Neonatal medical admission in a term and late-preterm cohort exposed to magnesium sulfate

Mara B. Greenberg, Anna A. Penn, Lewis J. Thomas, Yasser Y. El-Sayed, Aaron B. Caughey, Deirdre J. Lyell

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective: The purpose of this study was to estimate neonatal intensive care unit and special care unit (NICU) admission rates and care needs among term and late-preterm neonates who are exposed to antenatal magnesium sulfate. Study Design: We conducted a retrospective cohort study of all singleton neonates of <35 weeks' gestation who were exposed immediately antenatally to magnesium sulfate for maternal eclampsia prophylaxis (August 2006 through July 2008). Results: Fifty-one of 242 neonates (21.1%) who, at <35 weeks' gestation, had been exposed to antenatal magnesium sulfate were admitted to the NICU. NICU admission was associated in a dose-dependent fashion with total hours and mean dose of magnesium: >12 hours exposure, odds ratio, 2.81 (95% confidence interval, 1.316.03); >30 g exposure, odds ratio, 2.59 (95% confidence interval, 1.225.51). Infants in NICU who were diagnosed with hypermagnesemia required fluid or nutritional support more frequently (91.3% vs 39.3%; P < .001) than those without hypermagnesemia. Conclusion: Antenatal magnesium sulfate exposure is associated with NICU admission among term and late-preterm neonates in a dose-dependent fashion. Fluid and nutritional assistance commonly are needed in this cohort.

Original languageEnglish (US)
Pages (from-to)515.e1-515.e7
JournalAmerican journal of obstetrics and gynecology
Issue number6
StatePublished - Jun 2011


  • antenatal
  • magnesium sulfate exposure
  • neonatal effect

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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