Hypopituitary hypothyroidism was found in an infant born to a mother with inadequately treated thyrotoxicosis. The infant had low thyroxine (T4), low free T4, and diminished thyroid-stimulating hormone (TSH) levels with a blunted response to thyrotropin-releasing hormone (TRH) stimulation until 6 weeks of age when thyroid hormone replacement was started. Excess fetal thyroid hormone may have caused an alteration in TSH secretory dynamics leading to the development of neonatal hypopituitary hypothyroidism.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Endocrinology, Diabetes and Metabolism