Naturally occurring cardiomyopathy in the Doberman pinscher: A possible large animal model of human cardiomyopathy?

Mark L. Smucker, Sanjiv Kaul, Jerry A. Woodfield, James C. Keith, Scott A. Manning, Joseph A. Gascho

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Currently there is no large animal model of dilated cardiomyopathy. The smaller animal models of cardiomyopathy, such as the Syrian hamster, cannot be studied with echocartography and cardiac catheterization, and the relevance of these models to human dilated cardiomyopathy is open to question. On the basis of some initial observations in Doberman pinschers, it was speculated that these dogs could have occult left ventricular dysfunction. Accordingly, studies were performed in 46 apparently healthy Doberman pinschers and in 41 mongrel dogs: two-dimensional echocardiography (30 dogs in each group), cardiac catheterization (16 Doberman pinschers and 12 mongrels) and coronary blood flow studies (13 Doberman pinschers and 6 mongrels). In the awake, unsedated dogs studied with echocardiography, left ventricular wall thickening was significantly less in the Dobermans than in the mongrels (28% versus 36%, p = 0.0003). In the anesthetized dogs undergoing cardiac catheterization, left ventricular ejection fraction was significantly lower in the Dobermans than in the mongrels (0.38 versus 0.63, p = 0.0001). Rest coronary blood flow and coronary blood flow reserve were similar in the two groups. It is concluded that apparently healthy Doberman pinschers have occult left ventricular dysfunction. These dogs may serve as a large animal model of dilated cardiomyopathy and should not be used experimentally to study normal cardiac physiology.

Original languageEnglish (US)
Pages (from-to)200-206
Number of pages7
JournalJournal of the American College of Cardiology
Volume16
Issue number1
DOIs
StatePublished - Jul 1990
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Naturally occurring cardiomyopathy in the Doberman pinscher: A possible large animal model of human cardiomyopathy?'. Together they form a unique fingerprint.

Cite this