Abstract
Large, adrenocorticotrophic hormone-secreting pituitary tumors (Nelson's syndrome) developed in four of 12 patients treated with a bilateral adrenalectomy for Cushing's disease. Two of the patients with Nelson's syndrome suffered spontaneous pituitary tumor infarctions. One patient improved under close observation and subsequent radiation therapy, although she ultimately died from her locally invasive tumor. The condition of the other patient—which had stabilized—appeared to be worsened by surgical intervention. The high incidence of these tumors after bilateral adrenalectomy, their large and aggressive nature, and their apparent propensity to undergo spontaneous infarction supports the position that initial therapy for Cushing's disease should be directed to the pituitary gland.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 340-342 |
| Number of pages | 3 |
| Journal | Archives of Internal Medicine |
| Volume | 139 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1979 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Internal Medicine
Cite this
Nelson's Syndrome and Spontaneous Pituitary Tumor Infarction. / Jordan, Richard M.; Cook, David M.; Kendall, John; Kerber, Charles W.
In: Archives of Internal Medicine, Vol. 139, No. 3, 1979, p. 340-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nelson's Syndrome and Spontaneous Pituitary Tumor Infarction
AU - Jordan, Richard M.
AU - Cook, David M.
AU - Kendall, John
AU - Kerber, Charles W.
PY - 1979
Y1 - 1979
N2 - Large, adrenocorticotrophic hormone-secreting pituitary tumors (Nelson's syndrome) developed in four of 12 patients treated with a bilateral adrenalectomy for Cushing's disease. Two of the patients with Nelson's syndrome suffered spontaneous pituitary tumor infarctions. One patient improved under close observation and subsequent radiation therapy, although she ultimately died from her locally invasive tumor. The condition of the other patient—which had stabilized—appeared to be worsened by surgical intervention. The high incidence of these tumors after bilateral adrenalectomy, their large and aggressive nature, and their apparent propensity to undergo spontaneous infarction supports the position that initial therapy for Cushing's disease should be directed to the pituitary gland.
AB - Large, adrenocorticotrophic hormone-secreting pituitary tumors (Nelson's syndrome) developed in four of 12 patients treated with a bilateral adrenalectomy for Cushing's disease. Two of the patients with Nelson's syndrome suffered spontaneous pituitary tumor infarctions. One patient improved under close observation and subsequent radiation therapy, although she ultimately died from her locally invasive tumor. The condition of the other patient—which had stabilized—appeared to be worsened by surgical intervention. The high incidence of these tumors after bilateral adrenalectomy, their large and aggressive nature, and their apparent propensity to undergo spontaneous infarction supports the position that initial therapy for Cushing's disease should be directed to the pituitary gland.
UR - http://www.scopus.com/inward/record.url?scp=0018591936&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018591936&partnerID=8YFLogxK
U2 - 10.1001/archinte.1979.03630400056021
DO - 10.1001/archinte.1979.03630400056021
M3 - Article
C2 - 426579
AN - SCOPUS:0018591936
VL - 139
SP - 340
EP - 342
JO - JAMA Internal Medicine
JF - JAMA Internal Medicine
SN - 2168-6106
IS - 3
ER -