Neonatal leukocyte cAMP‐phosphodiesterase determination is not suitable for allergy prediction

H. Odelram, B. Björksten, S. C. Chan, J. M. Hanifin, N. ‐I M. Kjellman

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The atopy‐predictive value of cord blood (CB) cyclic adenosine monophosphate‐phosphodiesterase (cAMP‐PDE) in mononuclear leukocytes (MN) was studied prospectively in 57 neonates. Reliable determination of cAMP‐PDE was achieved in only 20 CB samples. The levels tended to be higher in infants developing signs of atopy up to 18 months of age. The combination of CB cAMP‐PDE and family history (FH) of allergy showed a higher predictive value (P = 0.040) than each of them separately (P= 0.370 and P= 0.102, respectively). The cAMP‐PDE levels in CB also correlated to FH of allergy/atopy in accordance with earlier studies (P = 0.027). In conclusion, determination of cAMP‐PDE in neonates may have some predictive value, but it is not suitable for general screening.

Original languageEnglish (US)
Pages (from-to)677-679
Number of pages3
JournalAllergy
Volume49
Issue number8
DOIs
StatePublished - Sep 1994

Keywords

  • allergy
  • cAMP‐phosphodiesterase
  • infants
  • neonatal screening tests
  • prediction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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