Navigating the phenotype frontier

The monarch initiative

Julie A. McMurry, Sebastian Köhler, Nicole L. Washington, James P. Balhoff, Charles Borromeo, Matthew Brush, Seth Carbon, Tom Conlin, Nathan Dunn, Mark Engelstad, Erin Foster, Jean Philippe Gourdine, Julius O B Jacobsen, Daniel Keith, Bryan Laraway, Jeremy Nguyen Xuan, Kent Shefchek, Nicole A. Vasilevsky, Zhou Yuan, Suzanna E. Lewis & 6 others Harry Hochheiser, Tudor Groza, Damian Smedley, Peter N. Robinson, Christopher J. Mungall, Melissa Haendel

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The principles of genetics apply across the entire tree of life. At the cellular level we share biological mechanisms with species from which we diverged millions, even billions of years ago. We can exploit this common ancestry to learn about health and disease, by analyzing DNA and protein sequences, but also through the observable outcomes of genetic differences, i.e. phenotypes. To solve challenging disease problems we need to unify the heterogeneous data that relates genomics to disease traits. Without a big-picture view of phenotypic data, many questions in genetics are difficult or impossible to answer. The Monarch Initiative (https://monarchinitiative.org) provides tools for genotype-phenotype analysis, genomic diagnostics, and precision medicine across broad areas of disease.

Original languageEnglish (US)
Pages (from-to)1491-1495
Number of pages5
JournalGenetics
Volume203
Issue number4
DOIs
StatePublished - Aug 1 2016

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Phenotype
Precision Medicine
Genomics
Genotype
Health
Proteins

Keywords

  • Comparative medicine
  • Data integration
  • Disease diagnosis
  • Disease discovery
  • Phenotype ontologies

ASJC Scopus subject areas

  • Genetics

Cite this

McMurry, J. A., Köhler, S., Washington, N. L., Balhoff, J. P., Borromeo, C., Brush, M., ... Haendel, M. (2016). Navigating the phenotype frontier: The monarch initiative. Genetics, 203(4), 1491-1495. https://doi.org/10.1534/genetics.116.188870

Navigating the phenotype frontier : The monarch initiative. / McMurry, Julie A.; Köhler, Sebastian; Washington, Nicole L.; Balhoff, James P.; Borromeo, Charles; Brush, Matthew; Carbon, Seth; Conlin, Tom; Dunn, Nathan; Engelstad, Mark; Foster, Erin; Gourdine, Jean Philippe; Jacobsen, Julius O B; Keith, Daniel; Laraway, Bryan; Xuan, Jeremy Nguyen; Shefchek, Kent; Vasilevsky, Nicole A.; Yuan, Zhou; Lewis, Suzanna E.; Hochheiser, Harry; Groza, Tudor; Smedley, Damian; Robinson, Peter N.; Mungall, Christopher J.; Haendel, Melissa.

In: Genetics, Vol. 203, No. 4, 01.08.2016, p. 1491-1495.

Research output: Contribution to journalArticle

McMurry, JA, Köhler, S, Washington, NL, Balhoff, JP, Borromeo, C, Brush, M, Carbon, S, Conlin, T, Dunn, N, Engelstad, M, Foster, E, Gourdine, JP, Jacobsen, JOB, Keith, D, Laraway, B, Xuan, JN, Shefchek, K, Vasilevsky, NA, Yuan, Z, Lewis, SE, Hochheiser, H, Groza, T, Smedley, D, Robinson, PN, Mungall, CJ & Haendel, M 2016, 'Navigating the phenotype frontier: The monarch initiative', Genetics, vol. 203, no. 4, pp. 1491-1495. https://doi.org/10.1534/genetics.116.188870
McMurry JA, Köhler S, Washington NL, Balhoff JP, Borromeo C, Brush M et al. Navigating the phenotype frontier: The monarch initiative. Genetics. 2016 Aug 1;203(4):1491-1495. https://doi.org/10.1534/genetics.116.188870
McMurry, Julie A. ; Köhler, Sebastian ; Washington, Nicole L. ; Balhoff, James P. ; Borromeo, Charles ; Brush, Matthew ; Carbon, Seth ; Conlin, Tom ; Dunn, Nathan ; Engelstad, Mark ; Foster, Erin ; Gourdine, Jean Philippe ; Jacobsen, Julius O B ; Keith, Daniel ; Laraway, Bryan ; Xuan, Jeremy Nguyen ; Shefchek, Kent ; Vasilevsky, Nicole A. ; Yuan, Zhou ; Lewis, Suzanna E. ; Hochheiser, Harry ; Groza, Tudor ; Smedley, Damian ; Robinson, Peter N. ; Mungall, Christopher J. ; Haendel, Melissa. / Navigating the phenotype frontier : The monarch initiative. In: Genetics. 2016 ; Vol. 203, No. 4. pp. 1491-1495.
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