n-3 Fatty acids and serum lipoproteins: Animal studies

William Harris

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

This review examines the effects of n-3 fatty acids on serum lipid and lipoprotein concentrations in seven species of experimental animals. n-3 Fatty acids consistently lower serum triacylglycerol concentrations in humans but not in most animals. In addition, a common effect of n-3 fatty acids in animals is a marked reduction in high-density-lipoprotein- cholesterol concentrations, a response virtually never seen with fish-oil supplementation in humans. These differences between animals and humans arise not only from underlying species differences in lipoprotein metabolism but also from differences in experimental designs, the most notable of which is the tendency to feed animals much larger amounts of n-3 fatty acids than supplements provide for humans. Thus, great care must be taken not only to use appropriate animal models when studying lipoprotein metabolism but also to feed the animals comparable amounts of n-3 fatty acids. Failure to properly address these issues will make it difficult to uncover the biochemical basis for the hypolipidemic effect of fish oils in humans through use of experimental animals.

Original languageEnglish (US)
JournalAmerican Journal of Clinical Nutrition
Volume65
Issue number5 SUPPL.
StatePublished - May 1997
Externally publishedYes

Fingerprint

Omega-3 Fatty Acids
lipoproteins
omega-3 fatty acids
Lipoproteins
Serum
Fish Oils
animals
fish oils
laboratory animals
metabolism
interspecific variation
high density lipoprotein cholesterol
blood lipids
HDL Cholesterol
Triglycerides
Research Design
Animal Models
animal models
experimental design
triacylglycerols

Keywords

  • animal studies
  • cholesterol
  • docosahexaenoic acid
  • Eicosapentaenoic acid
  • fish oil
  • high-density lipoproteins
  • low-density lipoproteins
  • n-3 fatty acid
  • triacylglycerol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

n-3 Fatty acids and serum lipoproteins : Animal studies. / Harris, William.

In: American Journal of Clinical Nutrition, Vol. 65, No. 5 SUPPL., 05.1997.

Research output: Contribution to journalArticle

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