Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration

Age-Related Eye Disease Study 2 Report No. 17

Jeannette J. Yu, Elvira Agrón, Traci E. Clemons, Amitha Domalpally, Freekje van Asten, Tiarnan D. Keenan, Catherine Cukras, Emily Y. Chew, Emily Y. Chew, Frederick L. Ferris, John Paul SanGiovanni, Elvira Agrón, Traci Clemons, Anne Lindblad, Robert Lindblad, Nilay Shah, Robert Sperduto, Wendy McBee, Gary Gensler, Molly Harrington & 982 others Alice Henning, Katrina Jones, Kumar Thotapally, Diana Tull, Valerie Watson, Kayla Williams, Christina Gentry, Francine Kaufman, Chris Morrison, Elizabeth Saverino, Sherrie Schenning, Barbara Blodi, Matthew Davis, Amitha Domalpally, Kathy Glander, Gregory Guilfoil, Larry D. Hubbard, Kristine Johnson, Barbara Nardi, Michael Neider, Nancy Robinson, Eileen Rosensteel, Hugh Wabers, Grace Zhang, Antonio Capone, Bawa Dass, Kimberly Drenser, Bruce R. Garretson, Tarek S. Hassan, Michael Trese, George A. Williams, Jeremy Wolfe, Tina Bell, Mary Zajechowski, Dennis Bezaire, Fran McIver, Anthony Medina, Jackie Pagett, Stephanie Hatch Smith, Lynn Swartz, Tom Treuter, Andrew Antoszyk, Justin Brown, David J. Browning, Walter Holland, Angella Karow, Kelly Stalford, Angela Price, Sarah Ennis, Sherry Fredenberg, Jenna Herby, Uma Balasubramaniam, Loraine Clark, Donna McClain, Michael McOwen, Lynn Watson, Michael Klein, Steven Bailey, Thomas J. Hwang, Andreas (Andy) Lauer, J. Timothy Stout, Patty McCollum, Milt Johnson, Patrick B. Rice, Ivana Kim, John Loewenstein, Joan Miller, Lucia Sobrin, Lucy Young, Jacqueline Sullivan, Patricia Houlihan, Linda Merry, Ann Marie Lane, Ursula Lord Bator, Claudia Evans, Sarah Brett, Charleen Callahan, Marcia Grillo, David Walsh, Kamella Lau Zimmerman, Rajiv Anand, Lori E. Coors, Dwain G. Fuller, Rand Spencer, Robert C. Wang, Karen Duignan, Sally Arceneaux, Hank Aguado, Nicholas Hesse, Michael Mackens, Brian Swan, Wai T. Wong, Catherine Cukras, Monica Dalal, Naima Jacobs-El, Catherine Meyerle, Benjamin Nicholson, Henry Wiley, Katherine Hall Shimel, Angel Garced, Janice Oparah, Greg Short, Alana Temple, Babilonia Ayukawa, Guy Foster, Darryl Hayes, Dessie Koutsandreas, Roula Nashwinter, John Rowan, Michael Bono, Denise Cunningham, Marilois Palmer, Alicia Zetina, David H. Orth, Kourous Rezaei, Joseph Civantos, Sohail Hasan, Kirk Packo, Celeste Figliulo, Pam Stanberry, Tara Farmer, Kiersten Nelson, Shannya Townsend-Patrick, Philip Rosenfeld, Royce Chen, Rishi Doshi, Sander Dubovy, Brian T. Kim, Matthew Lowrance, Andrew Moshfeghi, Zayna Nahas, Gary Schienbaum, John Vishak, Christina Weng, Zohar Yehoshua, Belen Rodriguez, Jose Rebimbas, Jane Gleichauf, Mike Kicak, Jason Mena, Tim Odem, Elizabeth Sferza-Camp, Alicia Disgdiertt, Jim Oramas, Isabel Rams, Stephanie Thatcher, Susan B. Bressler, Neil M. Bressler, Daniel Finkelstein, Steven H. Sherman, Sharon Solomon, Howard S. Ying, Rita Denbow, Deborah Phillips, Elizabeth Radcliffe, Judy Belt, Dennis Cain, David Emmert, Mark Herring, Jacquelyn McDonald, G. Baker Hubbard, Chris S. Bergstrom, Blaine Cribbs, Andrew Hendrick, Brandon Johnson, Philip Laird, Sonia Mehta, Timothy Olsen, Justin Townsend, Jion Yan, Steven Yeh, Linda Curtis, Judy Brower, Hannah Yi, Jannah Rutter Dobbs, Debbie Jordan, Michael J. Elman, Robert A. Liss, Jo Ann Starr, Jennifer Belz, Charlene Putzulo, Teresa Coffey, Ashley Davis, Pamela Singletary, Giorya Shabi Andreani, Theresa Cain, Daniel Ketner, Peter Sotirakos, Suresh Chandra, Barbara A. Blodi, Michael M. Altaweel, Ronald P. Danis, Justin L. Gottlieb, Michael Ip, Ronald Klein, T. Michael Nork, Thomas S. Stevens, Kathryn Burke, Shelly Olson, Kristine Dietzman, Barbara Soderling, Guy Somers, Angie Wealti, Denise Krolnik, John Peterson, Sandra Reed, Thomas Friberg, Andrew Eller, Denise Gallagher, Leanne Labriola, Melissa Pokrifka, Aron Gedansky, Natalie Anthony, Cassandra Grzybowski, Dawn Matthews, Sharon Murajda-Jumba, Jessica Toro, David G. Callanan, Wayne A. Solley, Patrick Williams, Sandy Lash, Bob Boleman, Chris Dock, Gary Edd Fish, Michel Shami, Brenda Arrington, Ashaki Meeks, Alan R. Margherio, Paul Raphaelian, Debra Markus, Justin Langdon, Elizabeth Truax, Sandy Lewis, Brad Terry, Alan J. Ruby, Amy Noffke, Kean Oh, Ramin Sarrafizadeh, Scott Sneed, Julie Hammersley, Serena Neal, Mary Doran, Nan Jones, Lisa Preston, Heather Jessick, Tanya Tracy Marsh, Michael Tolentino, Adam Berger, Richard Hamilton, David Misch, Suk Jin Moon, Dawn Sutherland, Vera Dilts, Sara Henderson, Esmeralda Medina, Donald Trueman, Laura Holm, Jason Strickland, Darmakusuma Ie, Jeffrey L. Lipkowitz, Kekul B. 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Research output: Contribution to journalArticle

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Abstract

Purpose: To investigate the natural history and genetic associations of drusenoid pigment epithelial detachment (DPED) associated with age-related macular degeneration (AMD). Design: Retrospective analysis of a prospective cohort study. Participants: Of the 4203 Age-Related Eye Disease Study 2 (AREDS2) participants, 391 eyes (325 participants) had DPED without late AMD at the time of DPED detection. Genetic analyses included 120 white AREDS2 participants and 145 Age-Related Eye Disease Study (AREDS) participants with DPED. Methods: Baseline and annual stereoscopic fundus photographs were graded centrally to detect DPED, a well-defined yellow elevated mound of confluent drusen ≥433 μm in diameter, and to evaluate progression rates to late AMD: geographic atrophy (GA) and neovascular (NV)-AMD. Five single nucleotide polymorphisms (CFH [rs10611670], C3 [rs2230199], CFI [rs10033900], C2/CFB [rs114254831], ARMS2 [rs10490924]) and genetic risk score (GRS) group were investigated for association with DPED development. Kaplan–Meier analyses and multivariable proportional hazard regressions were performed. Main Outcome Measures: Progression rates to late AMD and decrease of ≥3 lines in visual acuity (VA) from the time of DPED detection; association of rate of DPED development with genotype. Results: Mean (standard deviation [SD]) follow-up time from DPED detection was 4.7 (0.9) years. DPED was associated with increased risk of progression to late AMD (hazard ratio [HR], 2.36; 95% confidence interval [CI], 1.98–2.82; P < 0.001); 67% of eyes progressed to late AMD 5 years after DPED detection. Drusenoid pigment epithelial detachment was associated with increased risk of ≥3 lines of VA loss (HR, 3.08; CI, 2.41–3.93; P < 0.001) with 46% of eyes experiencing vision loss at 5 years (with or without progression to late AMD). ARMS2 risk alleles (1 vs. 0: HR, 2.72, CI, 1.58–4.70; 2 vs. 0: HR, 3.16, CI, 1.60–6.21, P < 0.001) and increasing GRS group (4 vs. 1) (HR, 12.17, CI, 3.66–40.45, P < 0.001) were significantly associated with DPED development in AREDS. There were no significant genetic results in AREDS2. Conclusions: This study replicates the results of previous natural history studies of eyes with DPED including the high rates of progression to late AMD and vision loss (regardless of progression to late AMD). The genetic associations are consistent with genes associated with AMD progression.

Original languageEnglish (US)
JournalOphthalmology
DOIs
StateAccepted/In press - Jan 1 2018

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Eye Diseases
Macular Degeneration
Natural History
Confidence Intervals
Visual Acuity
Geographic Atrophy
Single Nucleotide Polymorphism
Cohort Studies
Alleles
Genotype
Outcome Assessment (Health Care)
Prospective Studies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration : Age-Related Eye Disease Study 2 Report No. 17. / Yu, Jeannette J.; Agrón, Elvira; Clemons, Traci E.; Domalpally, Amitha; van Asten, Freekje; Keenan, Tiarnan D.; Cukras, Catherine; Chew, Emily Y.; Chew, Emily Y.; Ferris, Frederick L.; SanGiovanni, John Paul; Agrón, Elvira; Clemons, Traci; Lindblad, Anne; Lindblad, Robert; Shah, Nilay; Sperduto, Robert; McBee, Wendy; Gensler, Gary; Harrington, Molly; Henning, Alice; Jones, Katrina; Thotapally, Kumar; Tull, Diana; Watson, Valerie; Williams, Kayla; Gentry, Christina; Kaufman, Francine; Morrison, Chris; Saverino, Elizabeth; Schenning, Sherrie; Blodi, Barbara; Davis, Matthew; Domalpally, Amitha; Glander, Kathy; Guilfoil, Gregory; Hubbard, Larry D.; Johnson, Kristine; Nardi, Barbara; Neider, Michael; Robinson, Nancy; Rosensteel, Eileen; Wabers, Hugh; Zhang, Grace; Capone, Antonio; Dass, Bawa; Drenser, Kimberly; Garretson, Bruce R.; Hassan, Tarek S.; Trese, Michael; Williams, George A.; Wolfe, Jeremy; Bell, Tina; Zajechowski, Mary; Bezaire, Dennis; McIver, Fran; Medina, Anthony; Pagett, Jackie; Smith, Stephanie Hatch; Swartz, Lynn; Treuter, Tom; Antoszyk, Andrew; Brown, Justin; Browning, David J.; Holland, Walter; Karow, Angella; Stalford, Kelly; Price, Angela; Ennis, Sarah; Fredenberg, Sherry; Herby, Jenna; Balasubramaniam, Uma; Clark, Loraine; McClain, Donna; McOwen, Michael; Watson, Lynn; Klein, Michael; Bailey, Steven; Hwang, Thomas J.; Lauer, Andreas (Andy); Stout, J. Timothy; McCollum, Patty; Johnson, Milt; Rice, Patrick B.; Kim, Ivana; Loewenstein, John; Miller, Joan; Sobrin, Lucia; Young, Lucy; Sullivan, Jacqueline; Houlihan, Patricia; Merry, Linda; Lane, Ann Marie; Bator, Ursula Lord; Evans, Claudia; Brett, Sarah; Callahan, Charleen; Grillo, Marcia; Walsh, David; Zimmerman, Kamella Lau; Anand, Rajiv; Coors, Lori E.; Fuller, Dwain G.; Spencer, Rand; Wang, Robert C.; Duignan, Karen; Arceneaux, Sally; Aguado, Hank; Hesse, Nicholas; Mackens, Michael; Swan, Brian; Wong, Wai T.; Cukras, Catherine; Dalal, Monica; Jacobs-El, Naima; Meyerle, Catherine; Nicholson, Benjamin; Wiley, Henry; Shimel, Katherine Hall; Garced, Angel; Oparah, Janice; Short, Greg; Temple, Alana; Ayukawa, Babilonia; Foster, Guy; Hayes, Darryl; Koutsandreas, Dessie; Nashwinter, Roula; Rowan, John; Bono, Michael; Cunningham, Denise; Palmer, Marilois; Zetina, Alicia; Orth, David H.; Rezaei, Kourous; Civantos, Joseph; Hasan, Sohail; Packo, Kirk; Figliulo, Celeste; Stanberry, Pam; Farmer, Tara; Nelson, Kiersten; Townsend-Patrick, Shannya; Rosenfeld, Philip; Chen, Royce; Doshi, Rishi; Dubovy, Sander; Kim, Brian T.; Lowrance, Matthew; Moshfeghi, Andrew; Nahas, Zayna; Schienbaum, Gary; Vishak, John; Weng, Christina; Yehoshua, Zohar; Rodriguez, Belen; Rebimbas, Jose; Gleichauf, Jane; Kicak, Mike; Mena, Jason; Odem, Tim; Sferza-Camp, Elizabeth; Disgdiertt, Alicia; Oramas, Jim; Rams, Isabel; Thatcher, Stephanie; Bressler, Susan B.; Bressler, Neil M.; Finkelstein, Daniel; Sherman, Steven H.; Solomon, Sharon; Ying, Howard S.; Denbow, Rita; Phillips, Deborah; Radcliffe, Elizabeth; Belt, Judy; Cain, Dennis; Emmert, David; Herring, Mark; McDonald, Jacquelyn; Hubbard, G. Baker; Bergstrom, Chris S.; Cribbs, Blaine; Hendrick, Andrew; Johnson, Brandon; Laird, Philip; Mehta, Sonia; Olsen, Timothy; Townsend, Justin; Yan, Jion; Yeh, Steven; Curtis, Linda; Brower, Judy; Yi, Hannah; Dobbs, Jannah Rutter; Jordan, Debbie; Elman, Michael J.; Liss, Robert A.; Starr, Jo Ann; Belz, Jennifer; Putzulo, Charlene; Coffey, Teresa; Davis, Ashley; Singletary, Pamela; Andreani, Giorya Shabi; Cain, Theresa; Ketner, Daniel; Sotirakos, Peter; Chandra, Suresh; Blodi, Barbara A.; Altaweel, Michael M.; Danis, Ronald P.; Gottlieb, Justin L.; Ip, Michael; Klein, Ronald; Nork, T. Michael; Stevens, Thomas S.; Burke, Kathryn; Olson, Shelly; Dietzman, Kristine; Soderling, Barbara; Somers, Guy; Wealti, Angie; Krolnik, Denise; Peterson, John; Reed, Sandra; Friberg, Thomas; Eller, Andrew; Gallagher, Denise; Labriola, Leanne; Pokrifka, Melissa; Gedansky, Aron; Anthony, Natalie; Grzybowski, Cassandra; Matthews, Dawn; Murajda-Jumba, Sharon; Toro, Jessica; Callanan, David G.; Solley, Wayne A.; Williams, Patrick; Lash, Sandy; Boleman, Bob; Dock, Chris; Fish, Gary Edd; Shami, Michel; Arrington, Brenda; Meeks, Ashaki; Margherio, Alan R.; Raphaelian, Paul; Markus, Debra; Langdon, Justin; Truax, Elizabeth; Lewis, Sandy; Terry, Brad; Ruby, Alan J.; Noffke, Amy; Oh, Kean; Sarrafizadeh, Ramin; Sneed, Scott; Hammersley, Julie; Neal, Serena; Doran, Mary; Jones, Nan; Preston, Lisa; Jessick, Heather; Marsh, Tanya Tracy; Tolentino, Michael; Berger, Adam; Hamilton, Richard; Misch, David; Moon, Suk Jin; Sutherland, Dawn; Dilts, Vera; Henderson, Sara; Medina, Esmeralda; Trueman, Donald; Holm, Laura; Strickland, Jason; Ie, Darmakusuma; Lipkowitz, Jeffrey L.; Shah, Kekul B.; Geraghty, Susan; Sannazzaro, Beverly; Harper, Morgan; Bayer, Krista; Lansing, Mary B.; Fox, Lauren B.; Lee, Rebecca; Stallman, Jay B.; Jacobson, Michael; Koh, Sean; Lampert, Scott; Miller, John; Rivellese, Mark; Sharma, Atul; Stoltz, Robert A.; Vanderveldt, Stephanie; Marcus, Leslie; Hendricks, Starr; Hollman, Ryan; Betanzos, Grethel; Ellorin, Leslie; Fulbright, Shelly; McCormick, Debbie; Edwards, Paul A.; Hall, Julianne; Monk, Mary; Gutkowski, Melanie; Mazurek, Melina; Murphy, Janet; Gusas, Katherine; Moffett, Crystal; Burley, David; Chesney, Nicole; Kilgo, Katie; Rusinek, Brian; Stern, Bradley; Troszak, Tracy; Baker-Levingston, Rhonda; Baker, Carl W.; Caldwell, Tracey; Walker, Tammy; Lambert, Lynnette F.; Martin, Tracey; Palmer, Mary Jill; Williams, Tana; Novak, Michael A.; Coney, Joseph; Miller, David G.; Pendergast, Scott; Singerman, Lawrence; Zakov, Nicholas; Zegarra, Hernando; DuBois, Kim; Rath, Susan; Revella, Lori; Brink, Tammy; Drury, Kim; Hogue, Lisa; Ilc, Mary; Keller, Connie; McNamara, Elizabeth; Tanner, Vivian; Cunningham, Tamara; DuBois, John; Greanoff, Gregg; Nitzsche, Trina; Smith-Brewer, Sheila; Isernhagen, Ricky D.; Kitchens, John W.; Stone, Thomas W.; Wood, William J.; Holcomb, Diana; Therrien, Virginia; Buck, Michelle; Van Arsdall, Jeanne; Slade, Edward; Schneiderman, Todd E.; Spinak, David J.; Gaedke, Jackie; Brown, Heather Davis; Helgren, Dan; Pangelinan, Jenifer Garrison; Halperin, Lawrence; Anagnoste, Scott; Dhalla, Mandeep; Rosenberg, Krista; Taney, Barry; Thompson, W. Scott; Lopez, Jaclyn; Hamlin, Monica; Lopez, Monica; Mariano, Jamie; Quinchia, Evelyn; Aramayo, Patricia; Veksler, Rita; Lee, Michael; Dreyer, Richard; Handelman, Irvin; Ma, Colin; Peters, Mark; Hobbs, Stephen; Milliron, Amanda; Kopfer, Marcia; Connaughton, Michele; Hoerner, A. Christine; Logan, R. Joseph; Wohlsein, Harry J.; Boyer, David; Chu, Thomas G.; Dayani, Pouya; Liao, David; Novack, Roger L.; Rahhal, Firas M.; Roe, Richard; Tabandeh, Homayoun; Bayramyan, Janet; Gasparyan, Tammy; Hoang, Connie; Kurokouchi, Janet; Lo, Tammy Eileen; Ngo, Richard; Nguyen, Mary Ann; Peyton, Michael; Yoon, Charles; Sierra, Julio; Zamboni, Adam; Kessinger, Jeff; Protacio, Eric; Smucker, Adam; Rath, Pamela; Bergren, Robert; Doft, Bernard; Liu, Judy; Olsen, Karl; Merlotti, Lori; Ingram, Willia; Marfisi, Kellianne; Yeckel, Kimberly; Carmelo, Heather Schultz; Fec, Amanda; McBroom, Keith; Steinberg, David; Levy, Marc; Abrams, Jody; Chen, Melvin; Torres, Waldemar; Jelemensky, Peggy; Prybylski, Mark; Raphael, Tara; Appleby, Diana; Rodman, Charlotte; Sneath, Mark; Rosa, Robert H.; Hoelscher, Vanessa; Castano, Adelia; Parker, Jocelyn; Hoskins, John; Anderson, Nicholas; Googe, Joseph; McMillan, Tod A.; Miller, James; Perkins, Stephen; Oliver, Kristina; Beerbower, Jennifer; Gilliland, Bruce; Hunt, Cecile; Jacobus, Mike; Lince, Raul; Morris, Christopher; Oelrich, Sarah; Whetstone, Jerry; Chan, Clement K.; Lin, Steven; Walther, Kim; Gonzales, Tiana; Myers, Lenise; Huff, Kenneth; Brown, David M.; Chen, Eric; Benz, Matthew S.; Fish, Richard H.; Kim, Rosa Y.; Major, James; Wong, Tien Pei; Wycoff, Charles; Cone, Cassandra; Gilaspia, Debbie Goates; Landaverde, Nubia; Smith, Robert; Zamora, Deneva; Sneed, Veronica; Vela, Melina; Kegley, Eric; Greven, Craig; Kurup, Shree; Richards, Charles; Slusher, Madison; Everhart, Cara; Fish, Joan; Miller, David; Tyler, Marshall; Lujan, Brandon; Fu, Arthur D.; Johnson, Robert N.; Lujan, Brandon; McDonald, H. Richard; Rodriguez, Rosa; Ansari, Nina; Joaquin, Jeanifer; Linares, Silvia; Lopez, Lizette; Sabio, Jessica; Grout, Sean; Indermill, Chad; Urias, Yesmin; Zimmerman, Roberto; Margulies, Linda; Schmidt, Sara J.; Meier, Joy L.; Hadley, Sherry L.; Rosenthal, William; Johnson, Barbara; Swafford, Lois; Shields, Richard; Varner, R. Scott; Rosen, Richard; Gentile, Ronald; Rivas, Melissa; Tai, Katy W.; Carrasquillo-Boyd, Wanda; Masini, Robert; Stoller, Glenn; Carnevale, Ken; LaRosa, Diane M.; Burger, Barbara; Conway, Tereza; Del Castillo, Carla; Diaz, Julissa; Jones, Susan; Mondoc, Nina; Balfour, Charlene; Vitha, C. H.; Lutz, Jennifer; McGinley, Barbara; El Baba, Fadi; Lavorna, Ann Marie; Jones, Renee; Lewis, Jean; Tenzler, Ruth; Salvas-Mladek, Mary; Van Kesteren, Diane; McLean, W. Copley; Bridges, W. Zachery; Stone, Cameron; Ammons, Denise; Lamy, Mary; Menzel, Andrea; Raymer, Lea Doll; Campbell, Barbara; Hawkins, Lisa; Rickman, Leslie; Sherlin, Lorraine; Price, Paula; Sinyai, Albert; Kingsley, Ronald; Bradford, Reagan H.; Leonard, Robert E.; Icks, Sonny; Bergman, Vanessa; Ross, Brittany; Burris, Russ; Butt, Amanda; Richmond, Rob; Lyon, Alice; Gill, Manjot; Jampol, Lee; Mizra, Rukhsana; Rozenbajgier, Zuzanna; Chapman, Jeremy; Kaminski, Lori; Degillio, Andrea; Simjanoski, Evica; Heier, Jeffrey; Cho, Hyung; Cleary, Tina Scheufele; Goldman, Darin; Shah, Chirag; Topping, Trexler; Weber, Marissa; Wiegand, Torsten; Schindelheim, Jeremy; Bankert, Joy; Stone, Jennifer; Nowak, Alison; Chong, Sandy; Williams, Lindsay; Bennett, Steven; Donovan, Dennis; Graham, Margaret; Jones, Cullen; Fung, Anne; Bayabo, Jan Kristine; Bosch, Razelda; Cruz, Esperanza; Emerson, Ashley; Fleming, Alycia; Barsness, Denice; Rodriguez, Jorge; Soboleva, Marina; Scott, Ingrid U.; Bowie, Esther; Neely, Kimberly A.; Quillen, David A.; Walter, Laura; Bennett, Timothy; Strong, James; Wells, John; Clark, Lloyd; Miller, Peggy; Taylor, Mallie; Swinford, Tiffany; Spivey, Robbin; Banach, Michael; Ho, Lawrence; Lanning, Richard; Pheasant, Thomas R.; Prensky, Jay G.; Truong, Steven; Teatsworth, Julia; Dietrich, Michelle; Wasilus, Ann; Miller, Ann; Rakes, Megan; Slagle, Teresa; Richards, Michelle; Schuessler, Patricia; Stover, Lacy; Beer, Paul; Falk, Naomi S.; Shannon, Mary Beth; Olmeda, Jeannie; Berdeen, Don; Fisher, Joseph F.; Folk, James; Russell, Stephen; Taylor, Barbara; Hinz, Connie; Walshire, Jean; Stockman, Heather; Critser, Bruce; Karakas, Stefani; Montague, Cindy; Verdick, Randy; Gupta, Omesh; Maguire, Joseph; Brady, Christopher; DeCroos, Francis Char; Dollin, Michael; Garg, Sunir; Gerstenblith, Adam; Haller, Julia; Ho, Allen C.; Hsu, Jason; Kaiser, Richard; Pitcher, John; Regillo, Carl; Shah, Rajiv; Spirn, Marc; Tasman, William; Vander, James; Senderowitsch, Noga; Formoso, Michele; Markun, Michelle; George, Cedric; Centinaro, Christina; Grande, Lisa; Carey, Stefanie; Liebenbaum, Elaine; Sadda, Srini Vas; Humayun, Mark; Sierra, Rachel; Corona, Elizabeth; Padilla, Margaret; Nu, Moonseok; Ramos, Sylvia; Barnett, Cullen; Currie, Glenn; Gottlieb, Cornelia; Garfinkel, Richard; Berinstein, Daniel; Colyer, Marcus; Deegan, William; Min-Shyue Lai, Michael; Murphy, Robert; Osman, Michael; Rivers, Michael; Sanders, Reginald; von Fricken, Manfred A.; Oliver, Debbie; Kirshon, Jeanne; Snowden, Tanya Alexander; Blondo, Thomas; Cronise, Alysia; Denny, Vanessa; Mendez, Kylie; Newgen, Janine; Davis, Justin; Flory, Mike; Frantz, Robert; Murphy, Bryan; Rauch, Steve; Kim, Judy E.; Bachman, Jane; Connor, Thomas B.; Han, Dennis P.; Stepian, Kimberly; Weinberg, David V.; Wirostko, William J.; Packard, Krissa; Kaczanowski, Tracy; Williams, Vesper; Barwick, Vicki; Flanders, Judy; Backes, Dennis; Beringer, Joe; Keller, Kristy; Selchert, Kathy; Bernstein, Paul; Teske, Michael; Vitale, Albert; Allman, Susan; Carlstrom, Bonnie; Wegner, Kimberley; Haroldsen, Anne; Harrison, Deborah; Fry, Cyrie; Gilman, James; Jenkins, Glen; Morris, Paula; Rauser, Michael; Fan, Joseph; Suthar, Mukesh; Santiago, Gisela; Halsey, Kara Rollins; Quesada, Christy; Kiernan, William; Knabb, Jesse; Lewis, Richard Alan; Dorenbach, Cindy; Spencer, Steven; Barnett, Dana; Morales, Joseph; Fishburne, Barron C.; Gross, Jeffrey G.; Magee, Michael A.; Flowers, Amy; McDowell, Angie; Price, Randall; Huang, Suber; Tang, Johnny; Wilker, Shawn; Hornsby, Cherie; Ferguson, Lisa; Krogstad, Kirk; Adamovsky, Riva; Allchin, Peggy; Carlton, Kathleen; Clow, Claudia; Sholtis, Kelly; Burke, Stephanie; Harrod, Mark; Hrvatin, Stacie; Pankhurst, Geoffrey; Sabates, Nelson R.; Cassell, Michael; Desai, Komal; Poulose, Abraham; Sabates, Felix; Chen, Yin; Gallimore, Gary; Konior, Yolanda; Kim, Nicola; Uwaydat, Sami; Troillett, Deborah; Aletter, Karen; Frank, Robert N.; Abrams, Gary; Puklin, James; Tewari, Asheesh; Milanovic, Cheryl; Bailey, Melanie; Griffith, David; McDonald, Dena; Morehead, Kit; Sadikovic, Zlatan; Schillace, Lisa; Silvis, Elizabeth; Joondeph, Brian; Christmas, Nancy; Johnson, David; Kimura, Alan; Liu, Mimi; Petty, Stephen; Zilis, John; Benitez, Jenny; Catlett, Cassandra Berryman; Fluegel, Eric; Mowry, Shane; Nguyen, Hoang; Reflow, David; Houghton, Odette M.; Garg, Seema; Landers, Maurice B.; Meredith, Travis; Barnhart, Sandy; Karmalkar, Megha; Cantrell, Debra; Esquejo-Leon, Rona Lyn; Manor, Linda; Pope, Sue; Stines, David; Stokely, Amelia; Hainsworth, Dean; Helming, Dyann; Eichelberger, Debbie; Leaton, Mary Paige; Hamm, Chuck; Chaum, Edward; Iannaccone, Alessandro; Jennings, Barbara; Murray, Tracy; Mastellone, Joe; Millay, Robert; Kim, Brian; Goddard, Theresa; Beaudette, Liza Jarrett; Changelian-Aitken, Nina; Corrada, Fernando; Dubuque, Jason; Iezzi, Raymond; Bakri, Sophie J.; Pulido, Jose S.; Vogen, Diane; Nielsen, Rebecca; Berg, Karin; Burrington, Jean; Howard, Shannon; Overend, Joan; Krason, Zbigniew; Lewison, Denise; Link, Thomas; Blinder, Kevin J.; Engelbrecht, Nicholas E.; Grand, M. Gilbert; Joseph, Daniel P.; Shah, Gaurav K.; Smith, Bradley; Thomas, Matthew; Weeks, Rhonda; Boyd, Lynda; Gabel, Dana; Adelman, Ron; Huang, John; Kempton, James; Parnes, Aaron; Dupont, Jennifer; Perotti, Elizabeth; Donaldson, Victoria; Fong, Kenneth; Ossorio, Pamela; Agarwal, Anita; Sternberg, Paul; Owings, Sandy; Adkins, Tony; Lok, Elaine; Munn, Garvin; Skellie, Buddy; Bhagat, Neelakshi; Roy, Monique S.; Zarbin, Marco; Fay, Catherine; Lazar, Michael; Malpica, Beth; Mikheyav, Tatiana; Ulanski, Lawrence; Lim, Jennifer; Niec, Marcia; Johnson, Tametha; Ovando, Yesenia; Carroll, Catherine Nail; Janowicz, Mark; Schwartz, Steven; Cupp, David; Gorin, Michael; Heilweil, Gad; Hosseini, Hamid; Hubschman, Jean Pierre; Kreiger, Allan; McCannel, Tara Young; Pan, Carolyn; Sarraf, David; Tsui, Irena; Udoetek, Joshua; Voleti, Vinad; Hitchcock, Logan; Ostrick, Rosaleen; Chun, Melissa; Kageyama, Jennie; Davila, Nilo; Lipka, Kristin; Shin, Christina; Owsley, Cynthia; Albert, Michael; Feist, Richard; Mason, John; Thomley, Martin; Johnson, Angelia; Clark, Mark; Emond, Tracy; Hamela, Joanna; Marsh, Angela; Searcey, Karen; Rookard, Kia; He, Yu Guang; Ufret-Vincenty, Rafael L.; Molai, Mike; Anderson, William; Horna, John; Letson, Alan; Cebulla, Colleen; Chang, Susie; Davidorf, Fred; Salerno, Jill; Sladoje, Laura; Stetson, Christina; Perry, Jeri; Savage, Scott; Toth, Cynthia; Jaffe, Glenn; Schuman, Stefanie; Sarin, Neeru; Crowell, Jim; Keaton, Tiffanie; Kelly, Michael; Lutman, Brian; Skelly, Marriner; Welch, Lauren; Morse, Lawrence; Hunter, Allan; Soon-Chun Park, Susanna; Wallace, Cynthia; Dhillon, Ember; Salvador, Marisa; Holderreed, Barbara; Chandra, Karishma; Kaur, Sashi; Redenbo, Ellen; Hom, Smiley; Cooney, Michael; Barbazetto, Irene; Klancnik, James M.; Sorenson, John A.; Yannuzzi, Lawrence; Scolaro, Maria; Agresta, Eugene; Gonzalez, Nancy; Grover, Sandeep; Chalam, K. V.; Gupta, Shailesh; Lyons, Christopher; Li, Wenhua; Patel, Chirag; Carrion, Jose; Ferreyra, Henry; Rodriguez, Amberly; Molina, Iliana; Balea, Gabriel; Emory, Pam; Rico, Marlene; Siqueiros, Giorgio; Brucker, Alexander J.; Dunaief, Joshua; Grunwald, Juan; Kim, Benjamin; Maguire, Albert M.; VanderBeek, Brian; Drossner, Sheri; DuPont, Joan; Salvo, Rebecca; Berger, Jim; Devine, Cheryl; Nyberg, Bill; Weeney, Laurel; DiLoreto, David; Chung, Mina; Davis, Valerie; MacDowell, Peter; Gara, George O.; Castillo, Daniel; Czubinski, Andrea; Keim, Melissa; Hardy, Brandi; Hollar, Rachel Grunhaus; Schueckler, Lynn; Lyon, Alice T.; Weinberg, Aaron; Shiloach, Mira; Pelkofer, Nicole; Zhou, Qin; McPoland, Laura; Apte, Rajendra; Rao, P. Kumar; Pistorius, Sam; Kambarian, Jamie; Adcock, Eve; Gould, Sarah; Quinn, Melanie; Curtis, Rhonda; Frost, Amy; Meyer, Charla; Rathert, Greg.

In: Ophthalmology, 01.01.2018.

Research output: Contribution to journalArticle

Yu, JJ, Agrón, E, Clemons, TE, Domalpally, A, van Asten, F, Keenan, TD, Cukras, C, Chew, EY, Chew, EY, Ferris, FL, SanGiovanni, JP, Agrón, E, Clemons, T, Lindblad, A, Lindblad, R, Shah, N, Sperduto, R, McBee, W, Gensler, G, Harrington, M, Henning, A, Jones, K, Thotapally, K, Tull, D, Watson, V, Williams, K, Gentry, C, Kaufman, F, Morrison, C, Saverino, E, Schenning, S, Blodi, B, Davis, M, Domalpally, A, Glander, K, Guilfoil, G, Hubbard, LD, Johnson, K, Nardi, B, Neider, M, Robinson, N, Rosensteel, E, Wabers, H, Zhang, G, Capone, A, Dass, B, Drenser, K, Garretson, BR, Hassan, TS, Trese, M, Williams, GA, Wolfe, J, Bell, T, Zajechowski, M, Bezaire, D, McIver, F, Medina, A, Pagett, J, Smith, SH, Swartz, L, Treuter, T, Antoszyk, A, Brown, J, Browning, DJ, Holland, W, Karow, A, Stalford, K, Price, A, Ennis, S, Fredenberg, S, Herby, J, Balasubramaniam, U, Clark, L, McClain, D, McOwen, M, Watson, L, Klein, M, Bailey, S, Hwang, TJ, Lauer, AA, Stout, JT, McCollum, P, Johnson, M, Rice, PB, Kim, 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Yu, Jeannette J. ; Agrón, Elvira ; Clemons, Traci E. ; Domalpally, Amitha ; van Asten, Freekje ; Keenan, Tiarnan D. ; Cukras, Catherine ; Chew, Emily Y. ; Chew, Emily Y. ; Ferris, Frederick L. ; SanGiovanni, John Paul ; Agrón, Elvira ; Clemons, Traci ; Lindblad, Anne ; Lindblad, Robert ; Shah, Nilay ; Sperduto, Robert ; McBee, Wendy ; Gensler, Gary ; Harrington, Molly ; Henning, Alice ; Jones, Katrina ; Thotapally, Kumar ; Tull, Diana ; Watson, Valerie ; Williams, Kayla ; Gentry, Christina ; Kaufman, Francine ; Morrison, Chris ; Saverino, Elizabeth ; Schenning, Sherrie ; Blodi, Barbara ; Davis, Matthew ; Domalpally, Amitha ; Glander, Kathy ; Guilfoil, Gregory ; Hubbard, Larry D. ; Johnson, Kristine ; Nardi, Barbara ; Neider, Michael ; Robinson, Nancy ; Rosensteel, Eileen ; Wabers, Hugh ; Zhang, Grace ; Capone, Antonio ; Dass, Bawa ; Drenser, Kimberly ; Garretson, Bruce R. ; Hassan, Tarek S. ; Trese, Michael ; Williams, George A. ; Wolfe, Jeremy ; Bell, Tina ; Zajechowski, Mary ; Bezaire, Dennis ; McIver, Fran ; Medina, Anthony ; Pagett, Jackie ; Smith, Stephanie Hatch ; Swartz, Lynn ; Treuter, Tom ; Antoszyk, Andrew ; Brown, Justin ; Browning, David J. ; Holland, Walter ; Karow, Angella ; Stalford, Kelly ; Price, Angela ; Ennis, Sarah ; Fredenberg, Sherry ; Herby, Jenna ; Balasubramaniam, Uma ; Clark, Loraine ; McClain, Donna ; McOwen, Michael ; Watson, Lynn ; Klein, Michael ; Bailey, Steven ; Hwang, Thomas J. ; Lauer, Andreas (Andy) ; Stout, J. Timothy ; McCollum, Patty ; Johnson, Milt ; Rice, Patrick B. ; Kim, Ivana ; Loewenstein, John ; Miller, Joan ; Sobrin, Lucia ; Young, Lucy ; Sullivan, Jacqueline ; Houlihan, Patricia ; Merry, Linda ; Lane, Ann Marie ; Bator, Ursula Lord ; Evans, Claudia ; Brett, Sarah ; Callahan, Charleen ; Grillo, Marcia ; Walsh, David ; Zimmerman, Kamella Lau ; Anand, Rajiv ; Coors, Lori E. ; Fuller, Dwain G. ; Spencer, Rand ; Wang, Robert C. ; Duignan, Karen ; Arceneaux, Sally ; Aguado, Hank ; Hesse, Nicholas ; Mackens, Michael ; Swan, Brian ; Wong, Wai T. ; Cukras, Catherine ; Dalal, Monica ; Jacobs-El, Naima ; Meyerle, Catherine ; Nicholson, Benjamin ; Wiley, Henry ; Shimel, Katherine Hall ; Garced, Angel ; Oparah, Janice ; Short, Greg ; Temple, Alana ; Ayukawa, Babilonia ; Foster, Guy ; Hayes, Darryl ; Koutsandreas, Dessie ; Nashwinter, Roula ; Rowan, John ; Bono, Michael ; Cunningham, Denise ; Palmer, Marilois ; Zetina, Alicia ; Orth, David H. ; Rezaei, Kourous ; Civantos, Joseph ; Hasan, Sohail ; Packo, Kirk ; Figliulo, Celeste ; Stanberry, Pam ; Farmer, Tara ; Nelson, Kiersten ; Townsend-Patrick, Shannya ; Rosenfeld, Philip ; Chen, Royce ; Doshi, Rishi ; Dubovy, Sander ; Kim, Brian T. ; Lowrance, Matthew ; Moshfeghi, Andrew ; Nahas, Zayna ; Schienbaum, Gary ; Vishak, John ; Weng, Christina ; Yehoshua, Zohar ; Rodriguez, Belen ; Rebimbas, Jose ; Gleichauf, Jane ; Kicak, Mike ; Mena, Jason ; Odem, Tim ; Sferza-Camp, Elizabeth ; Disgdiertt, Alicia ; Oramas, Jim ; Rams, Isabel ; Thatcher, Stephanie ; Bressler, Susan B. ; Bressler, Neil M. ; Finkelstein, Daniel ; Sherman, Steven H. ; Solomon, Sharon ; Ying, Howard S. ; Denbow, Rita ; Phillips, Deborah ; Radcliffe, Elizabeth ; Belt, Judy ; Cain, Dennis ; Emmert, David ; Herring, Mark ; McDonald, Jacquelyn ; Hubbard, G. Baker ; Bergstrom, Chris S. ; Cribbs, Blaine ; Hendrick, Andrew ; Johnson, Brandon ; Laird, Philip ; Mehta, Sonia ; Olsen, Timothy ; Townsend, Justin ; Yan, Jion ; Yeh, Steven ; Curtis, Linda ; Brower, Judy ; Yi, Hannah ; Dobbs, Jannah Rutter ; Jordan, Debbie ; Elman, Michael J. ; Liss, Robert A. ; Starr, Jo Ann ; Belz, Jennifer ; Putzulo, Charlene ; Coffey, Teresa ; Davis, Ashley ; Singletary, Pamela ; Andreani, Giorya Shabi ; Cain, Theresa ; Ketner, Daniel ; Sotirakos, Peter ; Chandra, Suresh ; Blodi, Barbara A. ; Altaweel, Michael M. ; Danis, Ronald P. ; Gottlieb, Justin L. ; Ip, Michael ; Klein, Ronald ; Nork, T. Michael ; Stevens, Thomas S. ; Burke, Kathryn ; Olson, Shelly ; Dietzman, Kristine ; Soderling, Barbara ; Somers, Guy ; Wealti, Angie ; Krolnik, Denise ; Peterson, John ; Reed, Sandra ; Friberg, Thomas ; Eller, Andrew ; Gallagher, Denise ; Labriola, Leanne ; Pokrifka, Melissa ; Gedansky, Aron ; Anthony, Natalie ; Grzybowski, Cassandra ; Matthews, Dawn ; Murajda-Jumba, Sharon ; Toro, Jessica ; Callanan, David G. ; Solley, Wayne A. ; Williams, Patrick ; Lash, Sandy ; Boleman, Bob ; Dock, Chris ; Fish, Gary Edd ; Shami, Michel ; Arrington, Brenda ; Meeks, Ashaki ; Margherio, Alan R. ; Raphaelian, Paul ; Markus, Debra ; Langdon, Justin ; Truax, Elizabeth ; Lewis, Sandy ; Terry, Brad ; Ruby, Alan J. ; Noffke, Amy ; Oh, Kean ; Sarrafizadeh, Ramin ; Sneed, Scott ; Hammersley, Julie ; Neal, Serena ; Doran, Mary ; Jones, Nan ; Preston, Lisa ; Jessick, Heather ; Marsh, Tanya Tracy ; Tolentino, Michael ; Berger, Adam ; Hamilton, Richard ; Misch, David ; Moon, Suk Jin ; Sutherland, Dawn ; Dilts, Vera ; Henderson, Sara ; Medina, Esmeralda ; Trueman, Donald ; Holm, Laura ; Strickland, Jason ; Ie, Darmakusuma ; Lipkowitz, Jeffrey L. ; Shah, Kekul B. ; Geraghty, Susan ; Sannazzaro, Beverly ; Harper, Morgan ; Bayer, Krista ; Lansing, Mary B. ; Fox, Lauren B. ; Lee, Rebecca ; Stallman, Jay B. ; Jacobson, Michael ; Koh, Sean ; Lampert, Scott ; Miller, John ; Rivellese, Mark ; Sharma, Atul ; Stoltz, Robert A. ; Vanderveldt, Stephanie ; Marcus, Leslie ; Hendricks, Starr ; Hollman, Ryan ; Betanzos, Grethel ; Ellorin, Leslie ; Fulbright, Shelly ; McCormick, Debbie ; Edwards, Paul A. ; Hall, Julianne ; Monk, Mary ; Gutkowski, Melanie ; Mazurek, Melina ; Murphy, Janet ; Gusas, Katherine ; Moffett, Crystal ; Burley, David ; Chesney, Nicole ; Kilgo, Katie ; Rusinek, Brian ; Stern, Bradley ; Troszak, Tracy ; Baker-Levingston, Rhonda ; Baker, Carl W. ; Caldwell, Tracey ; Walker, Tammy ; Lambert, Lynnette F. ; Martin, Tracey ; Palmer, Mary Jill ; Williams, Tana ; Novak, Michael A. ; Coney, Joseph ; Miller, David G. ; Pendergast, Scott ; Singerman, Lawrence ; Zakov, Nicholas ; Zegarra, Hernando ; DuBois, Kim ; Rath, Susan ; Revella, Lori ; Brink, Tammy ; Drury, Kim ; Hogue, Lisa ; Ilc, Mary ; Keller, Connie ; McNamara, Elizabeth ; Tanner, Vivian ; Cunningham, Tamara ; DuBois, John ; Greanoff, Gregg ; Nitzsche, Trina ; Smith-Brewer, Sheila ; Isernhagen, Ricky D. ; Kitchens, John W. ; Stone, Thomas W. ; Wood, William J. ; Holcomb, Diana ; Therrien, Virginia ; Buck, Michelle ; Van Arsdall, Jeanne ; Slade, Edward ; Schneiderman, Todd E. ; Spinak, David J. ; Gaedke, Jackie ; Brown, Heather Davis ; Helgren, Dan ; Pangelinan, Jenifer Garrison ; Halperin, Lawrence ; Anagnoste, Scott ; Dhalla, Mandeep ; Rosenberg, Krista ; Taney, Barry ; Thompson, W. Scott ; Lopez, Jaclyn ; Hamlin, Monica ; Lopez, Monica ; Mariano, Jamie ; Quinchia, Evelyn ; Aramayo, Patricia ; Veksler, Rita ; Lee, Michael ; Dreyer, Richard ; Handelman, Irvin ; Ma, Colin ; Peters, Mark ; Hobbs, Stephen ; Milliron, Amanda ; Kopfer, Marcia ; Connaughton, Michele ; Hoerner, A. Christine ; Logan, R. Joseph ; Wohlsein, Harry J. ; Boyer, David ; Chu, Thomas G. ; Dayani, Pouya ; Liao, David ; Novack, Roger L. ; Rahhal, Firas M. ; Roe, Richard ; Tabandeh, Homayoun ; Bayramyan, Janet ; Gasparyan, Tammy ; Hoang, Connie ; Kurokouchi, Janet ; Lo, Tammy Eileen ; Ngo, Richard ; Nguyen, Mary Ann ; Peyton, Michael ; Yoon, Charles ; Sierra, Julio ; Zamboni, Adam ; Kessinger, Jeff ; Protacio, Eric ; Smucker, Adam ; Rath, Pamela ; Bergren, Robert ; Doft, Bernard ; Liu, Judy ; Olsen, Karl ; Merlotti, Lori ; Ingram, Willia ; Marfisi, Kellianne ; Yeckel, Kimberly ; Carmelo, Heather Schultz ; Fec, Amanda ; McBroom, Keith ; Steinberg, David ; Levy, Marc ; Abrams, Jody ; Chen, Melvin ; Torres, Waldemar ; Jelemensky, Peggy ; Prybylski, Mark ; Raphael, Tara ; Appleby, Diana ; Rodman, Charlotte ; Sneath, Mark ; Rosa, Robert H. ; Hoelscher, Vanessa ; Castano, Adelia ; Parker, Jocelyn ; Hoskins, John ; Anderson, Nicholas ; Googe, Joseph ; McMillan, Tod A. ; Miller, James ; Perkins, Stephen ; Oliver, Kristina ; Beerbower, Jennifer ; Gilliland, Bruce ; Hunt, Cecile ; Jacobus, Mike ; Lince, Raul ; Morris, Christopher ; Oelrich, Sarah ; Whetstone, Jerry ; Chan, Clement K. ; Lin, Steven ; Walther, Kim ; Gonzales, Tiana ; Myers, Lenise ; Huff, Kenneth ; Brown, David M. ; Chen, Eric ; Benz, Matthew S. ; Fish, Richard H. ; Kim, Rosa Y. ; Major, James ; Wong, Tien Pei ; Wycoff, Charles ; Cone, Cassandra ; Gilaspia, Debbie Goates ; Landaverde, Nubia ; Smith, Robert ; Zamora, Deneva ; Sneed, Veronica ; Vela, Melina ; Kegley, Eric ; Greven, Craig ; Kurup, Shree ; Richards, Charles ; Slusher, Madison ; Everhart, Cara ; Fish, Joan ; Miller, David ; Tyler, Marshall ; Lujan, Brandon ; Fu, Arthur D. ; Johnson, Robert N. ; Lujan, Brandon ; McDonald, H. Richard ; Rodriguez, Rosa ; Ansari, Nina ; Joaquin, Jeanifer ; Linares, Silvia ; Lopez, Lizette ; Sabio, Jessica ; Grout, Sean ; Indermill, Chad ; Urias, Yesmin ; Zimmerman, Roberto ; Margulies, Linda ; Schmidt, Sara J. ; Meier, Joy L. ; Hadley, Sherry L. ; Rosenthal, William ; Johnson, Barbara ; Swafford, Lois ; Shields, Richard ; Varner, R. Scott ; Rosen, Richard ; Gentile, Ronald ; Rivas, Melissa ; Tai, Katy W. ; Carrasquillo-Boyd, Wanda ; Masini, Robert ; Stoller, Glenn ; Carnevale, Ken ; LaRosa, Diane M. ; Burger, Barbara ; Conway, Tereza ; Del Castillo, Carla ; Diaz, Julissa ; Jones, Susan ; Mondoc, Nina ; Balfour, Charlene ; Vitha, C. H. ; Lutz, Jennifer ; McGinley, Barbara ; El Baba, Fadi ; Lavorna, Ann Marie ; Jones, Renee ; Lewis, Jean ; Tenzler, Ruth ; Salvas-Mladek, Mary ; Van Kesteren, Diane ; McLean, W. Copley ; Bridges, W. Zachery ; Stone, Cameron ; Ammons, Denise ; Lamy, Mary ; Menzel, Andrea ; Raymer, Lea Doll ; Campbell, Barbara ; Hawkins, Lisa ; Rickman, Leslie ; Sherlin, Lorraine ; Price, Paula ; Sinyai, Albert ; Kingsley, Ronald ; Bradford, Reagan H. ; Leonard, Robert E. ; Icks, Sonny ; Bergman, Vanessa ; Ross, Brittany ; Burris, Russ ; Butt, Amanda ; Richmond, Rob ; Lyon, Alice ; Gill, Manjot ; Jampol, Lee ; Mizra, Rukhsana ; Rozenbajgier, Zuzanna ; Chapman, Jeremy ; Kaminski, Lori ; Degillio, Andrea ; Simjanoski, Evica ; Heier, Jeffrey ; Cho, Hyung ; Cleary, Tina Scheufele ; Goldman, Darin ; Shah, Chirag ; Topping, Trexler ; Weber, Marissa ; Wiegand, Torsten ; Schindelheim, Jeremy ; Bankert, Joy ; Stone, Jennifer ; Nowak, Alison ; Chong, Sandy ; Williams, Lindsay ; Bennett, Steven ; Donovan, Dennis ; Graham, Margaret ; Jones, Cullen ; Fung, Anne ; Bayabo, Jan Kristine ; Bosch, Razelda ; Cruz, Esperanza ; Emerson, Ashley ; Fleming, Alycia ; Barsness, Denice ; Rodriguez, Jorge ; Soboleva, Marina ; Scott, Ingrid U. ; Bowie, Esther ; Neely, Kimberly A. ; Quillen, David A. ; Walter, Laura ; Bennett, Timothy ; Strong, James ; Wells, John ; Clark, Lloyd ; Miller, Peggy ; Taylor, Mallie ; Swinford, Tiffany ; Spivey, Robbin ; Banach, Michael ; Ho, Lawrence ; Lanning, Richard ; Pheasant, Thomas R. ; Prensky, Jay G. ; Truong, Steven ; Teatsworth, Julia ; Dietrich, Michelle ; Wasilus, Ann ; Miller, Ann ; Rakes, Megan ; Slagle, Teresa ; Richards, Michelle ; Schuessler, Patricia ; Stover, Lacy ; Beer, Paul ; Falk, Naomi S. ; Shannon, Mary Beth ; Olmeda, Jeannie ; Berdeen, Don ; Fisher, Joseph F. ; Folk, James ; Russell, Stephen ; Taylor, Barbara ; Hinz, Connie ; Walshire, Jean ; Stockman, Heather ; Critser, Bruce ; Karakas, Stefani ; Montague, Cindy ; Verdick, Randy ; Gupta, Omesh ; Maguire, Joseph ; Brady, Christopher ; DeCroos, Francis Char ; Dollin, Michael ; Garg, Sunir ; Gerstenblith, Adam ; Haller, Julia ; Ho, Allen C. ; Hsu, Jason ; Kaiser, Richard ; Pitcher, John ; Regillo, Carl ; Shah, Rajiv ; Spirn, Marc ; Tasman, William ; Vander, James ; Senderowitsch, Noga ; Formoso, Michele ; Markun, Michelle ; George, Cedric ; Centinaro, Christina ; Grande, Lisa ; Carey, Stefanie ; Liebenbaum, Elaine ; Sadda, Srini Vas ; Humayun, Mark ; Sierra, Rachel ; Corona, Elizabeth ; Padilla, Margaret ; Nu, Moonseok ; Ramos, Sylvia ; Barnett, Cullen ; Currie, Glenn ; Gottlieb, Cornelia ; Garfinkel, Richard ; Berinstein, Daniel ; Colyer, Marcus ; Deegan, William ; Min-Shyue Lai, Michael ; Murphy, Robert ; Osman, Michael ; Rivers, Michael ; Sanders, Reginald ; von Fricken, Manfred A. ; Oliver, Debbie ; Kirshon, Jeanne ; Snowden, Tanya Alexander ; Blondo, Thomas ; Cronise, Alysia ; Denny, Vanessa ; Mendez, Kylie ; Newgen, Janine ; Davis, Justin ; Flory, Mike ; Frantz, Robert ; Murphy, Bryan ; Rauch, Steve ; Kim, Judy E. ; Bachman, Jane ; Connor, Thomas B. ; Han, Dennis P. ; Stepian, Kimberly ; Weinberg, David V. ; Wirostko, William J. ; Packard, Krissa ; Kaczanowski, Tracy ; Williams, Vesper ; Barwick, Vicki ; Flanders, Judy ; Backes, Dennis ; Beringer, Joe ; Keller, Kristy ; Selchert, Kathy ; Bernstein, Paul ; Teske, Michael ; Vitale, Albert ; Allman, Susan ; Carlstrom, Bonnie ; Wegner, Kimberley ; Haroldsen, Anne ; Harrison, Deborah ; Fry, Cyrie ; Gilman, James ; Jenkins, Glen ; Morris, Paula ; Rauser, Michael ; Fan, Joseph ; Suthar, Mukesh ; Santiago, Gisela ; Halsey, Kara Rollins ; Quesada, Christy ; Kiernan, William ; Knabb, Jesse ; Lewis, Richard Alan ; Dorenbach, Cindy ; Spencer, Steven ; Barnett, Dana ; Morales, Joseph ; Fishburne, Barron C. ; Gross, Jeffrey G. ; Magee, Michael A. ; Flowers, Amy ; McDowell, Angie ; Price, Randall ; Huang, Suber ; Tang, Johnny ; Wilker, Shawn ; Hornsby, Cherie ; Ferguson, Lisa ; Krogstad, Kirk ; Adamovsky, Riva ; Allchin, Peggy ; Carlton, Kathleen ; Clow, Claudia ; Sholtis, Kelly ; Burke, Stephanie ; Harrod, Mark ; Hrvatin, Stacie ; Pankhurst, Geoffrey ; Sabates, Nelson R. ; Cassell, Michael ; Desai, Komal ; Poulose, Abraham ; Sabates, Felix ; Chen, Yin ; 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Changelian-Aitken, Nina ; Corrada, Fernando ; Dubuque, Jason ; Iezzi, Raymond ; Bakri, Sophie J. ; Pulido, Jose S. ; Vogen, Diane ; Nielsen, Rebecca ; Berg, Karin ; Burrington, Jean ; Howard, Shannon ; Overend, Joan ; Krason, Zbigniew ; Lewison, Denise ; Link, Thomas ; Blinder, Kevin J. ; Engelbrecht, Nicholas E. ; Grand, M. Gilbert ; Joseph, Daniel P. ; Shah, Gaurav K. ; Smith, Bradley ; Thomas, Matthew ; Weeks, Rhonda ; Boyd, Lynda ; Gabel, Dana ; Adelman, Ron ; Huang, John ; Kempton, James ; Parnes, Aaron ; Dupont, Jennifer ; Perotti, Elizabeth ; Donaldson, Victoria ; Fong, Kenneth ; Ossorio, Pamela ; Agarwal, Anita ; Sternberg, Paul ; Owings, Sandy ; Adkins, Tony ; Lok, Elaine ; Munn, Garvin ; Skellie, Buddy ; Bhagat, Neelakshi ; Roy, Monique S. ; Zarbin, Marco ; Fay, Catherine ; Lazar, Michael ; Malpica, Beth ; Mikheyav, Tatiana ; Ulanski, Lawrence ; Lim, Jennifer ; Niec, Marcia ; Johnson, Tametha ; Ovando, Yesenia ; Carroll, Catherine Nail ; Janowicz, Mark ; Schwartz, Steven ; Cupp, David ; Gorin, Michael ; Heilweil, Gad ; Hosseini, Hamid ; Hubschman, Jean Pierre ; Kreiger, Allan ; McCannel, Tara Young ; Pan, Carolyn ; Sarraf, David ; Tsui, Irena ; Udoetek, Joshua ; Voleti, Vinad ; Hitchcock, Logan ; Ostrick, Rosaleen ; Chun, Melissa ; Kageyama, Jennie ; Davila, Nilo ; Lipka, Kristin ; Shin, Christina ; Owsley, Cynthia ; Albert, Michael ; Feist, Richard ; Mason, John ; Thomley, Martin ; Johnson, Angelia ; Clark, Mark ; Emond, Tracy ; Hamela, Joanna ; Marsh, Angela ; Searcey, Karen ; Rookard, Kia ; He, Yu Guang ; Ufret-Vincenty, Rafael L. ; Molai, Mike ; Anderson, William ; Horna, John ; Letson, Alan ; Cebulla, Colleen ; Chang, Susie ; Davidorf, Fred ; Salerno, Jill ; Sladoje, Laura ; Stetson, Christina ; Perry, Jeri ; Savage, Scott ; Toth, Cynthia ; Jaffe, Glenn ; Schuman, Stefanie ; Sarin, Neeru ; Crowell, Jim ; Keaton, Tiffanie ; Kelly, Michael ; Lutman, Brian ; Skelly, Marriner ; Welch, Lauren ; Morse, Lawrence ; Hunter, Allan ; Soon-Chun Park, Susanna ; Wallace, Cynthia ; Dhillon, Ember ; Salvador, Marisa ; Holderreed, Barbara ; Chandra, Karishma ; Kaur, Sashi ; Redenbo, Ellen ; Hom, Smiley ; Cooney, Michael ; Barbazetto, Irene ; Klancnik, James M. ; Sorenson, John A. ; Yannuzzi, Lawrence ; Scolaro, Maria ; Agresta, Eugene ; Gonzalez, Nancy ; Grover, Sandeep ; Chalam, K. V. ; Gupta, Shailesh ; Lyons, Christopher ; Li, Wenhua ; Patel, Chirag ; Carrion, Jose ; Ferreyra, Henry ; Rodriguez, Amberly ; Molina, Iliana ; Balea, Gabriel ; Emory, Pam ; Rico, Marlene ; Siqueiros, Giorgio ; Brucker, Alexander J. ; Dunaief, Joshua ; Grunwald, Juan ; Kim, Benjamin ; Maguire, Albert M. ; VanderBeek, Brian ; Drossner, Sheri ; DuPont, Joan ; Salvo, Rebecca ; Berger, Jim ; Devine, Cheryl ; Nyberg, Bill ; Weeney, Laurel ; DiLoreto, David ; Chung, Mina ; Davis, Valerie ; MacDowell, Peter ; Gara, George O. ; Castillo, Daniel ; Czubinski, Andrea ; Keim, Melissa ; Hardy, Brandi ; Hollar, Rachel Grunhaus ; Schueckler, Lynn ; Lyon, Alice T. ; Weinberg, Aaron ; Shiloach, Mira ; Pelkofer, Nicole ; Zhou, Qin ; McPoland, Laura ; Apte, Rajendra ; Rao, P. Kumar ; Pistorius, Sam ; Kambarian, Jamie ; Adcock, Eve ; Gould, Sarah ; Quinn, Melanie ; Curtis, Rhonda ; Frost, Amy ; Meyer, Charla ; Rathert, Greg. / Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration : Age-Related Eye Disease Study 2 Report No. 17. In: Ophthalmology. 2018.
@article{d0f2679381fa4c7988e803c21afc0055,
title = "Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17",
abstract = "Purpose: To investigate the natural history and genetic associations of drusenoid pigment epithelial detachment (DPED) associated with age-related macular degeneration (AMD). Design: Retrospective analysis of a prospective cohort study. Participants: Of the 4203 Age-Related Eye Disease Study 2 (AREDS2) participants, 391 eyes (325 participants) had DPED without late AMD at the time of DPED detection. Genetic analyses included 120 white AREDS2 participants and 145 Age-Related Eye Disease Study (AREDS) participants with DPED. Methods: Baseline and annual stereoscopic fundus photographs were graded centrally to detect DPED, a well-defined yellow elevated mound of confluent drusen ≥433 μm in diameter, and to evaluate progression rates to late AMD: geographic atrophy (GA) and neovascular (NV)-AMD. Five single nucleotide polymorphisms (CFH [rs10611670], C3 [rs2230199], CFI [rs10033900], C2/CFB [rs114254831], ARMS2 [rs10490924]) and genetic risk score (GRS) group were investigated for association with DPED development. Kaplan–Meier analyses and multivariable proportional hazard regressions were performed. Main Outcome Measures: Progression rates to late AMD and decrease of ≥3 lines in visual acuity (VA) from the time of DPED detection; association of rate of DPED development with genotype. Results: Mean (standard deviation [SD]) follow-up time from DPED detection was 4.7 (0.9) years. DPED was associated with increased risk of progression to late AMD (hazard ratio [HR], 2.36; 95{\%} confidence interval [CI], 1.98–2.82; P < 0.001); 67{\%} of eyes progressed to late AMD 5 years after DPED detection. Drusenoid pigment epithelial detachment was associated with increased risk of ≥3 lines of VA loss (HR, 3.08; CI, 2.41–3.93; P < 0.001) with 46{\%} of eyes experiencing vision loss at 5 years (with or without progression to late AMD). ARMS2 risk alleles (1 vs. 0: HR, 2.72, CI, 1.58–4.70; 2 vs. 0: HR, 3.16, CI, 1.60–6.21, P < 0.001) and increasing GRS group (4 vs. 1) (HR, 12.17, CI, 3.66–40.45, P < 0.001) were significantly associated with DPED development in AREDS. There were no significant genetic results in AREDS2. Conclusions: This study replicates the results of previous natural history studies of eyes with DPED including the high rates of progression to late AMD and vision loss (regardless of progression to late AMD). The genetic associations are consistent with genes associated with AMD progression.",
author = "Yu, {Jeannette J.} and Elvira Agr{\'o}n and Clemons, {Traci E.} and Amitha Domalpally and {van Asten}, Freekje and Keenan, {Tiarnan D.} and Catherine Cukras and Chew, {Emily Y.} and Chew, {Emily Y.} and Ferris, {Frederick L.} and SanGiovanni, {John Paul} and Elvira Agr{\'o}n and Traci Clemons and Anne Lindblad and Robert Lindblad and Nilay Shah and Robert Sperduto and Wendy McBee and Gary Gensler and Molly Harrington and Alice Henning and Katrina Jones and Kumar Thotapally and Diana Tull and Valerie Watson and Kayla Williams and Christina Gentry and Francine Kaufman and Chris Morrison and Elizabeth Saverino and Sherrie Schenning and Barbara Blodi and Matthew Davis and Amitha Domalpally and Kathy Glander and Gregory Guilfoil and Hubbard, {Larry D.} and Kristine Johnson and Barbara Nardi and Michael Neider and Nancy Robinson and Eileen Rosensteel and Hugh Wabers and Grace Zhang and Antonio Capone and Bawa Dass and Kimberly Drenser and Garretson, {Bruce R.} and Hassan, {Tarek S.} and Michael Trese and Williams, {George A.} and Jeremy Wolfe and Tina Bell and Mary Zajechowski and Dennis Bezaire and Fran McIver and Anthony Medina and Jackie Pagett and Smith, {Stephanie Hatch} and Lynn Swartz and Tom Treuter and Andrew Antoszyk and Justin Brown and Browning, {David J.} and Walter Holland and Angella Karow and Kelly Stalford and Angela Price and Sarah Ennis and Sherry Fredenberg and Jenna Herby and Uma Balasubramaniam and Loraine Clark and Donna McClain and Michael McOwen and Lynn Watson and Michael Klein and Steven Bailey and Hwang, {Thomas J.} and Lauer, {Andreas (Andy)} and Stout, {J. Timothy} and Patty McCollum and Milt Johnson and Rice, {Patrick B.} and Ivana Kim and John Loewenstein and Joan Miller and Lucia Sobrin and Lucy Young and Jacqueline Sullivan and Patricia Houlihan and Linda Merry and Lane, {Ann Marie} and Bator, {Ursula Lord} and Claudia Evans and Sarah Brett and Charleen Callahan and Marcia Grillo and David Walsh and Zimmerman, {Kamella Lau} and Rajiv Anand and Coors, {Lori E.} and Fuller, {Dwain G.} and Rand Spencer and Wang, {Robert C.} and Karen Duignan and Sally Arceneaux and Hank Aguado and Nicholas Hesse and Michael Mackens and Brian Swan and Wong, {Wai T.} and Catherine Cukras and Monica Dalal and Naima Jacobs-El and Catherine Meyerle and Benjamin Nicholson and Henry Wiley and Shimel, {Katherine Hall} and Angel Garced and Janice Oparah and Greg Short and Alana Temple and Babilonia Ayukawa and Guy Foster and Darryl Hayes and Dessie Koutsandreas and Roula Nashwinter and John Rowan and Michael Bono and Denise Cunningham and Marilois Palmer and Alicia Zetina and Orth, {David H.} and Kourous Rezaei and Joseph Civantos and Sohail Hasan and Kirk Packo and Celeste Figliulo and Pam Stanberry and Tara Farmer and Kiersten Nelson and Shannya Townsend-Patrick and Philip Rosenfeld and Royce Chen and Rishi Doshi and Sander Dubovy and Kim, {Brian T.} and Matthew Lowrance and Andrew Moshfeghi and Zayna Nahas and Gary Schienbaum and John Vishak and Christina Weng and Zohar Yehoshua and Belen Rodriguez and Jose Rebimbas and Jane Gleichauf and Mike Kicak and Jason Mena and Tim Odem and Elizabeth Sferza-Camp and Alicia Disgdiertt and Jim Oramas and Isabel Rams and Stephanie Thatcher and Bressler, {Susan B.} and Bressler, {Neil M.} and Daniel Finkelstein and Sherman, {Steven H.} and Sharon Solomon and Ying, {Howard S.} and Rita Denbow and Deborah Phillips and Elizabeth Radcliffe and Judy Belt and Dennis Cain and David Emmert and Mark Herring and Jacquelyn McDonald and Hubbard, {G. Baker} and Bergstrom, {Chris S.} and Blaine Cribbs and Andrew Hendrick and Brandon Johnson and Philip Laird and Sonia Mehta and Timothy Olsen and Justin Townsend and Jion Yan and Steven Yeh and Linda Curtis and Judy Brower and Hannah Yi and Dobbs, {Jannah Rutter} and Debbie Jordan and Elman, {Michael J.} and Liss, {Robert A.} and Starr, {Jo Ann} and Jennifer Belz and Charlene Putzulo and Teresa Coffey and Ashley Davis and Pamela Singletary and Andreani, {Giorya Shabi} and Theresa Cain and Daniel Ketner and Peter Sotirakos and Suresh Chandra and Blodi, {Barbara A.} and Altaweel, {Michael M.} and Danis, {Ronald P.} and Gottlieb, {Justin L.} and Michael Ip and Ronald Klein and Nork, {T. Michael} and Stevens, {Thomas S.} and Kathryn Burke and Shelly Olson and Kristine Dietzman and Barbara Soderling and Guy Somers and Angie Wealti and Denise Krolnik and John Peterson and Sandra Reed and Thomas Friberg and Andrew Eller and Denise Gallagher and Leanne Labriola and Melissa Pokrifka and Aron Gedansky and Natalie Anthony and Cassandra Grzybowski and Dawn Matthews and Sharon Murajda-Jumba and Jessica Toro and Callanan, {David G.} and Solley, {Wayne A.} and Patrick Williams and Sandy Lash and Bob Boleman and Chris Dock and Fish, {Gary Edd} and Michel Shami and Brenda Arrington and Ashaki Meeks and Margherio, {Alan R.} and Paul Raphaelian and Debra Markus and Justin Langdon and Elizabeth Truax and Sandy Lewis and Brad Terry and Ruby, {Alan J.} and Amy Noffke and Kean Oh and Ramin Sarrafizadeh and Scott Sneed and Julie Hammersley and Serena Neal and Mary Doran and Nan Jones and Lisa Preston and Heather Jessick and Marsh, {Tanya Tracy} and Michael Tolentino and Adam Berger and Richard Hamilton and David Misch and Moon, {Suk Jin} and Dawn Sutherland and Vera Dilts and Sara Henderson and Esmeralda Medina and Donald Trueman and Laura Holm and Jason Strickland and Darmakusuma Ie and Lipkowitz, {Jeffrey L.} and Shah, {Kekul B.} and Susan Geraghty and Beverly Sannazzaro and Morgan Harper and Krista Bayer and Lansing, {Mary B.} and Fox, {Lauren B.} and Rebecca Lee and Stallman, {Jay B.} and Michael Jacobson and Sean Koh and Scott Lampert and John Miller and Mark Rivellese and Atul Sharma and Stoltz, {Robert A.} and Stephanie Vanderveldt and Leslie Marcus and Starr Hendricks and Ryan Hollman and Grethel Betanzos and Leslie Ellorin and Shelly Fulbright and Debbie McCormick and Edwards, {Paul A.} and Julianne Hall and Mary Monk and Melanie Gutkowski and Melina Mazurek and Janet Murphy and Katherine Gusas and Crystal Moffett and David Burley and Nicole Chesney and Katie Kilgo and Brian Rusinek and Bradley Stern and Tracy Troszak and Rhonda Baker-Levingston and Baker, {Carl W.} and Tracey Caldwell and Tammy Walker and Lambert, {Lynnette F.} and Tracey Martin and Palmer, {Mary Jill} and Tana Williams and Novak, {Michael A.} and Joseph Coney and Miller, {David G.} and Scott Pendergast and Lawrence Singerman and Nicholas Zakov and Hernando Zegarra and Kim DuBois and Susan Rath and Lori Revella and Tammy Brink and Kim Drury and Lisa Hogue and Mary Ilc and Connie Keller and Elizabeth McNamara and Vivian Tanner and Tamara Cunningham and John DuBois and Gregg Greanoff and Trina Nitzsche and Sheila Smith-Brewer and Isernhagen, {Ricky D.} and Kitchens, {John W.} and Stone, {Thomas W.} and Wood, {William J.} and Diana Holcomb and Virginia Therrien and Michelle Buck and {Van Arsdall}, Jeanne and Edward Slade and Schneiderman, {Todd E.} and Spinak, {David J.} and Jackie Gaedke and Brown, {Heather Davis} and Dan Helgren and Pangelinan, {Jenifer Garrison} and Lawrence Halperin and Scott Anagnoste and Mandeep Dhalla and Krista Rosenberg and Barry Taney and Thompson, {W. Scott} and Jaclyn Lopez and Monica Hamlin and Monica Lopez and Jamie Mariano and Evelyn Quinchia and Patricia Aramayo and Rita Veksler and Michael Lee and Richard Dreyer and Irvin Handelman and Colin Ma and Mark Peters and Stephen Hobbs and Amanda Milliron and Marcia Kopfer and Michele Connaughton and Hoerner, {A. Christine} and Logan, {R. Joseph} and Wohlsein, {Harry J.} and David Boyer and Chu, {Thomas G.} and Pouya Dayani and David Liao and Novack, {Roger L.} and Rahhal, {Firas M.} and Richard Roe and Homayoun Tabandeh and Janet Bayramyan and Tammy Gasparyan and Connie Hoang and Janet Kurokouchi and Lo, {Tammy Eileen} and Richard Ngo and Nguyen, {Mary Ann} and Michael Peyton and Charles Yoon and Julio Sierra and Adam Zamboni and Jeff Kessinger and Eric Protacio and Adam Smucker and Pamela Rath and Robert Bergren and Bernard Doft and Judy Liu and Karl Olsen and Lori Merlotti and Willia Ingram and Kellianne Marfisi and Kimberly Yeckel and Carmelo, {Heather Schultz} and Amanda Fec and Keith McBroom and David Steinberg and Marc Levy and Jody Abrams and Melvin Chen and Waldemar Torres and Peggy Jelemensky and Mark Prybylski and Tara Raphael and Diana Appleby and Charlotte Rodman and Mark Sneath and Rosa, {Robert H.} and Vanessa Hoelscher and Adelia Castano and Jocelyn Parker and John Hoskins and Nicholas Anderson and Joseph Googe and McMillan, {Tod A.} and James Miller and Stephen Perkins and Kristina Oliver and Jennifer Beerbower and Bruce Gilliland and Cecile Hunt and Mike Jacobus and Raul Lince and Christopher Morris and Sarah Oelrich and Jerry Whetstone and Chan, {Clement K.} and Steven Lin and Kim Walther and Tiana Gonzales and Lenise Myers and Kenneth Huff and Brown, {David M.} and Eric Chen and Benz, {Matthew S.} and Fish, {Richard H.} and Kim, {Rosa Y.} and James Major and Wong, {Tien Pei} and Charles Wycoff and Cassandra Cone and Gilaspia, {Debbie Goates} and Nubia Landaverde and Robert Smith and Deneva Zamora and Veronica Sneed and Melina Vela and Eric Kegley and Craig Greven and Shree Kurup and Charles Richards and Madison Slusher and Cara Everhart and Joan Fish and David Miller and Marshall Tyler and Brandon Lujan and Fu, {Arthur D.} and Johnson, {Robert N.} and Brandon Lujan and McDonald, {H. Richard} and Rosa Rodriguez and Nina Ansari and Jeanifer Joaquin and Silvia Linares and Lizette Lopez and Jessica Sabio and Sean Grout and Chad Indermill and Yesmin Urias and Roberto Zimmerman and Linda Margulies and Schmidt, {Sara J.} and Meier, {Joy L.} and Hadley, {Sherry L.} and William Rosenthal and Barbara Johnson and Lois Swafford and Richard Shields and Varner, {R. Scott} and Richard Rosen and Ronald Gentile and Melissa Rivas and Tai, {Katy W.} and Wanda Carrasquillo-Boyd and Robert Masini and Glenn Stoller and Ken Carnevale and LaRosa, {Diane M.} and Barbara Burger and Tereza Conway and {Del Castillo}, Carla and Julissa Diaz and Susan Jones and Nina Mondoc and Charlene Balfour and Vitha, {C. H.} and Jennifer Lutz and Barbara McGinley and {El Baba}, Fadi and Lavorna, {Ann Marie} and Renee Jones and Jean Lewis and Ruth Tenzler and Mary Salvas-Mladek and {Van Kesteren}, Diane and McLean, {W. Copley} and Bridges, {W. Zachery} and Cameron Stone and Denise Ammons and Mary Lamy and Andrea Menzel and Raymer, {Lea Doll} and Barbara Campbell and Lisa Hawkins and Leslie Rickman and Lorraine Sherlin and Paula Price and Albert Sinyai and Ronald Kingsley and Bradford, {Reagan H.} and Leonard, {Robert E.} and Sonny Icks and Vanessa Bergman and Brittany Ross and Russ Burris and Amanda Butt and Rob Richmond and Alice Lyon and Manjot Gill and Lee Jampol and Rukhsana Mizra and Zuzanna Rozenbajgier and Jeremy Chapman and Lori Kaminski and Andrea Degillio and Evica Simjanoski and Jeffrey Heier and Hyung Cho and Cleary, {Tina Scheufele} and Darin Goldman and Chirag Shah and Trexler Topping and Marissa Weber and Torsten Wiegand and Jeremy Schindelheim and Joy Bankert and Jennifer Stone and Alison Nowak and Sandy Chong and Lindsay Williams and Steven Bennett and Dennis Donovan and Margaret Graham and Cullen Jones and Anne Fung and Bayabo, {Jan Kristine} and Razelda Bosch and Esperanza Cruz and Ashley Emerson and Alycia Fleming and Denice Barsness and Jorge Rodriguez and Marina Soboleva and Scott, {Ingrid U.} and Esther Bowie and Neely, {Kimberly A.} and Quillen, {David A.} and Laura Walter and Timothy Bennett and James Strong and John Wells and Lloyd Clark and Peggy Miller and Mallie Taylor and Tiffany Swinford and Robbin Spivey and Michael Banach and Lawrence Ho and Richard Lanning and Pheasant, {Thomas R.} and Prensky, {Jay G.} and Steven Truong and Julia Teatsworth and Michelle Dietrich and Ann Wasilus and Ann Miller and Megan Rakes and Teresa Slagle and Michelle Richards and Patricia Schuessler and Lacy Stover and Paul Beer and Falk, {Naomi S.} and Shannon, {Mary Beth} and Jeannie Olmeda and Don Berdeen and Fisher, {Joseph F.} and James Folk and Stephen Russell and Barbara Taylor and Connie Hinz and Jean Walshire and Heather Stockman and Bruce Critser and Stefani Karakas and Cindy Montague and Randy Verdick and Omesh Gupta and Joseph Maguire and Christopher Brady and DeCroos, {Francis Char} and Michael Dollin and Sunir Garg and Adam Gerstenblith and Julia Haller and Ho, {Allen C.} and Jason Hsu and Richard Kaiser and John Pitcher and Carl Regillo and Rajiv Shah and Marc Spirn and William Tasman and James Vander and Noga Senderowitsch and Michele Formoso and Michelle Markun and Cedric George and Christina Centinaro and Lisa Grande and Stefanie Carey and Elaine Liebenbaum and Sadda, {Srini Vas} and Mark Humayun and Rachel Sierra and Elizabeth Corona and Margaret Padilla and Moonseok Nu and Sylvia Ramos and Cullen Barnett and Glenn Currie and Cornelia Gottlieb and Richard Garfinkel and Daniel Berinstein and Marcus Colyer and William Deegan and {Min-Shyue Lai}, Michael and Robert Murphy and Michael Osman and Michael Rivers and Reginald Sanders and {von Fricken}, {Manfred A.} and Debbie Oliver and Jeanne Kirshon and Snowden, {Tanya Alexander} and Thomas Blondo and Alysia Cronise and Vanessa Denny and Kylie Mendez and Janine Newgen and Justin Davis and Mike Flory and Robert Frantz and Bryan Murphy and Steve Rauch and Kim, {Judy E.} and Jane Bachman and Connor, {Thomas B.} and Han, {Dennis P.} and Kimberly Stepian and Weinberg, {David V.} and Wirostko, {William J.} and Krissa Packard and Tracy Kaczanowski and Vesper Williams and Vicki Barwick and Judy Flanders and Dennis Backes and Joe Beringer and Kristy Keller and Kathy Selchert and Paul Bernstein and Michael Teske and Albert Vitale and Susan Allman and Bonnie Carlstrom and Kimberley Wegner and Anne Haroldsen and Deborah Harrison and Cyrie Fry and James Gilman and Glen Jenkins and Paula Morris and Michael Rauser and Joseph Fan and Mukesh Suthar and Gisela Santiago and Halsey, {Kara Rollins} and Christy Quesada and William Kiernan and Jesse Knabb and Lewis, {Richard Alan} and Cindy Dorenbach and Steven Spencer and Dana Barnett and Joseph Morales and Fishburne, {Barron C.} and Gross, {Jeffrey G.} and Magee, {Michael A.} and Amy Flowers and Angie McDowell and Randall Price and Suber Huang and Johnny Tang and Shawn Wilker and Cherie Hornsby and Lisa Ferguson and Kirk Krogstad and Riva Adamovsky and Peggy Allchin and Kathleen Carlton and Claudia Clow and Kelly Sholtis and Stephanie Burke and Mark Harrod and Stacie Hrvatin and Geoffrey Pankhurst and Sabates, {Nelson R.} and Michael Cassell and Komal Desai and Abraham Poulose and Felix Sabates and Yin Chen and Gary Gallimore and Yolanda Konior and Nicola Kim and Sami Uwaydat and Deborah Troillett and Karen Aletter and Frank, {Robert N.} and Gary Abrams and James Puklin and Asheesh Tewari and Cheryl Milanovic and Melanie Bailey and David Griffith and Dena McDonald and Kit Morehead and Zlatan Sadikovic and Lisa Schillace and Elizabeth Silvis and Brian Joondeph and Nancy Christmas and David Johnson and Alan Kimura and Mimi Liu and Stephen Petty and John Zilis and Jenny Benitez and Catlett, {Cassandra Berryman} and Eric Fluegel and Shane Mowry and Hoang Nguyen and David Reflow and Houghton, {Odette M.} and Seema Garg and Landers, {Maurice B.} and Travis Meredith and Sandy Barnhart and Megha Karmalkar and Debra Cantrell and Esquejo-Leon, {Rona Lyn} and Linda Manor and Sue Pope and David Stines and Amelia Stokely and Dean Hainsworth and Dyann Helming and Debbie Eichelberger and Leaton, {Mary Paige} and Chuck Hamm and Edward Chaum and Alessandro Iannaccone and Barbara Jennings and Tracy Murray and Joe Mastellone and Robert Millay and Brian Kim and Theresa Goddard and Beaudette, {Liza Jarrett} and Nina Changelian-Aitken and Fernando Corrada and Jason Dubuque and Raymond Iezzi and Bakri, {Sophie J.} and Pulido, {Jose S.} and Diane Vogen and Rebecca Nielsen and Karin Berg and Jean Burrington and Shannon Howard and Joan Overend and Zbigniew Krason and Denise Lewison and Thomas Link and Blinder, {Kevin J.} and Engelbrecht, {Nicholas E.} and Grand, {M. Gilbert} and Joseph, {Daniel P.} and Shah, {Gaurav K.} and Bradley Smith and Matthew Thomas and Rhonda Weeks and Lynda Boyd and Dana Gabel and Ron Adelman and John Huang and James Kempton and Aaron Parnes and Jennifer Dupont and Elizabeth Perotti and Victoria Donaldson and Kenneth Fong and Pamela Ossorio and Anita Agarwal and Paul Sternberg and Sandy Owings and Tony Adkins and Elaine Lok and Garvin Munn and Buddy Skellie and Neelakshi Bhagat and Roy, {Monique S.} and Marco Zarbin and Catherine Fay and Michael Lazar and Beth Malpica and Tatiana Mikheyav and Lawrence Ulanski and Jennifer Lim and Marcia Niec and Tametha Johnson and Yesenia Ovando and Carroll, {Catherine Nail} and Mark Janowicz and Steven Schwartz and David Cupp and Michael Gorin and Gad Heilweil and Hamid Hosseini and Hubschman, {Jean Pierre} and Allan Kreiger and McCannel, {Tara Young} and Carolyn Pan and David Sarraf and Irena Tsui and Joshua Udoetek and Vinad Voleti and Logan Hitchcock and Rosaleen Ostrick and Melissa Chun and Jennie Kageyama and Nilo Davila and Kristin Lipka and Christina Shin and Cynthia Owsley and Michael Albert and Richard Feist and John Mason and Martin Thomley and Angelia Johnson and Mark Clark and Tracy Emond and Joanna Hamela and Angela Marsh and Karen Searcey and Kia Rookard and He, {Yu Guang} and Ufret-Vincenty, {Rafael L.} and Mike Molai and William Anderson and John Horna and Alan Letson and Colleen Cebulla and Susie Chang and Fred Davidorf and Jill Salerno and Laura Sladoje and Christina Stetson and Jeri Perry and Scott Savage and Cynthia Toth and Glenn Jaffe and Stefanie Schuman and Neeru Sarin and Jim Crowell and Tiffanie Keaton and Michael Kelly and Brian Lutman and Marriner Skelly and Lauren Welch and Lawrence Morse and Allan Hunter and {Soon-Chun Park}, Susanna and Cynthia Wallace and Ember Dhillon and Marisa Salvador and Barbara Holderreed and Karishma Chandra and Sashi Kaur and Ellen Redenbo and Smiley Hom and Michael Cooney and Irene Barbazetto and Klancnik, {James M.} and Sorenson, {John A.} and Lawrence Yannuzzi and Maria Scolaro and Eugene Agresta and Nancy Gonzalez and Sandeep Grover and Chalam, {K. V.} and Shailesh Gupta and Christopher Lyons and Wenhua Li and Chirag Patel and Jose Carrion and Henry Ferreyra and Amberly Rodriguez and Iliana Molina and Gabriel Balea and Pam Emory and Marlene Rico and Giorgio Siqueiros and Brucker, {Alexander J.} and Joshua Dunaief and Juan Grunwald and Benjamin Kim and Maguire, {Albert M.} and Brian VanderBeek and Sheri Drossner and Joan DuPont and Rebecca Salvo and Jim Berger and Cheryl Devine and Bill Nyberg and Laurel Weeney and David DiLoreto and Mina Chung and Valerie Davis and Peter MacDowell and Gara, {George O.} and Daniel Castillo and Andrea Czubinski and Melissa Keim and Brandi Hardy and Hollar, {Rachel Grunhaus} and Lynn Schueckler and Lyon, {Alice T.} and Aaron Weinberg and Mira Shiloach and Nicole Pelkofer and Qin Zhou and Laura McPoland and Rajendra Apte and Rao, {P. Kumar} and Sam Pistorius and Jamie Kambarian and Eve Adcock and Sarah Gould and Melanie Quinn and Rhonda Curtis and Amy Frost and Charla Meyer and Greg Rathert",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.ophtha.2018.08.017",
language = "English (US)",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration

T2 - Age-Related Eye Disease Study 2 Report No. 17

AU - Yu, Jeannette J.

AU - Agrón, Elvira

AU - Clemons, Traci E.

AU - Domalpally, Amitha

AU - van Asten, Freekje

AU - Keenan, Tiarnan D.

AU - Cukras, Catherine

AU - Chew, Emily Y.

AU - Chew, Emily Y.

AU - Ferris, Frederick L.

AU - SanGiovanni, John Paul

AU - Agrón, Elvira

AU - Clemons, Traci

AU - Lindblad, Anne

AU - Lindblad, Robert

AU - Shah, Nilay

AU - Sperduto, Robert

AU - McBee, Wendy

AU - Gensler, Gary

AU - Harrington, Molly

AU - Henning, Alice

AU - Jones, Katrina

AU - Thotapally, Kumar

AU - Tull, Diana

AU - Watson, Valerie

AU - Williams, Kayla

AU - Gentry, Christina

AU - Kaufman, Francine

AU - Morrison, Chris

AU - Saverino, Elizabeth

AU - Schenning, Sherrie

AU - Blodi, Barbara

AU - Davis, Matthew

AU - Domalpally, Amitha

AU - Glander, Kathy

AU - Guilfoil, Gregory

AU - Hubbard, Larry D.

AU - Johnson, Kristine

AU - Nardi, Barbara

AU - Neider, Michael

AU - Robinson, Nancy

AU - Rosensteel, Eileen

AU - Wabers, Hugh

AU - Zhang, Grace

AU - Capone, Antonio

AU - Dass, Bawa

AU - Drenser, Kimberly

AU - Garretson, Bruce R.

AU - Hassan, Tarek S.

AU - Trese, Michael

AU - Williams, George A.

AU - Wolfe, Jeremy

AU - Bell, Tina

AU - Zajechowski, Mary

AU - Bezaire, Dennis

AU - McIver, Fran

AU - Medina, Anthony

AU - Pagett, Jackie

AU - Smith, Stephanie Hatch

AU - Swartz, Lynn

AU - Treuter, Tom

AU - Antoszyk, Andrew

AU - Brown, Justin

AU - Browning, David J.

AU - Holland, Walter

AU - Karow, Angella

AU - Stalford, Kelly

AU - Price, Angela

AU - Ennis, Sarah

AU - Fredenberg, Sherry

AU - Herby, Jenna

AU - Balasubramaniam, Uma

AU - Clark, Loraine

AU - McClain, Donna

AU - McOwen, Michael

AU - Watson, Lynn

AU - Klein, Michael

AU - Bailey, Steven

AU - Hwang, Thomas J.

AU - Lauer, Andreas (Andy)

AU - Stout, J. Timothy

AU - McCollum, Patty

AU - Johnson, Milt

AU - Rice, Patrick B.

AU - Kim, Ivana

AU - Loewenstein, John

AU - Miller, Joan

AU - Sobrin, Lucia

AU - Young, Lucy

AU - Sullivan, Jacqueline

AU - Houlihan, Patricia

AU - Merry, Linda

AU - Lane, Ann Marie

AU - Bator, Ursula Lord

AU - Evans, Claudia

AU - Brett, Sarah

AU - Callahan, Charleen

AU - Grillo, Marcia

AU - Walsh, David

AU - Zimmerman, Kamella Lau

AU - Anand, Rajiv

AU - Coors, Lori E.

AU - Fuller, Dwain G.

AU - Spencer, Rand

AU - Wang, Robert C.

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PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: To investigate the natural history and genetic associations of drusenoid pigment epithelial detachment (DPED) associated with age-related macular degeneration (AMD). Design: Retrospective analysis of a prospective cohort study. Participants: Of the 4203 Age-Related Eye Disease Study 2 (AREDS2) participants, 391 eyes (325 participants) had DPED without late AMD at the time of DPED detection. Genetic analyses included 120 white AREDS2 participants and 145 Age-Related Eye Disease Study (AREDS) participants with DPED. Methods: Baseline and annual stereoscopic fundus photographs were graded centrally to detect DPED, a well-defined yellow elevated mound of confluent drusen ≥433 μm in diameter, and to evaluate progression rates to late AMD: geographic atrophy (GA) and neovascular (NV)-AMD. Five single nucleotide polymorphisms (CFH [rs10611670], C3 [rs2230199], CFI [rs10033900], C2/CFB [rs114254831], ARMS2 [rs10490924]) and genetic risk score (GRS) group were investigated for association with DPED development. Kaplan–Meier analyses and multivariable proportional hazard regressions were performed. Main Outcome Measures: Progression rates to late AMD and decrease of ≥3 lines in visual acuity (VA) from the time of DPED detection; association of rate of DPED development with genotype. Results: Mean (standard deviation [SD]) follow-up time from DPED detection was 4.7 (0.9) years. DPED was associated with increased risk of progression to late AMD (hazard ratio [HR], 2.36; 95% confidence interval [CI], 1.98–2.82; P < 0.001); 67% of eyes progressed to late AMD 5 years after DPED detection. Drusenoid pigment epithelial detachment was associated with increased risk of ≥3 lines of VA loss (HR, 3.08; CI, 2.41–3.93; P < 0.001) with 46% of eyes experiencing vision loss at 5 years (with or without progression to late AMD). ARMS2 risk alleles (1 vs. 0: HR, 2.72, CI, 1.58–4.70; 2 vs. 0: HR, 3.16, CI, 1.60–6.21, P < 0.001) and increasing GRS group (4 vs. 1) (HR, 12.17, CI, 3.66–40.45, P < 0.001) were significantly associated with DPED development in AREDS. There were no significant genetic results in AREDS2. Conclusions: This study replicates the results of previous natural history studies of eyes with DPED including the high rates of progression to late AMD and vision loss (regardless of progression to late AMD). The genetic associations are consistent with genes associated with AMD progression.

AB - Purpose: To investigate the natural history and genetic associations of drusenoid pigment epithelial detachment (DPED) associated with age-related macular degeneration (AMD). Design: Retrospective analysis of a prospective cohort study. Participants: Of the 4203 Age-Related Eye Disease Study 2 (AREDS2) participants, 391 eyes (325 participants) had DPED without late AMD at the time of DPED detection. Genetic analyses included 120 white AREDS2 participants and 145 Age-Related Eye Disease Study (AREDS) participants with DPED. Methods: Baseline and annual stereoscopic fundus photographs were graded centrally to detect DPED, a well-defined yellow elevated mound of confluent drusen ≥433 μm in diameter, and to evaluate progression rates to late AMD: geographic atrophy (GA) and neovascular (NV)-AMD. Five single nucleotide polymorphisms (CFH [rs10611670], C3 [rs2230199], CFI [rs10033900], C2/CFB [rs114254831], ARMS2 [rs10490924]) and genetic risk score (GRS) group were investigated for association with DPED development. Kaplan–Meier analyses and multivariable proportional hazard regressions were performed. Main Outcome Measures: Progression rates to late AMD and decrease of ≥3 lines in visual acuity (VA) from the time of DPED detection; association of rate of DPED development with genotype. Results: Mean (standard deviation [SD]) follow-up time from DPED detection was 4.7 (0.9) years. DPED was associated with increased risk of progression to late AMD (hazard ratio [HR], 2.36; 95% confidence interval [CI], 1.98–2.82; P < 0.001); 67% of eyes progressed to late AMD 5 years after DPED detection. Drusenoid pigment epithelial detachment was associated with increased risk of ≥3 lines of VA loss (HR, 3.08; CI, 2.41–3.93; P < 0.001) with 46% of eyes experiencing vision loss at 5 years (with or without progression to late AMD). ARMS2 risk alleles (1 vs. 0: HR, 2.72, CI, 1.58–4.70; 2 vs. 0: HR, 3.16, CI, 1.60–6.21, P < 0.001) and increasing GRS group (4 vs. 1) (HR, 12.17, CI, 3.66–40.45, P < 0.001) were significantly associated with DPED development in AREDS. There were no significant genetic results in AREDS2. Conclusions: This study replicates the results of previous natural history studies of eyes with DPED including the high rates of progression to late AMD and vision loss (regardless of progression to late AMD). The genetic associations are consistent with genes associated with AMD progression.

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U2 - 10.1016/j.ophtha.2018.08.017

DO - 10.1016/j.ophtha.2018.08.017

M3 - Article

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

ER -