National trends in surgical procedures for hepatocellular carcinoma: 1998-2008

Hari Nathan, Dorry L. Segev, Skye Mayo, Michael A. Choti, Andrew M. Cameron, Christopher L. Wolfgang, Kenzo Hirose, Barish H. Edil, Richard D. Schulick, Timothy M. Pawlik

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

BACKGROUND: The incidence of hepatocellular carcinoma (HCC) is rising, and the options for surgical therapy of HCC have evolved recently, but use of surgical therapy has not been characterized on a representative, nationwide basis.We quantified trends in use, mortality, and patient and hospital characteristics for 3 surgical therapies for HCC (resection, ablation, and transplantation) in the United States from 1998 to 2008. METHODS: Hospital discharge data from the Nationwide Inpatient Sample were used to quantify procedure-related data for each year. Trends over time were summarized as the average annual percent change (AAPC) and corresponding 95% confidence interval (CI). RESULTS: The number of surgical procedures for HCC increased from 1416 to 6769 (AAPC, 13.5%; 95% CI, 10.2%-16.8%). Volumes increased for all surgical procedures, most notably for ablation (AAPC, 17.3%; 95% CI, 6.6%- 29.2%) and transplantation (AAPC, 20.9%; 95% CI, 14.1%-28.1%). When analyzed as a proportion of total procedures, there were declines in the relative use of major hepatectomy (35% to 16%; AAPC, -7.2%, 95% CI, -8.8% to -5.6%) and wedge resection (37% to 22%; AAPC, -4.8%; 95% CI, -6.2% to -3.4%), while the proportion accounted for by transplantation increased (16% to 35%; AAPC, 4.4%; 95% CI, 0.2%-8.9%). Inpatient mortality decreased for each procedure individually and overall from 7.3% to 4.6% (AAPC, -7.7%; 95% CI, -10.8% to -4.5%), despite increasing age and comorbidity burden. CONCLUSIONS: The use of surgical therapy for HCC has increased dramatically over the last decade, with a relative shift away from liver resection and toward liver transplantation. These therapeutic modalities must be better targeted to make the most appropriate use of limited health care resources.

Original languageEnglish (US)
Pages (from-to)1838-1844
Number of pages7
JournalCancer
Volume118
Issue number7
DOIs
StatePublished - Apr 1 2012
Externally publishedYes

Fingerprint

Hepatocellular Carcinoma
Confidence Intervals
Transplantation
Inpatients
Therapeutics
Health Resources
Hepatectomy
Hospital Mortality
Liver Transplantation
Comorbidity
Delivery of Health Care
Mortality
Liver
Incidence

Keywords

  • Hepatocellular carcinoma
  • Liver ablation
  • Liver resection
  • Liver transplantation
  • Surgery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Nathan, H., Segev, D. L., Mayo, S., Choti, M. A., Cameron, A. M., Wolfgang, C. L., ... Pawlik, T. M. (2012). National trends in surgical procedures for hepatocellular carcinoma: 1998-2008. Cancer, 118(7), 1838-1844. https://doi.org/10.1002/cncr.26501

National trends in surgical procedures for hepatocellular carcinoma : 1998-2008. / Nathan, Hari; Segev, Dorry L.; Mayo, Skye; Choti, Michael A.; Cameron, Andrew M.; Wolfgang, Christopher L.; Hirose, Kenzo; Edil, Barish H.; Schulick, Richard D.; Pawlik, Timothy M.

In: Cancer, Vol. 118, No. 7, 01.04.2012, p. 1838-1844.

Research output: Contribution to journalArticle

Nathan, H, Segev, DL, Mayo, S, Choti, MA, Cameron, AM, Wolfgang, CL, Hirose, K, Edil, BH, Schulick, RD & Pawlik, TM 2012, 'National trends in surgical procedures for hepatocellular carcinoma: 1998-2008', Cancer, vol. 118, no. 7, pp. 1838-1844. https://doi.org/10.1002/cncr.26501
Nathan H, Segev DL, Mayo S, Choti MA, Cameron AM, Wolfgang CL et al. National trends in surgical procedures for hepatocellular carcinoma: 1998-2008. Cancer. 2012 Apr 1;118(7):1838-1844. https://doi.org/10.1002/cncr.26501
Nathan, Hari ; Segev, Dorry L. ; Mayo, Skye ; Choti, Michael A. ; Cameron, Andrew M. ; Wolfgang, Christopher L. ; Hirose, Kenzo ; Edil, Barish H. ; Schulick, Richard D. ; Pawlik, Timothy M. / National trends in surgical procedures for hepatocellular carcinoma : 1998-2008. In: Cancer. 2012 ; Vol. 118, No. 7. pp. 1838-1844.
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abstract = "BACKGROUND: The incidence of hepatocellular carcinoma (HCC) is rising, and the options for surgical therapy of HCC have evolved recently, but use of surgical therapy has not been characterized on a representative, nationwide basis.We quantified trends in use, mortality, and patient and hospital characteristics for 3 surgical therapies for HCC (resection, ablation, and transplantation) in the United States from 1998 to 2008. METHODS: Hospital discharge data from the Nationwide Inpatient Sample were used to quantify procedure-related data for each year. Trends over time were summarized as the average annual percent change (AAPC) and corresponding 95{\%} confidence interval (CI). RESULTS: The number of surgical procedures for HCC increased from 1416 to 6769 (AAPC, 13.5{\%}; 95{\%} CI, 10.2{\%}-16.8{\%}). Volumes increased for all surgical procedures, most notably for ablation (AAPC, 17.3{\%}; 95{\%} CI, 6.6{\%}- 29.2{\%}) and transplantation (AAPC, 20.9{\%}; 95{\%} CI, 14.1{\%}-28.1{\%}). When analyzed as a proportion of total procedures, there were declines in the relative use of major hepatectomy (35{\%} to 16{\%}; AAPC, -7.2{\%}, 95{\%} CI, -8.8{\%} to -5.6{\%}) and wedge resection (37{\%} to 22{\%}; AAPC, -4.8{\%}; 95{\%} CI, -6.2{\%} to -3.4{\%}), while the proportion accounted for by transplantation increased (16{\%} to 35{\%}; AAPC, 4.4{\%}; 95{\%} CI, 0.2{\%}-8.9{\%}). Inpatient mortality decreased for each procedure individually and overall from 7.3{\%} to 4.6{\%} (AAPC, -7.7{\%}; 95{\%} CI, -10.8{\%} to -4.5{\%}), despite increasing age and comorbidity burden. CONCLUSIONS: The use of surgical therapy for HCC has increased dramatically over the last decade, with a relative shift away from liver resection and toward liver transplantation. These therapeutic modalities must be better targeted to make the most appropriate use of limited health care resources.",
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AU - Segev, Dorry L.

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AU - Cameron, Andrew M.

AU - Wolfgang, Christopher L.

AU - Hirose, Kenzo

AU - Edil, Barish H.

AU - Schulick, Richard D.

AU - Pawlik, Timothy M.

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N2 - BACKGROUND: The incidence of hepatocellular carcinoma (HCC) is rising, and the options for surgical therapy of HCC have evolved recently, but use of surgical therapy has not been characterized on a representative, nationwide basis.We quantified trends in use, mortality, and patient and hospital characteristics for 3 surgical therapies for HCC (resection, ablation, and transplantation) in the United States from 1998 to 2008. METHODS: Hospital discharge data from the Nationwide Inpatient Sample were used to quantify procedure-related data for each year. Trends over time were summarized as the average annual percent change (AAPC) and corresponding 95% confidence interval (CI). RESULTS: The number of surgical procedures for HCC increased from 1416 to 6769 (AAPC, 13.5%; 95% CI, 10.2%-16.8%). Volumes increased for all surgical procedures, most notably for ablation (AAPC, 17.3%; 95% CI, 6.6%- 29.2%) and transplantation (AAPC, 20.9%; 95% CI, 14.1%-28.1%). When analyzed as a proportion of total procedures, there were declines in the relative use of major hepatectomy (35% to 16%; AAPC, -7.2%, 95% CI, -8.8% to -5.6%) and wedge resection (37% to 22%; AAPC, -4.8%; 95% CI, -6.2% to -3.4%), while the proportion accounted for by transplantation increased (16% to 35%; AAPC, 4.4%; 95% CI, 0.2%-8.9%). Inpatient mortality decreased for each procedure individually and overall from 7.3% to 4.6% (AAPC, -7.7%; 95% CI, -10.8% to -4.5%), despite increasing age and comorbidity burden. CONCLUSIONS: The use of surgical therapy for HCC has increased dramatically over the last decade, with a relative shift away from liver resection and toward liver transplantation. These therapeutic modalities must be better targeted to make the most appropriate use of limited health care resources.

AB - BACKGROUND: The incidence of hepatocellular carcinoma (HCC) is rising, and the options for surgical therapy of HCC have evolved recently, but use of surgical therapy has not been characterized on a representative, nationwide basis.We quantified trends in use, mortality, and patient and hospital characteristics for 3 surgical therapies for HCC (resection, ablation, and transplantation) in the United States from 1998 to 2008. METHODS: Hospital discharge data from the Nationwide Inpatient Sample were used to quantify procedure-related data for each year. Trends over time were summarized as the average annual percent change (AAPC) and corresponding 95% confidence interval (CI). RESULTS: The number of surgical procedures for HCC increased from 1416 to 6769 (AAPC, 13.5%; 95% CI, 10.2%-16.8%). Volumes increased for all surgical procedures, most notably for ablation (AAPC, 17.3%; 95% CI, 6.6%- 29.2%) and transplantation (AAPC, 20.9%; 95% CI, 14.1%-28.1%). When analyzed as a proportion of total procedures, there were declines in the relative use of major hepatectomy (35% to 16%; AAPC, -7.2%, 95% CI, -8.8% to -5.6%) and wedge resection (37% to 22%; AAPC, -4.8%; 95% CI, -6.2% to -3.4%), while the proportion accounted for by transplantation increased (16% to 35%; AAPC, 4.4%; 95% CI, 0.2%-8.9%). Inpatient mortality decreased for each procedure individually and overall from 7.3% to 4.6% (AAPC, -7.7%; 95% CI, -10.8% to -4.5%), despite increasing age and comorbidity burden. CONCLUSIONS: The use of surgical therapy for HCC has increased dramatically over the last decade, with a relative shift away from liver resection and toward liver transplantation. These therapeutic modalities must be better targeted to make the most appropriate use of limited health care resources.

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KW - Liver ablation

KW - Liver resection

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KW - Surgery

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