Abstract
In preliminary studies, human subjects complained of drowsiness after aerosolization of NG-nitro-L-arginine methyl ester (L-NAME) into the nasal passages. We compared the effects of a nasal aerosol of L-NAME (0.5 M, 4 ml) to those of saline on sleep onset latency and exhaled nasal nitric oxide (NO). L-NAME decreased sleep onset latency and exhaled nasal NO. Vasoconstriction and local effects of L-NAME on NO synthesis are unlikely to explain this effect since oxymetazoline, a vasoconstrictor, decreased exhaled NO but had no effect on sleep onset latency. We conclude that aerosolization of L-NAME to the nasal passages induces daytime sleepiness.
Original language | English (US) |
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Pages (from-to) | 786-788 |
Number of pages | 3 |
Journal | Sleep |
Volume | 22 |
Issue number | 6 |
DOIs | |
State | Published - Sep 15 1999 |
Keywords
- L-name
- Multiple sleep latency test
- NG-nitro-l-arginine methyl ester
- Nasal
- Nitric oxide
- Nose
- Sleep
ASJC Scopus subject areas
- Clinical Neurology
- Physiology (medical)