Navigating the phenotype frontier: The monarch initiative

Julie A. McMurry; Sebastian Köhler; Nicole L. Washington; James P. Balhoff; Charles Borromeo; Matthew Brush; Seth Carbon; Tom Conlin; Nathan Dunn; Mark Engelstad; Erin Foster; Jean Philippe Gourdine; Julius O.B. Jacobsen; Daniel Keith; Bryan Laraway; Jeremy Nguyen Xuan; Kent Shefchek; Nicole A. Vasilevsky; Zhou Yuan; Suzanna E. Lewis; Harry Hochheiser; Tudor Groza; Damian Smedley; Peter N. Robinson; Christopher J. Mungall; Melissa A. Haendel

doi:10.1534/genetics.116.188870

Navigating the phenotype frontier: The monarch initiative

Julie A. McMurry, Sebastian Köhler, Nicole L. Washington, James P. Balhoff, Charles Borromeo, Matthew Brush, Seth Carbon, Tom Conlin, Nathan Dunn, Mark Engelstad, Erin Foster, Jean Philippe Gourdine, Julius O.B. Jacobsen, Daniel Keith, Bryan Laraway, Jeremy Nguyen Xuan, Kent Shefchek, Nicole A. Vasilevsky, Zhou Yuan, Suzanna E. LewisHarry Hochheiser, Tudor Groza, Damian Smedley, Peter N. Robinson, Christopher J. Mungall, Melissa A. Haendel

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

The principles of genetics apply across the entire tree of life. At the cellular level we share biological mechanisms with species from which we diverged millions, even billions of years ago. We can exploit this common ancestry to learn about health and disease, by analyzing DNA and protein sequences, but also through the observable outcomes of genetic differences, i.e. phenotypes. To solve challenging disease problems we need to unify the heterogeneous data that relates genomics to disease traits. Without a big-picture view of phenotypic data, many questions in genetics are difficult or impossible to answer. The Monarch Initiative (https://monarchinitiative.org) provides tools for genotype-phenotype analysis, genomic diagnostics, and precision medicine across broad areas of disease.

Original language	English (US)
Pages (from-to)	1491-1495
Number of pages	5
Journal	Genetics
Volume	203
Issue number	4
DOIs	https://doi.org/10.1534/genetics.116.188870
State	Published - Aug 2016

Keywords

Comparative medicine
Data integration
Disease diagnosis
Disease discovery
Phenotype ontologies

ASJC Scopus subject areas

General Medicine

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10.1534/genetics.116.188870

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McMurry, J. A., Köhler, S., Washington, N. L., Balhoff, J. P., Borromeo, C., Brush, M., Carbon, S., Conlin, T., Dunn, N., Engelstad, M., Foster, E., Gourdine, J. P., Jacobsen, J. O. B., Keith, D., Laraway, B., Xuan, J. N., Shefchek, K., Vasilevsky, N. A., Yuan, Z., ... Haendel, M. A. (2016). Navigating the phenotype frontier: The monarch initiative. Genetics, 203(4), 1491-1495. https://doi.org/10.1534/genetics.116.188870

McMurry, JA, Köhler, S, Washington, NL, Balhoff, JP, Borromeo, C, Brush, M, Carbon, S, Conlin, T, Dunn, N, Engelstad, M, Foster, E, Gourdine, JP, Jacobsen, JOB, Keith, D, Laraway, B, Xuan, JN, Shefchek, K, Vasilevsky, NA, Yuan, Z, Lewis, SE, Hochheiser, H, Groza, T, Smedley, D, Robinson, PN, Mungall, CJ & Haendel, MA 2016, 'Navigating the phenotype frontier: The monarch initiative', Genetics, vol. 203, no. 4, pp. 1491-1495. https://doi.org/10.1534/genetics.116.188870

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AU - Hochheiser, Harry

AU - Groza, Tudor

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Navigating the phenotype frontier: The monarch initiative

Abstract

Keywords

ASJC Scopus subject areas

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