TY - JOUR
T1 - Myopericarditis in a pregnant woman with acute promyelocytic leukemia
AU - Oehler, Andrew
AU - Shah, Shimoli
N1 - Publisher Copyright:
© 2014 Japanese College of Cardiology.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Acute promyelocytic leukemia (APL) is a form of acute leukemia with a characteristic translocation, t(15;17), and is considered a hematologic emergency, typically treated with all-trans retinoic acid and an anthracycline. We present the case of a young, gravid woman who was diagnosed with APL in the third trimester, initiated typical treatment, and suffered uncommon cardiac complications.<. Learning objective: Myopericarditis is not a side effect often encountered in the management of acute promyelocytic leukemia with alpha t-retinoic acid, and its mechanism is incompletely understood but possibly related to the differentiation syndrome. This complication can be effectively treated with systemic glucocorticoids, supportive care, and withdrawal of the offending agent, even in the pregnant population>.
AB - Acute promyelocytic leukemia (APL) is a form of acute leukemia with a characteristic translocation, t(15;17), and is considered a hematologic emergency, typically treated with all-trans retinoic acid and an anthracycline. We present the case of a young, gravid woman who was diagnosed with APL in the third trimester, initiated typical treatment, and suffered uncommon cardiac complications.<. Learning objective: Myopericarditis is not a side effect often encountered in the management of acute promyelocytic leukemia with alpha t-retinoic acid, and its mechanism is incompletely understood but possibly related to the differentiation syndrome. This complication can be effectively treated with systemic glucocorticoids, supportive care, and withdrawal of the offending agent, even in the pregnant population>.
KW - Acute promyelocytic leukemia
KW - Differentiation syndrome
KW - Myopericarditis
KW - Pregnancy
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U2 - 10.1016/j.jccase.2014.07.010
DO - 10.1016/j.jccase.2014.07.010
M3 - Article
AN - SCOPUS:84908702907
VL - 10
SP - 200
EP - 203
JO - Journal of Cardiology Cases
JF - Journal of Cardiology Cases
SN - 1878-5409
IS - 5
ER -