Myxopapillary ependymoma: Results of nucleolar organizing region staining

Donald (Don) Ross, P. E. McKeever, H. M. Sandler, K. M. Muraszko

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background. Although myxopapillary ependymomas are generally benign with a tendency for slow growth and local recurrence, they are capable of spread within the nervous system and of extraneural metastasis. Histologic features have not been helpful in determining which patients are at risk for recurrence or dissemination, making management decisions difficult. Methods. A retrospective review was conducted of 14 cases of myxopapillary ependymoma. The nucleolar organizing region (NOR) staining method was used to determine if this technique was useful in the management of these tumors. Results. Five patients had total resections of encapsulated lesions, four had total resections of adherent tumors, and four had subtotal resections. Twelve received postoperative radiation therapy. With a mean follow-up of 80 months, 12 patients are well and disease-free. Two patients have had recurrences after surgery and irradiation, leading to death in one and disability in the other. The mean number of NOR per cell in eight specimens ranged from 0.4- 1.64. The patient who died with intracranial spread had the highest number of NOR per cell. Conclusions. Based on these data and a review of the literature, it is recommended that radiation be delayed until recurrence in tumors that have been totally resected. Local radiation therapy may be indicated in subtotally resected tumors. NOR staining shows promise in predicting the likelihood of spread of tumor. Patients with myxopapillary ependymomas should be followed indefinitely because of the potential for late recurrence, even after aggressive therapy.

Original languageEnglish (US)
Pages (from-to)3114-3118
Number of pages5
JournalCancer
Volume71
Issue number10
StatePublished - 1993
Externally publishedYes

Fingerprint

Ependymoma
Staining and Labeling
Recurrence
Neoplasms
Radiotherapy
Nervous System
Decision Making
Radiation
Neoplasm Metastasis
Growth

Keywords

  • cauda equina
  • ependymoma
  • myxopapillary
  • radiation
  • surgery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ross, D. D., McKeever, P. E., Sandler, H. M., & Muraszko, K. M. (1993). Myxopapillary ependymoma: Results of nucleolar organizing region staining. Cancer, 71(10), 3114-3118.

Myxopapillary ependymoma : Results of nucleolar organizing region staining. / Ross, Donald (Don); McKeever, P. E.; Sandler, H. M.; Muraszko, K. M.

In: Cancer, Vol. 71, No. 10, 1993, p. 3114-3118.

Research output: Contribution to journalArticle

Ross, DD, McKeever, PE, Sandler, HM & Muraszko, KM 1993, 'Myxopapillary ependymoma: Results of nucleolar organizing region staining', Cancer, vol. 71, no. 10, pp. 3114-3118.
Ross DD, McKeever PE, Sandler HM, Muraszko KM. Myxopapillary ependymoma: Results of nucleolar organizing region staining. Cancer. 1993;71(10):3114-3118.
Ross, Donald (Don) ; McKeever, P. E. ; Sandler, H. M. ; Muraszko, K. M. / Myxopapillary ependymoma : Results of nucleolar organizing region staining. In: Cancer. 1993 ; Vol. 71, No. 10. pp. 3114-3118.
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abstract = "Background. Although myxopapillary ependymomas are generally benign with a tendency for slow growth and local recurrence, they are capable of spread within the nervous system and of extraneural metastasis. Histologic features have not been helpful in determining which patients are at risk for recurrence or dissemination, making management decisions difficult. Methods. A retrospective review was conducted of 14 cases of myxopapillary ependymoma. The nucleolar organizing region (NOR) staining method was used to determine if this technique was useful in the management of these tumors. Results. Five patients had total resections of encapsulated lesions, four had total resections of adherent tumors, and four had subtotal resections. Twelve received postoperative radiation therapy. With a mean follow-up of 80 months, 12 patients are well and disease-free. Two patients have had recurrences after surgery and irradiation, leading to death in one and disability in the other. The mean number of NOR per cell in eight specimens ranged from 0.4- 1.64. The patient who died with intracranial spread had the highest number of NOR per cell. Conclusions. Based on these data and a review of the literature, it is recommended that radiation be delayed until recurrence in tumors that have been totally resected. Local radiation therapy may be indicated in subtotally resected tumors. NOR staining shows promise in predicting the likelihood of spread of tumor. Patients with myxopapillary ependymomas should be followed indefinitely because of the potential for late recurrence, even after aggressive therapy.",
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