Myosin I and adaptation of mechanical transduction by the inner ear

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Twenty years ago, the description of hair-cell stereocilia as actin-rich structures led to speculation that myosin molecules participated in mechanical transduction in the inner ear. In 1987, Howard and Hudspeth proposed specifically that a myosin I might mediate adaptation of the transduction current carried by hair cells, the sensory cells of the ear. We exploited the myosin literature to design tests of this hypothesis and to show that the responsible isoform is myosin 1c. The identification of this myosin as the adaptation motor would have been impossible without thorough experimentation on other myosins, particularly muscle myosins. The sliding-filament hypothesis for muscle contraction has thus led to a detailed understanding of the behaviour of hair cells.

Original languageEnglish (US)
Pages (from-to)1945-1951
Number of pages7
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume359
Issue number1452
DOIs
StatePublished - Dec 29 2004

Fingerprint

Myosin Type I
Inner Ear
Myosins
myosin
hair
ears
muscle
hairs
contraction
sliding
Muscle
Cells
Stereocilia
cells
Muscle Contraction
muscle contraction
Ear
Actins
Protein Isoforms
actin

Keywords

  • Adaptation
  • Chemical genetics
  • Hair cells
  • Mechanotransduction
  • Myosin

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Myosin I and adaptation of mechanical transduction by the inner ear. / Barr-Gillespie, Peter.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 359, No. 1452, 29.12.2004, p. 1945-1951.

Research output: Contribution to journalArticle

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