Neoplastic transformation in vitro of hamster lens epithelium by simian virus 40

Daniel Albert, Alan S. Rabson, Patricia A. Grimes, Ludwig Von Sallmann

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Hamster lens epithelium infected with simian virus 40 underwent transformation in vitro and produced tumors when injected into homologous hosts. Undisturbed lens epithelium in man and experimental animals has not been observed to undergo neoplastic change. The virus-induced tumors contained undifferentiated cells that were either polygonal or spindle-shaped. Their origin from lens epithelium seems certain since it is possible to isolate this unique structure free of connective tissue and blood vessels.

Original languageEnglish (US)
Pages (from-to)1077-1078
Number of pages2
JournalScience
Volume164
Issue number3883
DOIs
StatePublished - Jan 1 1969
Externally publishedYes

Fingerprint

Simian virus 40
Cricetinae
Lenses
Epithelium
Oncogenic Viruses
Connective Tissue
Blood Vessels
In Vitro Techniques
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Neoplastic transformation in vitro of hamster lens epithelium by simian virus 40. / Albert, Daniel; Rabson, Alan S.; Grimes, Patricia A.; Von Sallmann, Ludwig.

In: Science, Vol. 164, No. 3883, 01.01.1969, p. 1077-1078.

Research output: Contribution to journalArticle

Albert, Daniel ; Rabson, Alan S. ; Grimes, Patricia A. ; Von Sallmann, Ludwig. / Neoplastic transformation in vitro of hamster lens epithelium by simian virus 40. In: Science. 1969 ; Vol. 164, No. 3883. pp. 1077-1078.
@article{32c16c6ac12a47d3bf742417027e5401,
title = "Neoplastic transformation in vitro of hamster lens epithelium by simian virus 40",
abstract = "Hamster lens epithelium infected with simian virus 40 underwent transformation in vitro and produced tumors when injected into homologous hosts. Undisturbed lens epithelium in man and experimental animals has not been observed to undergo neoplastic change. The virus-induced tumors contained undifferentiated cells that were either polygonal or spindle-shaped. Their origin from lens epithelium seems certain since it is possible to isolate this unique structure free of connective tissue and blood vessels.",
author = "Daniel Albert and Rabson, {Alan S.} and Grimes, {Patricia A.} and {Von Sallmann}, Ludwig",
year = "1969",
month = "1",
day = "1",
doi = "10.1126/science.164.3883.1077",
language = "English (US)",
volume = "164",
pages = "1077--1078",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "3883",

}

TY - JOUR

T1 - Neoplastic transformation in vitro of hamster lens epithelium by simian virus 40

AU - Albert, Daniel

AU - Rabson, Alan S.

AU - Grimes, Patricia A.

AU - Von Sallmann, Ludwig

PY - 1969/1/1

Y1 - 1969/1/1

N2 - Hamster lens epithelium infected with simian virus 40 underwent transformation in vitro and produced tumors when injected into homologous hosts. Undisturbed lens epithelium in man and experimental animals has not been observed to undergo neoplastic change. The virus-induced tumors contained undifferentiated cells that were either polygonal or spindle-shaped. Their origin from lens epithelium seems certain since it is possible to isolate this unique structure free of connective tissue and blood vessels.

AB - Hamster lens epithelium infected with simian virus 40 underwent transformation in vitro and produced tumors when injected into homologous hosts. Undisturbed lens epithelium in man and experimental animals has not been observed to undergo neoplastic change. The virus-induced tumors contained undifferentiated cells that were either polygonal or spindle-shaped. Their origin from lens epithelium seems certain since it is possible to isolate this unique structure free of connective tissue and blood vessels.

UR - http://www.scopus.com/inward/record.url?scp=0014695548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014695548&partnerID=8YFLogxK

U2 - 10.1126/science.164.3883.1077

DO - 10.1126/science.164.3883.1077

M3 - Article

C2 - 4306014

AN - SCOPUS:0014695548

VL - 164

SP - 1077

EP - 1078

JO - Science

JF - Science

SN - 0036-8075

IS - 3883

ER -