Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors

Lydia W.T. Cheung, Shuangxing Yu, Dong Zhang, Jie Li, Patrick K.S. Ng, Nattapon Panupinthu, Shreya Mitra, Zhenlin Ju, Qinghua Yu, Han Liang, David H. Hawke, Yiling Lu, Russell R. Broaddus, Gordon B. Mills

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Medicine & Life Sciences