Neocortical damage during HIV infection

Clayton A. Wiley, Eliezer Masliah, Mitchel Morey, Cindy Lemere, Richard DeTeresa, Marjorie Grafe, Lawrence Hansen, Robert Terry

Research output: Contribution to journalArticlepeer-review

436 Scopus citations


Clinical and pathologicals evidence of subcortical central nervous system (CNS) damage is observed commonly in patients with human immunodeficiency virus (HIV) encephalitis. Whether other CNS regions are also affected has not been well studied. We report neocortical damage in patients with HIV encephalitis. Using quantitative techniques, we demonstrate statistically significant thinning of the neocortex, with a loss of large cortical neurons. Qualitative and quantitative assessments of neocortical neuropil reveal a loss of synaptic density and vacuolation of dendritic processes. Failure to demonstrate an association of these changes with the presence of HIV antigens suggests that neocortical damage may be an indirect effect of HIV infection of the CNS.

Original languageEnglish (US)
Pages (from-to)651-657
Number of pages7
JournalAnnals of Neurology
Issue number6
StatePublished - Jun 1991
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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