Nasal administration of the nitric oxide synthase inhibitor L-NAME induces daytime somnolence

Jeffrey M. Sippel, George Giraud, William E. Holden

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    In preliminary studies, human subjects complained of drowsiness after aerosolization of NG-nitro-L-arginine methyl ester (L-NAME) into the nasal passages. We compared the effects of a nasal aerosol of L-NAME (0.5 M, 4 ml) to those of saline on sleep onset latency and exhaled nasal nitric oxide (NO). L-NAME decreased sleep onset latency and exhaled nasal NO. Vasoconstriction and local effects of L-NAME on NO synthesis are unlikely to explain this effect since oxymetazoline, a vasoconstrictor, decreased exhaled NO but had no effect on sleep onset latency. We conclude that aerosolization of L-NAME to the nasal passages induces daytime sleepiness.

    Original languageEnglish (US)
    Pages (from-to)786-788
    Number of pages3
    JournalSleep
    Volume22
    Issue number6
    StatePublished - Sep 15 1999

    Fingerprint

    Intranasal Administration
    NG-Nitroarginine Methyl Ester
    Nitric Oxide Synthase
    Nose
    Nitric Oxide
    Sleep
    Oxymetazoline
    Nasal Sprays
    Sleep Stages
    Vasoconstrictor Agents
    Vasoconstriction

    Keywords

    • L-name
    • Multiple sleep latency test
    • Nasal
    • NG-nitro-l-arginine methyl ester
    • Nitric oxide
    • Nose
    • Sleep

    ASJC Scopus subject areas

    • Physiology

    Cite this

    Nasal administration of the nitric oxide synthase inhibitor L-NAME induces daytime somnolence. / Sippel, Jeffrey M.; Giraud, George; Holden, William E.

    In: Sleep, Vol. 22, No. 6, 15.09.1999, p. 786-788.

    Research output: Contribution to journalArticle

    Sippel, Jeffrey M. ; Giraud, George ; Holden, William E. / Nasal administration of the nitric oxide synthase inhibitor L-NAME induces daytime somnolence. In: Sleep. 1999 ; Vol. 22, No. 6. pp. 786-788.
    @article{bd680ca2aeea4f5c97f7e14f3ca1ac0e,
    title = "Nasal administration of the nitric oxide synthase inhibitor L-NAME induces daytime somnolence",
    abstract = "In preliminary studies, human subjects complained of drowsiness after aerosolization of NG-nitro-L-arginine methyl ester (L-NAME) into the nasal passages. We compared the effects of a nasal aerosol of L-NAME (0.5 M, 4 ml) to those of saline on sleep onset latency and exhaled nasal nitric oxide (NO). L-NAME decreased sleep onset latency and exhaled nasal NO. Vasoconstriction and local effects of L-NAME on NO synthesis are unlikely to explain this effect since oxymetazoline, a vasoconstrictor, decreased exhaled NO but had no effect on sleep onset latency. We conclude that aerosolization of L-NAME to the nasal passages induces daytime sleepiness.",
    keywords = "L-name, Multiple sleep latency test, Nasal, NG-nitro-l-arginine methyl ester, Nitric oxide, Nose, Sleep",
    author = "Sippel, {Jeffrey M.} and George Giraud and Holden, {William E.}",
    year = "1999",
    month = "9",
    day = "15",
    language = "English (US)",
    volume = "22",
    pages = "786--788",
    journal = "Sleep",
    issn = "0161-8105",
    publisher = "American Academy of Sleep Medicine",
    number = "6",

    }

    TY - JOUR

    T1 - Nasal administration of the nitric oxide synthase inhibitor L-NAME induces daytime somnolence

    AU - Sippel, Jeffrey M.

    AU - Giraud, George

    AU - Holden, William E.

    PY - 1999/9/15

    Y1 - 1999/9/15

    N2 - In preliminary studies, human subjects complained of drowsiness after aerosolization of NG-nitro-L-arginine methyl ester (L-NAME) into the nasal passages. We compared the effects of a nasal aerosol of L-NAME (0.5 M, 4 ml) to those of saline on sleep onset latency and exhaled nasal nitric oxide (NO). L-NAME decreased sleep onset latency and exhaled nasal NO. Vasoconstriction and local effects of L-NAME on NO synthesis are unlikely to explain this effect since oxymetazoline, a vasoconstrictor, decreased exhaled NO but had no effect on sleep onset latency. We conclude that aerosolization of L-NAME to the nasal passages induces daytime sleepiness.

    AB - In preliminary studies, human subjects complained of drowsiness after aerosolization of NG-nitro-L-arginine methyl ester (L-NAME) into the nasal passages. We compared the effects of a nasal aerosol of L-NAME (0.5 M, 4 ml) to those of saline on sleep onset latency and exhaled nasal nitric oxide (NO). L-NAME decreased sleep onset latency and exhaled nasal NO. Vasoconstriction and local effects of L-NAME on NO synthesis are unlikely to explain this effect since oxymetazoline, a vasoconstrictor, decreased exhaled NO but had no effect on sleep onset latency. We conclude that aerosolization of L-NAME to the nasal passages induces daytime sleepiness.

    KW - L-name

    KW - Multiple sleep latency test

    KW - Nasal

    KW - NG-nitro-l-arginine methyl ester

    KW - Nitric oxide

    KW - Nose

    KW - Sleep

    UR - http://www.scopus.com/inward/record.url?scp=0033568478&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0033568478&partnerID=8YFLogxK

    M3 - Article

    C2 - 10505824

    AN - SCOPUS:0033568478

    VL - 22

    SP - 786

    EP - 788

    JO - Sleep

    JF - Sleep

    SN - 0161-8105

    IS - 6

    ER -