Myocardial viability by echocardiography predicts long-term survival after revascularisation in patients with heart failure due to ischaemic cardiomyopathy

R. Senior, Sanjiv Kaul, A. Lahiri

Research output: Contribution to journalArticle

Abstract

Revascularisation (Rev) improves survival in coronary artery disease (CAD) patients with angina and left ventricular (LV) systolic dysfunction however, there is insufficient long term data regarding survival benefit of Rev in patients with predominant symptoms of heart failure (HF). Follow-up was obtained in 87 consecutive patients with HF due to ischaemic LV systolic dysfunction (NYHA Class II-IV; LVEF: 0.25±0.09) who were investigated with low dose dobutamine echocardiography (DE) Myocardial viability (MV) within each of the 12 myocardial segments representing the LV was defined as having either normal function or mild dysynergy at rest or severe resting dysynergy that improved or worsened on DE. Thirty seven patients underwent revascularisation based on clinical grounds. At a mean follow up of 40±17 months there were 22 (25%) cardiac related deaths. Multivariate analysis using clinical data (age, sex, history of infarction, angina, hypertension, diabetes mellitus and hyperlipedermia), drug therapy, LVEF, number of diseased coronary arteries and number of viable segments, revealed that patients with ≥5 segments with MV who underwent Rev was the only independent predictor of survival; hazard ratio (95% Cl): 0.39 (0.17-0.91), p=0.01. Patients with

Original languageEnglish (US)
JournalHeart
Volume81
Issue numberSUPPL. 1
StatePublished - May 1999
Externally publishedYes

Fingerprint

Cardiomyopathies
Echocardiography
Heart Failure
Survival
Dobutamine
Left Ventricular Dysfunction
Coronary Artery Disease
Infarction
Diabetes Mellitus
Multivariate Analysis
Hypertension
Drug Therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{bd24d92c2124468cbde7a9dd7f271c6e,
title = "Myocardial viability by echocardiography predicts long-term survival after revascularisation in patients with heart failure due to ischaemic cardiomyopathy",
abstract = "Revascularisation (Rev) improves survival in coronary artery disease (CAD) patients with angina and left ventricular (LV) systolic dysfunction however, there is insufficient long term data regarding survival benefit of Rev in patients with predominant symptoms of heart failure (HF). Follow-up was obtained in 87 consecutive patients with HF due to ischaemic LV systolic dysfunction (NYHA Class II-IV; LVEF: 0.25±0.09) who were investigated with low dose dobutamine echocardiography (DE) Myocardial viability (MV) within each of the 12 myocardial segments representing the LV was defined as having either normal function or mild dysynergy at rest or severe resting dysynergy that improved or worsened on DE. Thirty seven patients underwent revascularisation based on clinical grounds. At a mean follow up of 40±17 months there were 22 (25{\%}) cardiac related deaths. Multivariate analysis using clinical data (age, sex, history of infarction, angina, hypertension, diabetes mellitus and hyperlipedermia), drug therapy, LVEF, number of diseased coronary arteries and number of viable segments, revealed that patients with ≥5 segments with MV who underwent Rev was the only independent predictor of survival; hazard ratio (95{\%} Cl): 0.39 (0.17-0.91), p=0.01. Patients with",
author = "R. Senior and Sanjiv Kaul and A. Lahiri",
year = "1999",
month = "5",
language = "English (US)",
volume = "81",
journal = "Heart",
issn = "1355-6037",
publisher = "BMJ Publishing Group",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Myocardial viability by echocardiography predicts long-term survival after revascularisation in patients with heart failure due to ischaemic cardiomyopathy

AU - Senior, R.

AU - Kaul, Sanjiv

AU - Lahiri, A.

PY - 1999/5

Y1 - 1999/5

N2 - Revascularisation (Rev) improves survival in coronary artery disease (CAD) patients with angina and left ventricular (LV) systolic dysfunction however, there is insufficient long term data regarding survival benefit of Rev in patients with predominant symptoms of heart failure (HF). Follow-up was obtained in 87 consecutive patients with HF due to ischaemic LV systolic dysfunction (NYHA Class II-IV; LVEF: 0.25±0.09) who were investigated with low dose dobutamine echocardiography (DE) Myocardial viability (MV) within each of the 12 myocardial segments representing the LV was defined as having either normal function or mild dysynergy at rest or severe resting dysynergy that improved or worsened on DE. Thirty seven patients underwent revascularisation based on clinical grounds. At a mean follow up of 40±17 months there were 22 (25%) cardiac related deaths. Multivariate analysis using clinical data (age, sex, history of infarction, angina, hypertension, diabetes mellitus and hyperlipedermia), drug therapy, LVEF, number of diseased coronary arteries and number of viable segments, revealed that patients with ≥5 segments with MV who underwent Rev was the only independent predictor of survival; hazard ratio (95% Cl): 0.39 (0.17-0.91), p=0.01. Patients with

AB - Revascularisation (Rev) improves survival in coronary artery disease (CAD) patients with angina and left ventricular (LV) systolic dysfunction however, there is insufficient long term data regarding survival benefit of Rev in patients with predominant symptoms of heart failure (HF). Follow-up was obtained in 87 consecutive patients with HF due to ischaemic LV systolic dysfunction (NYHA Class II-IV; LVEF: 0.25±0.09) who were investigated with low dose dobutamine echocardiography (DE) Myocardial viability (MV) within each of the 12 myocardial segments representing the LV was defined as having either normal function or mild dysynergy at rest or severe resting dysynergy that improved or worsened on DE. Thirty seven patients underwent revascularisation based on clinical grounds. At a mean follow up of 40±17 months there were 22 (25%) cardiac related deaths. Multivariate analysis using clinical data (age, sex, history of infarction, angina, hypertension, diabetes mellitus and hyperlipedermia), drug therapy, LVEF, number of diseased coronary arteries and number of viable segments, revealed that patients with ≥5 segments with MV who underwent Rev was the only independent predictor of survival; hazard ratio (95% Cl): 0.39 (0.17-0.91), p=0.01. Patients with

UR - http://www.scopus.com/inward/record.url?scp=33750913688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750913688&partnerID=8YFLogxK

M3 - Article

VL - 81

JO - Heart

JF - Heart

SN - 1355-6037

IS - SUPPL. 1

ER -