Myocardial structural associations with local electrograms

A study of postinfarct ventricular tachycardia pathophysiology and magnetic resonance-based noninvasive mapping

Takeshi Sasaki, Christopher F. Miller, Rozann Hansford, Juemin Yang, Brian S. Caffo, Menekhem M. Zviman, Charles Henrikson, Joseph E. Marine, David Spragg, Alan Cheng, Harikrishna Tandri, Sunil Sinha, Aravindan Kolandaivelu, Stefan L. Zimmerman, David A. Bluemke, Gordon F. Tomaselli, Ronald D. Berger, Hugh Calkins, Henry R. Halperin, Saman Nazarian

    Research output: Contribution to journalArticle

    48 Citations (Scopus)

    Abstract

    Background: The association of scar on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) with local electrograms on electroanatomic mapping has been investigated. We aimed to quantify these associations to gain insights regarding LGE-CMR image characteristics of tissues and critical sites that support postinfarct ventricular tachycardia (VT). Methods and Results: LGE-CMR was performed in 23 patients with ischemic cardiomyopathy before VT ablation. Left ventricular wall thickness and postinfarct scar thickness were measured in each of 20 sectors per LGE-CMR short-axis plane. Electroanatomic mapping points were retrospectively registered to the corresponding LGE-CMR images. Multivariable regression analysis, clustered by patient, revealed significant associations among left ventricular wall thickness, postinfarct scar thickness, and intramural scar location on LGE-CMR, and local endocardial electrogram bipolar/unipolar voltage, duration, and deflections on electroanatomic mapping. Anteroposterior and septal/lateral scar localization was also associated with bipolar and unipolar voltage. Antiarrhythmic drug use was associated with electrogram duration. Critical sites of postinfarct VT were associated with >25% scar transmurality, and slow conduction sites with >40 ms stimulus-QRS time were associated with >75% scar transmurality. Conclusions: Critical sites for maintenance of postinfarct VT are confined to areas with >25% scar transmurality. Our data provide insights into the structural substrates for delayed conduction and VT and may reduce procedural time devoted to substrate mapping, overcome limitations of invasive mapping because of sampling density, and enhance magnetic resonance-based ablation by feature extraction from complex images.

    Original languageEnglish (US)
    Pages (from-to)1081-1090
    Number of pages10
    JournalCirculation: Arrhythmia and Electrophysiology
    Volume5
    Issue number6
    DOIs
    StatePublished - Dec 2012

    Fingerprint

    Ventricular Tachycardia
    Cicatrix
    Gadolinium
    Magnetic Resonance Spectroscopy
    Anti-Arrhythmia Agents
    Cardiomyopathies
    Regression Analysis
    Maintenance

    Keywords

    • Ischemic heart disease
    • Late gadolinium enhancement
    • Magnetic resonance imaging
    • Mapping
    • Ventricular tachycardia

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)

    Cite this

    Myocardial structural associations with local electrograms : A study of postinfarct ventricular tachycardia pathophysiology and magnetic resonance-based noninvasive mapping. / Sasaki, Takeshi; Miller, Christopher F.; Hansford, Rozann; Yang, Juemin; Caffo, Brian S.; Zviman, Menekhem M.; Henrikson, Charles; Marine, Joseph E.; Spragg, David; Cheng, Alan; Tandri, Harikrishna; Sinha, Sunil; Kolandaivelu, Aravindan; Zimmerman, Stefan L.; Bluemke, David A.; Tomaselli, Gordon F.; Berger, Ronald D.; Calkins, Hugh; Halperin, Henry R.; Nazarian, Saman.

    In: Circulation: Arrhythmia and Electrophysiology, Vol. 5, No. 6, 12.2012, p. 1081-1090.

    Research output: Contribution to journalArticle

    Sasaki, T, Miller, CF, Hansford, R, Yang, J, Caffo, BS, Zviman, MM, Henrikson, C, Marine, JE, Spragg, D, Cheng, A, Tandri, H, Sinha, S, Kolandaivelu, A, Zimmerman, SL, Bluemke, DA, Tomaselli, GF, Berger, RD, Calkins, H, Halperin, HR & Nazarian, S 2012, 'Myocardial structural associations with local electrograms: A study of postinfarct ventricular tachycardia pathophysiology and magnetic resonance-based noninvasive mapping', Circulation: Arrhythmia and Electrophysiology, vol. 5, no. 6, pp. 1081-1090. https://doi.org/10.1161/CIRCEP.112.970699
    Sasaki, Takeshi ; Miller, Christopher F. ; Hansford, Rozann ; Yang, Juemin ; Caffo, Brian S. ; Zviman, Menekhem M. ; Henrikson, Charles ; Marine, Joseph E. ; Spragg, David ; Cheng, Alan ; Tandri, Harikrishna ; Sinha, Sunil ; Kolandaivelu, Aravindan ; Zimmerman, Stefan L. ; Bluemke, David A. ; Tomaselli, Gordon F. ; Berger, Ronald D. ; Calkins, Hugh ; Halperin, Henry R. ; Nazarian, Saman. / Myocardial structural associations with local electrograms : A study of postinfarct ventricular tachycardia pathophysiology and magnetic resonance-based noninvasive mapping. In: Circulation: Arrhythmia and Electrophysiology. 2012 ; Vol. 5, No. 6. pp. 1081-1090.
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    title = "Myocardial structural associations with local electrograms: A study of postinfarct ventricular tachycardia pathophysiology and magnetic resonance-based noninvasive mapping",
    abstract = "Background: The association of scar on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) with local electrograms on electroanatomic mapping has been investigated. We aimed to quantify these associations to gain insights regarding LGE-CMR image characteristics of tissues and critical sites that support postinfarct ventricular tachycardia (VT). Methods and Results: LGE-CMR was performed in 23 patients with ischemic cardiomyopathy before VT ablation. Left ventricular wall thickness and postinfarct scar thickness were measured in each of 20 sectors per LGE-CMR short-axis plane. Electroanatomic mapping points were retrospectively registered to the corresponding LGE-CMR images. Multivariable regression analysis, clustered by patient, revealed significant associations among left ventricular wall thickness, postinfarct scar thickness, and intramural scar location on LGE-CMR, and local endocardial electrogram bipolar/unipolar voltage, duration, and deflections on electroanatomic mapping. Anteroposterior and septal/lateral scar localization was also associated with bipolar and unipolar voltage. Antiarrhythmic drug use was associated with electrogram duration. Critical sites of postinfarct VT were associated with >25{\%} scar transmurality, and slow conduction sites with >40 ms stimulus-QRS time were associated with >75{\%} scar transmurality. Conclusions: Critical sites for maintenance of postinfarct VT are confined to areas with >25{\%} scar transmurality. Our data provide insights into the structural substrates for delayed conduction and VT and may reduce procedural time devoted to substrate mapping, overcome limitations of invasive mapping because of sampling density, and enhance magnetic resonance-based ablation by feature extraction from complex images.",
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    T2 - A study of postinfarct ventricular tachycardia pathophysiology and magnetic resonance-based noninvasive mapping

    AU - Sasaki, Takeshi

    AU - Miller, Christopher F.

    AU - Hansford, Rozann

    AU - Yang, Juemin

    AU - Caffo, Brian S.

    AU - Zviman, Menekhem M.

    AU - Henrikson, Charles

    AU - Marine, Joseph E.

    AU - Spragg, David

    AU - Cheng, Alan

    AU - Tandri, Harikrishna

    AU - Sinha, Sunil

    AU - Kolandaivelu, Aravindan

    AU - Zimmerman, Stefan L.

    AU - Bluemke, David A.

    AU - Tomaselli, Gordon F.

    AU - Berger, Ronald D.

    AU - Calkins, Hugh

    AU - Halperin, Henry R.

    AU - Nazarian, Saman

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    N2 - Background: The association of scar on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) with local electrograms on electroanatomic mapping has been investigated. We aimed to quantify these associations to gain insights regarding LGE-CMR image characteristics of tissues and critical sites that support postinfarct ventricular tachycardia (VT). Methods and Results: LGE-CMR was performed in 23 patients with ischemic cardiomyopathy before VT ablation. Left ventricular wall thickness and postinfarct scar thickness were measured in each of 20 sectors per LGE-CMR short-axis plane. Electroanatomic mapping points were retrospectively registered to the corresponding LGE-CMR images. Multivariable regression analysis, clustered by patient, revealed significant associations among left ventricular wall thickness, postinfarct scar thickness, and intramural scar location on LGE-CMR, and local endocardial electrogram bipolar/unipolar voltage, duration, and deflections on electroanatomic mapping. Anteroposterior and septal/lateral scar localization was also associated with bipolar and unipolar voltage. Antiarrhythmic drug use was associated with electrogram duration. Critical sites of postinfarct VT were associated with >25% scar transmurality, and slow conduction sites with >40 ms stimulus-QRS time were associated with >75% scar transmurality. Conclusions: Critical sites for maintenance of postinfarct VT are confined to areas with >25% scar transmurality. Our data provide insights into the structural substrates for delayed conduction and VT and may reduce procedural time devoted to substrate mapping, overcome limitations of invasive mapping because of sampling density, and enhance magnetic resonance-based ablation by feature extraction from complex images.

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    KW - Ischemic heart disease

    KW - Late gadolinium enhancement

    KW - Magnetic resonance imaging

    KW - Mapping

    KW - Ventricular tachycardia

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