Mapa T1 e coeficiente de partição do miocárdio em aparelho 3 tesla: Comparação entre gadobenato de dimeglumina e gadofosveset trissódico

Translated title of the contribution: Myocardial T1 mapping and determination of partition coefficients at 3 tesla: Comparison between gadobenate dimeglumine and gadofosveset trisodium

Marcelo Souto Nacif, Fabio S. Raman, Neville Gai, Jacquin Jones, Rob J. Van Der Geest, Christopher Sibley, Songtao Liu, David A. Bluemke

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To compare an albumin-bound gadolinium chelate (gadofosveset trisodium) and an extracellular contrast agent (gado-benate dimeglumine), in terms of their effects on myocardial longitudinal (T1) relaxation time and partition coefficient. Materials and Methods: Study subjects underwent two imaging sessions for T1 mapping at 3 tesla with a modified look-locker inversion recovery (MOLLI) pulse sequence to obtain one pre-contrast T1 map and two post-contrast T1 maps (mean 15 and 21 min, respectively). The partition coefficient was calculated as ΔR1myocardium/ΔR1blood, where R1 is 1/T1. Results: A total of 252 myocardial and blood pool T1 values were obtained in 21 healthy subjects. After gadolinium administration, the myocardial T1 was longer for gadofosveset than for gadobenate, the mean difference between the two contrast agents being −7.6 ± 60 ms (p = 0.41). The inverse was true for the blood pool T1, which was longer for gadobenate than for gadofosveset, the mean difference being 56.5 ± 67 ms (p < 0.001). The partition coefficient (λ) was higher for gadobenate than gadofosveset (0.41 vs. 0.33), indicating slower blood pool washout for gadofosveset than for gadobenate. Conclusion: Myocardial T1 times did not differ significantly between gadobenate and gadofosveset. At typical clinical doses of the contrast agents, partition coefficients were significantly lower for the intravascular contrast agent than for the extravascular agent.

Original languagePortuguese
Pages (from-to)13-19
Number of pages7
JournalRadiologia Brasileira
Volume51
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

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Contrast Media
Gadolinium
Albumins
Healthy Volunteers
gadofosveset trisodium
gadobenic acid

Keywords

  • Contrast media
  • Gadolinium
  • Gadolinium DTPA
  • Magnetic resonance imaging/methods
  • Myocardium/pathology
  • Organometallic compounds

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Mapa T1 e coeficiente de partição do miocárdio em aparelho 3 tesla : Comparação entre gadobenato de dimeglumina e gadofosveset trissódico. / Nacif, Marcelo Souto; Raman, Fabio S.; Gai, Neville; Jones, Jacquin; Van Der Geest, Rob J.; Sibley, Christopher; Liu, Songtao; Bluemke, David A.

In: Radiologia Brasileira, Vol. 51, No. 1, 01.01.2018, p. 13-19.

Research output: Contribution to journalArticle

Nacif, Marcelo Souto ; Raman, Fabio S. ; Gai, Neville ; Jones, Jacquin ; Van Der Geest, Rob J. ; Sibley, Christopher ; Liu, Songtao ; Bluemke, David A. / Mapa T1 e coeficiente de partição do miocárdio em aparelho 3 tesla : Comparação entre gadobenato de dimeglumina e gadofosveset trissódico. In: Radiologia Brasileira. 2018 ; Vol. 51, No. 1. pp. 13-19.
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abstract = "Objective: To compare an albumin-bound gadolinium chelate (gadofosveset trisodium) and an extracellular contrast agent (gado-benate dimeglumine), in terms of their effects on myocardial longitudinal (T1) relaxation time and partition coefficient. Materials and Methods: Study subjects underwent two imaging sessions for T1 mapping at 3 tesla with a modified look-locker inversion recovery (MOLLI) pulse sequence to obtain one pre-contrast T1 map and two post-contrast T1 maps (mean 15 and 21 min, respectively). The partition coefficient was calculated as ΔR1myocardium/ΔR1blood, where R1 is 1/T1. Results: A total of 252 myocardial and blood pool T1 values were obtained in 21 healthy subjects. After gadolinium administration, the myocardial T1 was longer for gadofosveset than for gadobenate, the mean difference between the two contrast agents being −7.6 ± 60 ms (p = 0.41). The inverse was true for the blood pool T1, which was longer for gadobenate than for gadofosveset, the mean difference being 56.5 ± 67 ms (p < 0.001). The partition coefficient (λ) was higher for gadobenate than gadofosveset (0.41 vs. 0.33), indicating slower blood pool washout for gadofosveset than for gadobenate. Conclusion: Myocardial T1 times did not differ significantly between gadobenate and gadofosveset. At typical clinical doses of the contrast agents, partition coefficients were significantly lower for the intravascular contrast agent than for the extravascular agent.",
keywords = "Contrast media, Gadolinium, Gadolinium DTPA, Magnetic resonance imaging/methods, Myocardium/pathology, Organometallic compounds",
author = "Nacif, {Marcelo Souto} and Raman, {Fabio S.} and Neville Gai and Jacquin Jones and {Van Der Geest}, {Rob J.} and Christopher Sibley and Songtao Liu and Bluemke, {David A.}",
year = "2018",
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T1 - Mapa T1 e coeficiente de partição do miocárdio em aparelho 3 tesla

T2 - Comparação entre gadobenato de dimeglumina e gadofosveset trissódico

AU - Nacif, Marcelo Souto

AU - Raman, Fabio S.

AU - Gai, Neville

AU - Jones, Jacquin

AU - Van Der Geest, Rob J.

AU - Sibley, Christopher

AU - Liu, Songtao

AU - Bluemke, David A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: To compare an albumin-bound gadolinium chelate (gadofosveset trisodium) and an extracellular contrast agent (gado-benate dimeglumine), in terms of their effects on myocardial longitudinal (T1) relaxation time and partition coefficient. Materials and Methods: Study subjects underwent two imaging sessions for T1 mapping at 3 tesla with a modified look-locker inversion recovery (MOLLI) pulse sequence to obtain one pre-contrast T1 map and two post-contrast T1 maps (mean 15 and 21 min, respectively). The partition coefficient was calculated as ΔR1myocardium/ΔR1blood, where R1 is 1/T1. Results: A total of 252 myocardial and blood pool T1 values were obtained in 21 healthy subjects. After gadolinium administration, the myocardial T1 was longer for gadofosveset than for gadobenate, the mean difference between the two contrast agents being −7.6 ± 60 ms (p = 0.41). The inverse was true for the blood pool T1, which was longer for gadobenate than for gadofosveset, the mean difference being 56.5 ± 67 ms (p < 0.001). The partition coefficient (λ) was higher for gadobenate than gadofosveset (0.41 vs. 0.33), indicating slower blood pool washout for gadofosveset than for gadobenate. Conclusion: Myocardial T1 times did not differ significantly between gadobenate and gadofosveset. At typical clinical doses of the contrast agents, partition coefficients were significantly lower for the intravascular contrast agent than for the extravascular agent.

AB - Objective: To compare an albumin-bound gadolinium chelate (gadofosveset trisodium) and an extracellular contrast agent (gado-benate dimeglumine), in terms of their effects on myocardial longitudinal (T1) relaxation time and partition coefficient. Materials and Methods: Study subjects underwent two imaging sessions for T1 mapping at 3 tesla with a modified look-locker inversion recovery (MOLLI) pulse sequence to obtain one pre-contrast T1 map and two post-contrast T1 maps (mean 15 and 21 min, respectively). The partition coefficient was calculated as ΔR1myocardium/ΔR1blood, where R1 is 1/T1. Results: A total of 252 myocardial and blood pool T1 values were obtained in 21 healthy subjects. After gadolinium administration, the myocardial T1 was longer for gadofosveset than for gadobenate, the mean difference between the two contrast agents being −7.6 ± 60 ms (p = 0.41). The inverse was true for the blood pool T1, which was longer for gadobenate than for gadofosveset, the mean difference being 56.5 ± 67 ms (p < 0.001). The partition coefficient (λ) was higher for gadobenate than gadofosveset (0.41 vs. 0.33), indicating slower blood pool washout for gadofosveset than for gadobenate. Conclusion: Myocardial T1 times did not differ significantly between gadobenate and gadofosveset. At typical clinical doses of the contrast agents, partition coefficients were significantly lower for the intravascular contrast agent than for the extravascular agent.

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KW - Gadolinium DTPA

KW - Magnetic resonance imaging/methods

KW - Myocardium/pathology

KW - Organometallic compounds

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