean age. 49 years;age range, 15-78 years) had advanced renal failure (estimated glomerular filtration rale <15 ml,/min/1.73 m< 2<) when the GBCA was injected. Twentv-six patients had severe chronic or end-stage renal disease, and seven had acute renal failure. The mean interval between contrast material injection and NSF onset was 29 davs±25 (standard deviation) (range. 4-112 davs). The overall incidence of NSF was 36.5 cases per 100 000 gadolinium-enhanced magnetic resonance (MR) examinations between 2003 and 2006 and four cases per 100 000 gadolinium-enhanced MR examinations between 2007 and 2008 alter screening for NSF risk was instituted (Fisher exact,test. P = .001). five patients developed NSF in the peritransplant period, and four underwent a catheter-based radiographic procedure with administration of a GBCA. Conclusion: Common associations of GBCA MR imaging and NSF were acute and severe chronic-renal failure and liver or renal transplantation. Screening procedures performed before MR imaging to determine which patients were at risk of developing NSF' appear to reduce the incidence of this complication and further support the belief that NSF is associated with GBCA administration.
AB - Purpose: To describe the-presentation and clinical course-of patients with nephrogenic svstemic fibrosis (NSF) at a large acute-care< 1< hospital, to evaluate the-overall incidence of NSF, and in assess the effect of a hospital-wide-policy regarding gadolinium-based contrast agent (GBCA) use on NSF incidence. Materials and Methods: A review of all cases of NSF observed at an institution from 2003 to 2008 was conducted. This HIPAA-compliant study was approved hy the institutional review board. The inFormed consent requirement was waived. Demographics, medical hislorv . and associated conditions were recorded. Radiologic procedures were evaluated if they were performed within I year prior to NSF onset. GBCA use was assessed by checking the electronic database for each procedure. The incidence of NSF was compared before and after implementation of an institutional policy designed to assess risk of NSK prior to GBCA use. Results: All 33 patients with NSF (mean age. 49 years;age range, 15-78 years) had advanced renal failure (estimated glomerular filtration rale <15 ml,/min/1.73 m< 2<) when the GBCA was injected. Twentv-six patients had severe chronic or end-stage renal disease, and seven had acute renal failure. The mean interval between contrast material injection and NSF onset was 29 davs±25 (standard deviation) (range. 4-112 davs). The overall incidence of NSF was 36.5 cases per 100 000 gadolinium-enhanced magnetic resonance (MR) examinations between 2003 and 2006 and four cases per 100 000 gadolinium-enhanced MR examinations between 2007 and 2008 alter screening for NSF risk was instituted (Fisher exact,test. P = .001). five patients developed NSF in the peritransplant period, and four underwent a catheter-based radiographic procedure with administration of a GBCA. Conclusion: Common associations of GBCA MR imaging and NSF were acute and severe chronic-renal failure and liver or renal transplantation. Screening procedures performed before MR imaging to determine which patients were at risk of developing NSF' appear to reduce the incidence of this complication and further support the belief that NSF is associated with GBCA administration.
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U2 - 10.1148/radiol.2502080498
DO - 10.1148/radiol.2502080498
M3 - Article
C2 - 19188312
AN - SCOPUS:61749102915
SN - 0033-8419
VL - 250
SP - 371
EP - 377
JO - RADIOLOGY
JF - RADIOLOGY
IS - 2
ER -