Neonatal necrotizing enterocolitis. A 10 year experience

John R. Gregory, John R. Campbell, Marvin W. Harrison, Timothy J. Campbell

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Neonatal necrotizing enterocolitis was seen in 42 of 5,030 infants (0.83 percent) admitted to our neonatal intensive care units. The condition developed more than 1 week after birth in most infants. This group included most of the very low birth weight infants. Forty-one of the 42 infants had enterai feedings before the onset of enterocolitis, which developed within 72 hours from the start of feedings in 19 infants (45 percent). Twenty-nine patients (69 percent) underwent surgery. Mortality in this group was 38 percent overall and 28 percent in the infants considered salvageable at laparotomy. The interval from diagnosis to surgery was 24 hours or less in 65 percent of cases, emphasizing the fulminant nature of the disease in many patients. Three of the 14 patients who died underwent no surgery. Pneumoperitoneum was one of the initial radiologie signs in 10 patients (24 percent). The necrotizing enterocolitis observed was similar clinically to that reported by others. The strikingly low incidence of enterocolitis in the neonatal intensive care units in Oregon (0.83 percent) contrasts with the generally reported incidence of 3 to 8 percent in other neonatal intensive care units. We attribute the low incidence of necrotizing enterocolitis in our experience to delay of enterai feedings and reliance on prolonged peripheral or central total parenteral nutrition, or both, for nutritional maintenance of stressed or low birth weight infants.

Original languageEnglish (US)
Pages (from-to)562-567
Number of pages6
JournalThe American Journal of Surgery
Volume141
Issue number5
DOIs
StatePublished - 1981

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Necrotizing Enterocolitis
Neonatal Intensive Care Units
Enterocolitis
Incidence
Very Low Birth Weight Infant
Pneumoperitoneum
Total Parenteral Nutrition
Low Birth Weight Infant
Laparotomy
Maintenance
Parturition
Mortality

ASJC Scopus subject areas

  • Surgery

Cite this

Gregory, J. R., Campbell, J. R., Harrison, M. W., & Campbell, T. J. (1981). Neonatal necrotizing enterocolitis. A 10 year experience. The American Journal of Surgery, 141(5), 562-567. https://doi.org/10.1016/0002-9610(81)90049-0

Neonatal necrotizing enterocolitis. A 10 year experience. / Gregory, John R.; Campbell, John R.; Harrison, Marvin W.; Campbell, Timothy J.

In: The American Journal of Surgery, Vol. 141, No. 5, 1981, p. 562-567.

Research output: Contribution to journalArticle

Gregory, JR, Campbell, JR, Harrison, MW & Campbell, TJ 1981, 'Neonatal necrotizing enterocolitis. A 10 year experience', The American Journal of Surgery, vol. 141, no. 5, pp. 562-567. https://doi.org/10.1016/0002-9610(81)90049-0
Gregory, John R. ; Campbell, John R. ; Harrison, Marvin W. ; Campbell, Timothy J. / Neonatal necrotizing enterocolitis. A 10 year experience. In: The American Journal of Surgery. 1981 ; Vol. 141, No. 5. pp. 562-567.
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