Naturalistic behavioral assessment of anxiolytic properties of benzodiazepines and ethanol in mice

Bruce C. Dudek; Angela Maio; Tamara J. Phillips; Mark Perrone

doi:10.1016/0304-3940(86)90367-8

Naturalistic behavioral assessment of anxiolytic properties of benzodiazepines and ethanol in mice

Bruce C. Dudek, Angela Maio, Tamara J. Phillips, Mark Perrone

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Effects of chlordiazepoxide (CDZ), flurazepam (FLU) and diazepam (DZP) were assessed in mice by observation of digging behavior in an escape task. Reliable effects on escape latencies and number of exploratory head pokes were detected at 2 mg/kg for CDZ and FLU. DZP produced dose-dependent effects at 0.2, 0.4 and 0.6 mg/kg. Ro 15-1788 antagonized the effects of DZP (0.6 mg/kg). Ethanol (0.75 and 1.5 g/kg) produced effects similar to those of the benzodiazepines. The dynamics of this naturalistic behavior avoid the need for direct aversive stimulation or food/water deprivation to set up an approach avoidance or conflict test. Combined with a multivariate (discriminant) analysis, the approach provides a sensitive assessment of anxiolytic drug activity.

Original language	English (US)
Pages (from-to)	265-270
Number of pages	6
Journal	Neuroscience Letters
Volume	63
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(86)90367-8
State	Published - Jan 30 1986
Externally published	Yes

Keywords

benzodiazepine
conflict test
escape digging
ethanol
mouse

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(86)90367-8

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title = "Naturalistic behavioral assessment of anxiolytic properties of benzodiazepines and ethanol in mice",

abstract = "Effects of chlordiazepoxide (CDZ), flurazepam (FLU) and diazepam (DZP) were assessed in mice by observation of digging behavior in an escape task. Reliable effects on escape latencies and number of exploratory head pokes were detected at 2 mg/kg for CDZ and FLU. DZP produced dose-dependent effects at 0.2, 0.4 and 0.6 mg/kg. Ro 15-1788 antagonized the effects of DZP (0.6 mg/kg). Ethanol (0.75 and 1.5 g/kg) produced effects similar to those of the benzodiazepines. The dynamics of this naturalistic behavior avoid the need for direct aversive stimulation or food/water deprivation to set up an approach avoidance or conflict test. Combined with a multivariate (discriminant) analysis, the approach provides a sensitive assessment of anxiolytic drug activity.",

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author = "Dudek, {Bruce C.} and Angela Maio and Phillips, {Tamara J.} and Mark Perrone",

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language = "English (US)",

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journal = "Neuroscience Letters",

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T1 - Naturalistic behavioral assessment of anxiolytic properties of benzodiazepines and ethanol in mice

AU - Dudek, Bruce C.

AU - Maio, Angela

AU - Phillips, Tamara J.

AU - Perrone, Mark

PY - 1986/1/30

Y1 - 1986/1/30

N2 - Effects of chlordiazepoxide (CDZ), flurazepam (FLU) and diazepam (DZP) were assessed in mice by observation of digging behavior in an escape task. Reliable effects on escape latencies and number of exploratory head pokes were detected at 2 mg/kg for CDZ and FLU. DZP produced dose-dependent effects at 0.2, 0.4 and 0.6 mg/kg. Ro 15-1788 antagonized the effects of DZP (0.6 mg/kg). Ethanol (0.75 and 1.5 g/kg) produced effects similar to those of the benzodiazepines. The dynamics of this naturalistic behavior avoid the need for direct aversive stimulation or food/water deprivation to set up an approach avoidance or conflict test. Combined with a multivariate (discriminant) analysis, the approach provides a sensitive assessment of anxiolytic drug activity.

AB - Effects of chlordiazepoxide (CDZ), flurazepam (FLU) and diazepam (DZP) were assessed in mice by observation of digging behavior in an escape task. Reliable effects on escape latencies and number of exploratory head pokes were detected at 2 mg/kg for CDZ and FLU. DZP produced dose-dependent effects at 0.2, 0.4 and 0.6 mg/kg. Ro 15-1788 antagonized the effects of DZP (0.6 mg/kg). Ethanol (0.75 and 1.5 g/kg) produced effects similar to those of the benzodiazepines. The dynamics of this naturalistic behavior avoid the need for direct aversive stimulation or food/water deprivation to set up an approach avoidance or conflict test. Combined with a multivariate (discriminant) analysis, the approach provides a sensitive assessment of anxiolytic drug activity.

KW - benzodiazepine

KW - conflict test

KW - escape digging

KW - ethanol

KW - mouse

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Naturalistic behavioral assessment of anxiolytic properties of benzodiazepines and ethanol in mice

Abstract

Keywords

ASJC Scopus subject areas

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