Myopericarditis in a pregnant woman with acute promyelocytic leukemia

Andrew Oehler; Shimoli Shah

doi:10.1016/j.jccase.2014.07.010

Myopericarditis in a pregnant woman with acute promyelocytic leukemia

Andrew Oehler, Shimoli Shah

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Acute promyelocytic leukemia (APL) is a form of acute leukemia with a characteristic translocation, t(15;17), and is considered a hematologic emergency, typically treated with all-trans retinoic acid and an anthracycline. We present the case of a young, gravid woman who was diagnosed with APL in the third trimester, initiated typical treatment, and suffered uncommon cardiac complications.<. Learning objective: Myopericarditis is not a side effect often encountered in the management of acute promyelocytic leukemia with alpha t-retinoic acid, and its mechanism is incompletely understood but possibly related to the differentiation syndrome. This complication can be effectively treated with systemic glucocorticoids, supportive care, and withdrawal of the offending agent, even in the pregnant population>.

Original language	English (US)
Pages (from-to)	200-203
Number of pages	4
Journal	Journal of Cardiology Cases
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/j.jccase.2014.07.010
State	Published - Nov 1 2014
Externally published	Yes

Keywords

Acute promyelocytic leukemia
Differentiation syndrome
Myopericarditis
Pregnancy

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jccase.2014.07.010

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title = "Myopericarditis in a pregnant woman with acute promyelocytic leukemia",

abstract = "Acute promyelocytic leukemia (APL) is a form of acute leukemia with a characteristic translocation, t(15;17), and is considered a hematologic emergency, typically treated with all-trans retinoic acid and an anthracycline. We present the case of a young, gravid woman who was diagnosed with APL in the third trimester, initiated typical treatment, and suffered uncommon cardiac complications.<. Learning objective: Myopericarditis is not a side effect often encountered in the management of acute promyelocytic leukemia with alpha t-retinoic acid, and its mechanism is incompletely understood but possibly related to the differentiation syndrome. This complication can be effectively treated with systemic glucocorticoids, supportive care, and withdrawal of the offending agent, even in the pregnant population>.",

keywords = "Acute promyelocytic leukemia, Differentiation syndrome, Myopericarditis, Pregnancy",

author = "Andrew Oehler and Shimoli Shah",

note = "Publisher Copyright: {\textcopyright} 2014 Japanese College of Cardiology.",

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doi = "10.1016/j.jccase.2014.07.010",

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journal = "Journal of Cardiology Cases",

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T1 - Myopericarditis in a pregnant woman with acute promyelocytic leukemia

AU - Oehler, Andrew

AU - Shah, Shimoli

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Acute promyelocytic leukemia (APL) is a form of acute leukemia with a characteristic translocation, t(15;17), and is considered a hematologic emergency, typically treated with all-trans retinoic acid and an anthracycline. We present the case of a young, gravid woman who was diagnosed with APL in the third trimester, initiated typical treatment, and suffered uncommon cardiac complications.<. Learning objective: Myopericarditis is not a side effect often encountered in the management of acute promyelocytic leukemia with alpha t-retinoic acid, and its mechanism is incompletely understood but possibly related to the differentiation syndrome. This complication can be effectively treated with systemic glucocorticoids, supportive care, and withdrawal of the offending agent, even in the pregnant population>.

AB - Acute promyelocytic leukemia (APL) is a form of acute leukemia with a characteristic translocation, t(15;17), and is considered a hematologic emergency, typically treated with all-trans retinoic acid and an anthracycline. We present the case of a young, gravid woman who was diagnosed with APL in the third trimester, initiated typical treatment, and suffered uncommon cardiac complications.<. Learning objective: Myopericarditis is not a side effect often encountered in the management of acute promyelocytic leukemia with alpha t-retinoic acid, and its mechanism is incompletely understood but possibly related to the differentiation syndrome. This complication can be effectively treated with systemic glucocorticoids, supportive care, and withdrawal of the offending agent, even in the pregnant population>.

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KW - Differentiation syndrome

KW - Myopericarditis

KW - Pregnancy

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Myopericarditis in a pregnant woman with acute promyelocytic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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