Myxoinflammatory fibroblastic sarcoma with complex supernumerary ring chromosomes composed of chromosome 3 segments

Atiya Mansoor, Nisreen Fidda, Eleanor Himoe, Misty Payne, Helen Lawce, R. Ellen Magenis

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Myxoinflammatory fibroblastic sarcoma is a rare, recently described, and distinctive low-grade tumor of soft tissue. To our knowledge, there is only one previous report on the cytogenetics of this tumor. That case showed complex structural abnormalities, including a reciprocal translocation between chromosomes 1 and 10 [t(1;10)(p22;q24)] with loss of chromosomes 3 and 13. We describe here a second case showing supernumerary ring chromosomes, and a derivative chromosome 13, with additional material on the short arm. We conclude that the presence of chromosomal abnormalities supports the neoplastic nature of this tumor and aids in its diagnosis. Furthermore, we also postulate that the finding of ring chromosomes, which have been identified in other low-grade soft-tissue tumors, may have important prognostic implications regarding the aggressiveness of this neoplasm.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume152
Issue number1
DOIs
StatePublished - Jul 1 2004

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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