Nasal administration of the nitric oxide synthase inhibitor L-NAME induces daytime somnolence

Jeffrey M. Sippel, George D. Giraud, William E. Holden

    Research output: Contribution to journalArticle

    15 Scopus citations

    Abstract

    In preliminary studies, human subjects complained of drowsiness after aerosolization of NG-nitro-L-arginine methyl ester (L-NAME) into the nasal passages. We compared the effects of a nasal aerosol of L-NAME (0.5 M, 4 ml) to those of saline on sleep onset latency and exhaled nasal nitric oxide (NO). L-NAME decreased sleep onset latency and exhaled nasal NO. Vasoconstriction and local effects of L-NAME on NO synthesis are unlikely to explain this effect since oxymetazoline, a vasoconstrictor, decreased exhaled NO but had no effect on sleep onset latency. We conclude that aerosolization of L-NAME to the nasal passages induces daytime sleepiness.

    Original languageEnglish (US)
    Pages (from-to)786-788
    Number of pages3
    JournalSleep
    Volume22
    Issue number6
    DOIs
    StatePublished - Sep 15 1999

    Keywords

    • L-name
    • Multiple sleep latency test
    • NG-nitro-l-arginine methyl ester
    • Nasal
    • Nitric oxide
    • Nose
    • Sleep

    ASJC Scopus subject areas

    • Clinical Neurology
    • Physiology (medical)

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