Myopericarditis in a pregnant woman with acute promyelocytic leukemia

Andrew Oehler, Shimoli Shah

    Research output: Contribution to journalArticle

    1 Scopus citations

    Abstract

    Acute promyelocytic leukemia (APL) is a form of acute leukemia with a characteristic translocation, t(15;17), and is considered a hematologic emergency, typically treated with all-trans retinoic acid and an anthracycline. We present the case of a young, gravid woman who was diagnosed with APL in the third trimester, initiated typical treatment, and suffered uncommon cardiac complications.<. Learning objective: Myopericarditis is not a side effect often encountered in the management of acute promyelocytic leukemia with alpha t-retinoic acid, and its mechanism is incompletely understood but possibly related to the differentiation syndrome. This complication can be effectively treated with systemic glucocorticoids, supportive care, and withdrawal of the offending agent, even in the pregnant population>.

    Original languageEnglish (US)
    Pages (from-to)200-203
    Number of pages4
    JournalJournal of Cardiology Cases
    Volume10
    Issue number5
    DOIs
    StatePublished - Nov 1 2014

    Keywords

    • Acute promyelocytic leukemia
    • Differentiation syndrome
    • Myopericarditis
    • Pregnancy

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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