Myocardial Strain Rate Is a Superior Method for Evaluation of Left Ventricular Subendocardial Function Compared with Tissue Doppler Imaging

Ikuo Hashimoto, Xiaokui Li, Aarti Hejmadi Bhat, Michael Jones, Arthur D. Zetts, David Sahn

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: This study was performed to evaluate subendocardial function using strain rate imaging (SRI). BACKGROUND: The subendocardium and mid-wall of the left ventricle (LV) play important roles in ventricular function. Previous methods used for evaluating this function are either invasive or cumbersome. Strain rate imaging by ultrasound is a newly developed echocardiographic modality based on tissue Doppler imaging (TDI) that allows quantitative assessment of regional myocardial wall motion. METHODS: We examined eight sheep using TDI in apical four-chamber views to evaluate the LV free wall. Peak strain rates (SRs) during isovolumic relaxation (IR), isovolumic contraction (IC), and myocardial strain were measured in the endocardial (End), mid-myocardial (Mid), and epicardial (Epi) layers. For four hemodynamic conditions (created after baseline by blood, dobutamine, and metoprolol infusion), we compared differences in SR of End, Mid, and Epi layers to peak positive and negative first derivative of LV pressure (dP/dt). RESULTS: Strain rate during IC showed a good correlation with +dP/dt (r = 0.74, p <0.001) and during IR with -dP/dt (r = 0.67, p = 0.0003). There was a significant difference in SR between the myocardial layers during both IC and IR (End: -3.4 ± 2.2 s-1, Mid: -1.8 ± 1.5 s-1 Epi: -0.63 ± 1.0 s-1, p <0.0001 during IC; End: 2.2 ± 1.5 s-1, Mid: 1.0 ± 0.8 s-1, Epi: 0.47 ± 0.64 s-1, p <0.0001 during IR). Also, SRs of the End and Mid layers during IC were significantly altered by different hemodynamic conditions (End at baseline: 1.7 ± 0.7 s-1; blood: 2.0 ± 1.1 s -1; dobutamine: 3.4 ± 2.3 s-1; metoprolol: 1.0 ± 0.4 s-1; p <0.05). Myocardial strain showed differences in each layer (End: -34.3 ± 12.6%; Mid: -22.6 ± 12.1%; Epi: -11.4 ± 7.9%; p <0.0001) and changed significantly in different hemodynamic conditions (p <0.0001). CONCLUSIONS: Strain and SR appear useful and sensitive for evaluating myocardial function, especially for the subendocardial region.

Original languageEnglish (US)
Pages (from-to)1574-1583
Number of pages10
JournalJournal of the American College of Cardiology
Volume42
Issue number9
DOIs
StatePublished - Nov 5 2003

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Left Ventricular Function
Heart Ventricles
Metoprolol
Dobutamine
Hemodynamics
Myocardial Contraction
Ventricular Function
Ultrasonography
Sheep
Pressure

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Myocardial Strain Rate Is a Superior Method for Evaluation of Left Ventricular Subendocardial Function Compared with Tissue Doppler Imaging. / Hashimoto, Ikuo; Li, Xiaokui; Bhat, Aarti Hejmadi; Jones, Michael; Zetts, Arthur D.; Sahn, David.

In: Journal of the American College of Cardiology, Vol. 42, No. 9, 05.11.2003, p. 1574-1583.

Research output: Contribution to journalArticle

Hashimoto, Ikuo ; Li, Xiaokui ; Bhat, Aarti Hejmadi ; Jones, Michael ; Zetts, Arthur D. ; Sahn, David. / Myocardial Strain Rate Is a Superior Method for Evaluation of Left Ventricular Subendocardial Function Compared with Tissue Doppler Imaging. In: Journal of the American College of Cardiology. 2003 ; Vol. 42, No. 9. pp. 1574-1583.
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title = "Myocardial Strain Rate Is a Superior Method for Evaluation of Left Ventricular Subendocardial Function Compared with Tissue Doppler Imaging",
abstract = "OBJECTIVES: This study was performed to evaluate subendocardial function using strain rate imaging (SRI). BACKGROUND: The subendocardium and mid-wall of the left ventricle (LV) play important roles in ventricular function. Previous methods used for evaluating this function are either invasive or cumbersome. Strain rate imaging by ultrasound is a newly developed echocardiographic modality based on tissue Doppler imaging (TDI) that allows quantitative assessment of regional myocardial wall motion. METHODS: We examined eight sheep using TDI in apical four-chamber views to evaluate the LV free wall. Peak strain rates (SRs) during isovolumic relaxation (IR), isovolumic contraction (IC), and myocardial strain were measured in the endocardial (End), mid-myocardial (Mid), and epicardial (Epi) layers. For four hemodynamic conditions (created after baseline by blood, dobutamine, and metoprolol infusion), we compared differences in SR of End, Mid, and Epi layers to peak positive and negative first derivative of LV pressure (dP/dt). RESULTS: Strain rate during IC showed a good correlation with +dP/dt (r = 0.74, p <0.001) and during IR with -dP/dt (r = 0.67, p = 0.0003). There was a significant difference in SR between the myocardial layers during both IC and IR (End: -3.4 ± 2.2 s-1, Mid: -1.8 ± 1.5 s-1 Epi: -0.63 ± 1.0 s-1, p <0.0001 during IC; End: 2.2 ± 1.5 s-1, Mid: 1.0 ± 0.8 s-1, Epi: 0.47 ± 0.64 s-1, p <0.0001 during IR). Also, SRs of the End and Mid layers during IC were significantly altered by different hemodynamic conditions (End at baseline: 1.7 ± 0.7 s-1; blood: 2.0 ± 1.1 s -1; dobutamine: 3.4 ± 2.3 s-1; metoprolol: 1.0 ± 0.4 s-1; p <0.05). Myocardial strain showed differences in each layer (End: -34.3 ± 12.6{\%}; Mid: -22.6 ± 12.1{\%}; Epi: -11.4 ± 7.9{\%}; p <0.0001) and changed significantly in different hemodynamic conditions (p <0.0001). CONCLUSIONS: Strain and SR appear useful and sensitive for evaluating myocardial function, especially for the subendocardial region.",
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T1 - Myocardial Strain Rate Is a Superior Method for Evaluation of Left Ventricular Subendocardial Function Compared with Tissue Doppler Imaging

AU - Hashimoto, Ikuo

AU - Li, Xiaokui

AU - Bhat, Aarti Hejmadi

AU - Jones, Michael

AU - Zetts, Arthur D.

AU - Sahn, David

PY - 2003/11/5

Y1 - 2003/11/5

N2 - OBJECTIVES: This study was performed to evaluate subendocardial function using strain rate imaging (SRI). BACKGROUND: The subendocardium and mid-wall of the left ventricle (LV) play important roles in ventricular function. Previous methods used for evaluating this function are either invasive or cumbersome. Strain rate imaging by ultrasound is a newly developed echocardiographic modality based on tissue Doppler imaging (TDI) that allows quantitative assessment of regional myocardial wall motion. METHODS: We examined eight sheep using TDI in apical four-chamber views to evaluate the LV free wall. Peak strain rates (SRs) during isovolumic relaxation (IR), isovolumic contraction (IC), and myocardial strain were measured in the endocardial (End), mid-myocardial (Mid), and epicardial (Epi) layers. For four hemodynamic conditions (created after baseline by blood, dobutamine, and metoprolol infusion), we compared differences in SR of End, Mid, and Epi layers to peak positive and negative first derivative of LV pressure (dP/dt). RESULTS: Strain rate during IC showed a good correlation with +dP/dt (r = 0.74, p <0.001) and during IR with -dP/dt (r = 0.67, p = 0.0003). There was a significant difference in SR between the myocardial layers during both IC and IR (End: -3.4 ± 2.2 s-1, Mid: -1.8 ± 1.5 s-1 Epi: -0.63 ± 1.0 s-1, p <0.0001 during IC; End: 2.2 ± 1.5 s-1, Mid: 1.0 ± 0.8 s-1, Epi: 0.47 ± 0.64 s-1, p <0.0001 during IR). Also, SRs of the End and Mid layers during IC were significantly altered by different hemodynamic conditions (End at baseline: 1.7 ± 0.7 s-1; blood: 2.0 ± 1.1 s -1; dobutamine: 3.4 ± 2.3 s-1; metoprolol: 1.0 ± 0.4 s-1; p <0.05). Myocardial strain showed differences in each layer (End: -34.3 ± 12.6%; Mid: -22.6 ± 12.1%; Epi: -11.4 ± 7.9%; p <0.0001) and changed significantly in different hemodynamic conditions (p <0.0001). CONCLUSIONS: Strain and SR appear useful and sensitive for evaluating myocardial function, especially for the subendocardial region.

AB - OBJECTIVES: This study was performed to evaluate subendocardial function using strain rate imaging (SRI). BACKGROUND: The subendocardium and mid-wall of the left ventricle (LV) play important roles in ventricular function. Previous methods used for evaluating this function are either invasive or cumbersome. Strain rate imaging by ultrasound is a newly developed echocardiographic modality based on tissue Doppler imaging (TDI) that allows quantitative assessment of regional myocardial wall motion. METHODS: We examined eight sheep using TDI in apical four-chamber views to evaluate the LV free wall. Peak strain rates (SRs) during isovolumic relaxation (IR), isovolumic contraction (IC), and myocardial strain were measured in the endocardial (End), mid-myocardial (Mid), and epicardial (Epi) layers. For four hemodynamic conditions (created after baseline by blood, dobutamine, and metoprolol infusion), we compared differences in SR of End, Mid, and Epi layers to peak positive and negative first derivative of LV pressure (dP/dt). RESULTS: Strain rate during IC showed a good correlation with +dP/dt (r = 0.74, p <0.001) and during IR with -dP/dt (r = 0.67, p = 0.0003). There was a significant difference in SR between the myocardial layers during both IC and IR (End: -3.4 ± 2.2 s-1, Mid: -1.8 ± 1.5 s-1 Epi: -0.63 ± 1.0 s-1, p <0.0001 during IC; End: 2.2 ± 1.5 s-1, Mid: 1.0 ± 0.8 s-1, Epi: 0.47 ± 0.64 s-1, p <0.0001 during IR). Also, SRs of the End and Mid layers during IC were significantly altered by different hemodynamic conditions (End at baseline: 1.7 ± 0.7 s-1; blood: 2.0 ± 1.1 s -1; dobutamine: 3.4 ± 2.3 s-1; metoprolol: 1.0 ± 0.4 s-1; p <0.05). Myocardial strain showed differences in each layer (End: -34.3 ± 12.6%; Mid: -22.6 ± 12.1%; Epi: -11.4 ± 7.9%; p <0.0001) and changed significantly in different hemodynamic conditions (p <0.0001). CONCLUSIONS: Strain and SR appear useful and sensitive for evaluating myocardial function, especially for the subendocardial region.

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