Naturalistic behavioral assessment of anxiolytic properties of benzodiazepines and ethanol in mice

Bruce C. Dudek, Angela Maio, Tamara J. Phillips, Mark Perrone

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Effects of chlordiazepoxide (CDZ), flurazepam (FLU) and diazepam (DZP) were assessed in mice by observation of digging behavior in an escape task. Reliable effects on escape latencies and number of exploratory head pokes were detected at 2 mg/kg for CDZ and FLU. DZP produced dose-dependent effects at 0.2, 0.4 and 0.6 mg/kg. Ro 15-1788 antagonized the effects of DZP (0.6 mg/kg). Ethanol (0.75 and 1.5 g/kg) produced effects similar to those of the benzodiazepines. The dynamics of this naturalistic behavior avoid the need for direct aversive stimulation or food/water deprivation to set up an approach avoidance or conflict test. Combined with a multivariate (discriminant) analysis, the approach provides a sensitive assessment of anxiolytic drug activity.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalNeuroscience Letters
Volume63
Issue number3
DOIs
StatePublished - Jan 30 1986

Keywords

  • benzodiazepine
  • conflict test
  • escape digging
  • ethanol
  • mouse

ASJC Scopus subject areas

  • Neuroscience(all)

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