Natural history of 'silent' lupus nephritis

W. M. Bennett, E. J. Bardana, Douglas Norman, Donald Houghton

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Twenty patients with systemic lupus erythematosus but without evident renal involvement previously underwent percutaneous renal biopsy. Findings revealed almost universal pathologic evidence of nephritis. Included were three patients who had diffuse proliferative changes and five who had subendothelial electron dense deposits. Only four patients developed clinical renal disease during the follow-up period while no patient died or required dialysis. Using the Life Table Method, the cumulative percentage of patients free from any clinical renal disease was over 60% at 10 yr from the time of diagnosis of systemic lupus, and at 8 yr from the time of the original biopsy. It is concluded that silent lupus nephritis, regardless of histologic subtype, has a favorable prognosis. These data may not be applicable to patients with similar biopsies who have evidence of clinical lupus nephritis.

Original languageEnglish (US)
Pages (from-to)359-363
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume1
Issue number6
StatePublished - 1982

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Lupus Nephritis
Natural History
Kidney
Biopsy
Life Tables
Nephritis
Systemic Lupus Erythematosus
Dialysis
Electrons

ASJC Scopus subject areas

  • Nephrology

Cite this

Natural history of 'silent' lupus nephritis. / Bennett, W. M.; Bardana, E. J.; Norman, Douglas; Houghton, Donald.

In: American Journal of Kidney Diseases, Vol. 1, No. 6, 1982, p. 359-363.

Research output: Contribution to journalArticle

Bennett, W. M. ; Bardana, E. J. ; Norman, Douglas ; Houghton, Donald. / Natural history of 'silent' lupus nephritis. In: American Journal of Kidney Diseases. 1982 ; Vol. 1, No. 6. pp. 359-363.
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