Necrotizing arterial lesions in mice-bearing tumors induced by polyoma virus.

C. J. Dawe, R. Freund, J. P. Barncastle, T. W. Dubensky, Gail Mandel, T. L. Benjamin

Research output: Contribution to journalArticle

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Abstract

In the course of determining tumor profiles for wild-type and recombinant mouse polyoma viruses (MPyV's), we fortuitously discovered two types of necrotizing arterial disease in polyoma tumor-bearing C3H/BiDa mice. One type, designated BLAND, consisted of foci of necrosis unaccompanied by inflammatory reaction, in the muscular coat of aorta, pulmonary arterial trunk, and primary or occasionally secondary branches of these vessels. BLAND lesions contained MPyV capsid antigen VP1 as shown by immunocytochemistry, and appeared to be the result of viral cytolytic infection within artery walls. Lesions of the second type are designated PANoid in view of their resemblance to polyarteritis nodosa in humans. PANoid lesions had much the same distribution in the arterial tree as BLAND lesions and were also focal, but had the histologic properties of highly destructive acute inflammatory reactions. Specifically, there were dense infiltrations of polymorphonuclear leukocytes in any and often all coats of the arterial wall, acute fibrinoid necrosis, endothelial proliferations, intravascular thrombosis, and in one example, rupture of the intimal and medial coats with microaneurysm formation. In the acute phase, PANoid lesions exhibited attenuation, fragmentation, and loss of elastic laminae, and in the healing phase, intimal and medial fibrosis with varying degrees of lumenal occlusion. PANoid lesions gave negative immunocytochemical reactions for MPyV capsid antigen VP1, indicating either that the antigen was not present, or that it was masked in complexes with antibody and C3. BLAND lesions were found in 51% of 459 MPyV-infected mice, while PANoid lesions were found in 11%. There was no sex predilection for either type lesion, and practically all mice with lesions fell within ages 60-200 days. We suspect the PANoid lesions are examples of immune-complex arteritis related to persistent MPyV infection, but support for this hypothesis is presently tenuous, resting entirely on the coexistence of BLAND and PANoid lesions in MPyV-infected mice and the histological resemblance of PANoid lesions to naturally occurring and experimentally induced immune complex arteritis.

Original languageEnglish (US)
Pages (from-to)177-201
Number of pages25
JournalJournal of experimental pathology
Volume3
Issue number2
StatePublished - Mar 1987
Externally publishedYes

Fingerprint

Polyomavirus
Neoplasms
Tunica Intima
Arteritis
Virus Diseases
Antigen-Antibody Complex
Necrosis
Polyarteritis Nodosa
Inbred C3H Mouse
Aorta
Rupture
Neutrophils
Thrombosis
Fibrosis
Arteries
Immunohistochemistry
Antigens
Lung
Antibodies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Dawe, C. J., Freund, R., Barncastle, J. P., Dubensky, T. W., Mandel, G., & Benjamin, T. L. (1987). Necrotizing arterial lesions in mice-bearing tumors induced by polyoma virus. Journal of experimental pathology, 3(2), 177-201.

Necrotizing arterial lesions in mice-bearing tumors induced by polyoma virus. / Dawe, C. J.; Freund, R.; Barncastle, J. P.; Dubensky, T. W.; Mandel, Gail; Benjamin, T. L.

In: Journal of experimental pathology, Vol. 3, No. 2, 03.1987, p. 177-201.

Research output: Contribution to journalArticle

Dawe, CJ, Freund, R, Barncastle, JP, Dubensky, TW, Mandel, G & Benjamin, TL 1987, 'Necrotizing arterial lesions in mice-bearing tumors induced by polyoma virus.', Journal of experimental pathology, vol. 3, no. 2, pp. 177-201.
Dawe CJ, Freund R, Barncastle JP, Dubensky TW, Mandel G, Benjamin TL. Necrotizing arterial lesions in mice-bearing tumors induced by polyoma virus. Journal of experimental pathology. 1987 Mar;3(2):177-201.
Dawe, C. J. ; Freund, R. ; Barncastle, J. P. ; Dubensky, T. W. ; Mandel, Gail ; Benjamin, T. L. / Necrotizing arterial lesions in mice-bearing tumors induced by polyoma virus. In: Journal of experimental pathology. 1987 ; Vol. 3, No. 2. pp. 177-201.
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abstract = "In the course of determining tumor profiles for wild-type and recombinant mouse polyoma viruses (MPyV's), we fortuitously discovered two types of necrotizing arterial disease in polyoma tumor-bearing C3H/BiDa mice. One type, designated BLAND, consisted of foci of necrosis unaccompanied by inflammatory reaction, in the muscular coat of aorta, pulmonary arterial trunk, and primary or occasionally secondary branches of these vessels. BLAND lesions contained MPyV capsid antigen VP1 as shown by immunocytochemistry, and appeared to be the result of viral cytolytic infection within artery walls. Lesions of the second type are designated PANoid in view of their resemblance to polyarteritis nodosa in humans. PANoid lesions had much the same distribution in the arterial tree as BLAND lesions and were also focal, but had the histologic properties of highly destructive acute inflammatory reactions. Specifically, there were dense infiltrations of polymorphonuclear leukocytes in any and often all coats of the arterial wall, acute fibrinoid necrosis, endothelial proliferations, intravascular thrombosis, and in one example, rupture of the intimal and medial coats with microaneurysm formation. In the acute phase, PANoid lesions exhibited attenuation, fragmentation, and loss of elastic laminae, and in the healing phase, intimal and medial fibrosis with varying degrees of lumenal occlusion. PANoid lesions gave negative immunocytochemical reactions for MPyV capsid antigen VP1, indicating either that the antigen was not present, or that it was masked in complexes with antibody and C3. BLAND lesions were found in 51{\%} of 459 MPyV-infected mice, while PANoid lesions were found in 11{\%}. There was no sex predilection for either type lesion, and practically all mice with lesions fell within ages 60-200 days. We suspect the PANoid lesions are examples of immune-complex arteritis related to persistent MPyV infection, but support for this hypothesis is presently tenuous, resting entirely on the coexistence of BLAND and PANoid lesions in MPyV-infected mice and the histological resemblance of PANoid lesions to naturally occurring and experimentally induced immune complex arteritis.",
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