Myometrial activation and preterm labour

Evidence supporting a role for the prostaglandin F receptor - A review

David M. Olson, D. B. Zaragoza, M. C. Shallow, J. L. Cook, B. F. Mitchell, Peta Grigsby, J. Hirst

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

An increase in the myometrial expression of the prostaglandin (PG) receptors, and especially the PGF receptor (FP), may be an important component of the process initiating preterm labour. In this review of the literature and presentation of new possibilities, evidence will be discussed that demonstrates an increase in mouse uterine FP mRNA occurs at preterm birth whereas uterine PGF concentrations do not increase, suggesting elevated uterine receptor expression and sensitivity is a mechanism for preterm labour initiation. The first examination of the complete human myometrial FP promoter will be described and evidence presented that demonstrates the pro-inflammatory cytokine, interleukin-1β, stimulates FP mRNA expression. Finally new data showing that administration of a specific FP antagonist delays preterm birth in sheep will be presented.

Original languageEnglish (US)
JournalPlacenta
Volume24
Issue numberSUPPL. A
DOIs
StatePublished - Apr 2003
Externally publishedYes

Fingerprint

Prostaglandin Receptors
Dinoprost
Premature Obstetric Labor
Premature Birth
Prostaglandins F
Messenger RNA
Interleukin-1
Sheep
Cytokines
prostaglandin F2alpha receptor

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Olson, D. M., Zaragoza, D. B., Shallow, M. C., Cook, J. L., Mitchell, B. F., Grigsby, P., & Hirst, J. (2003). Myometrial activation and preterm labour: Evidence supporting a role for the prostaglandin F receptor - A review. Placenta, 24(SUPPL. A). https://doi.org/10.1053/plac.2002.0938

Myometrial activation and preterm labour : Evidence supporting a role for the prostaglandin F receptor - A review. / Olson, David M.; Zaragoza, D. B.; Shallow, M. C.; Cook, J. L.; Mitchell, B. F.; Grigsby, Peta; Hirst, J.

In: Placenta, Vol. 24, No. SUPPL. A, 04.2003.

Research output: Contribution to journalArticle

Olson, DM, Zaragoza, DB, Shallow, MC, Cook, JL, Mitchell, BF, Grigsby, P & Hirst, J 2003, 'Myometrial activation and preterm labour: Evidence supporting a role for the prostaglandin F receptor - A review', Placenta, vol. 24, no. SUPPL. A. https://doi.org/10.1053/plac.2002.0938
Olson, David M. ; Zaragoza, D. B. ; Shallow, M. C. ; Cook, J. L. ; Mitchell, B. F. ; Grigsby, Peta ; Hirst, J. / Myometrial activation and preterm labour : Evidence supporting a role for the prostaglandin F receptor - A review. In: Placenta. 2003 ; Vol. 24, No. SUPPL. A.
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