Myocardial perfusion imaging in the setting of coronary artery stenosis and acute myocardial infarction using venous injection of a second-generation echocardiographic contrast agent

Christian Firschke, Jonathan Lindner, Kevin Wei, Norman C. Goodman, Danny M. Skyba, Sanjiv Kaul

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

Background: We hypothesized that by producing excellent myocardial opacification, venous injection of FS-069 coupled with intermittent harmonic imaging (IHI) can be used to determine the presence and severity of coronary stenoses during hyperemia, the size of the risk area during coronary occlusion, and the extent of myocardial salvage after reperfusion. Methods and Results: Twelve dogs were imaged both continuously and intermittently (every end systole) in the fundamental (2 MHz) and harmonic (transmit at 2 and receive at 4 MHz) modes. FS-069 (1 mL) was injected intravenously for all stages and modes of imaging. Myocardial video intensity was severalfold (P

Original languageEnglish (US)
Pages (from-to)959-967
Number of pages9
JournalCirculation
Volume96
Issue number3
StatePublished - Aug 5 1997
Externally publishedYes

Fingerprint

Myocardial Perfusion Imaging
Coronary Stenosis
Contrast Media
Myocardial Infarction
Injections
Systole
Coronary Occlusion
Hyperemia
Reperfusion
Dogs
FS 069

Keywords

  • Contrast media
  • Echocardiography
  • Infarction
  • Occlusion
  • Stenosis

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Myocardial perfusion imaging in the setting of coronary artery stenosis and acute myocardial infarction using venous injection of a second-generation echocardiographic contrast agent",
abstract = "Background: We hypothesized that by producing excellent myocardial opacification, venous injection of FS-069 coupled with intermittent harmonic imaging (IHI) can be used to determine the presence and severity of coronary stenoses during hyperemia, the size of the risk area during coronary occlusion, and the extent of myocardial salvage after reperfusion. Methods and Results: Twelve dogs were imaged both continuously and intermittently (every end systole) in the fundamental (2 MHz) and harmonic (transmit at 2 and receive at 4 MHz) modes. FS-069 (1 mL) was injected intravenously for all stages and modes of imaging. Myocardial video intensity was severalfold (P",
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T1 - Myocardial perfusion imaging in the setting of coronary artery stenosis and acute myocardial infarction using venous injection of a second-generation echocardiographic contrast agent

AU - Firschke, Christian

AU - Lindner, Jonathan

AU - Wei, Kevin

AU - Goodman, Norman C.

AU - Skyba, Danny M.

AU - Kaul, Sanjiv

PY - 1997/8/5

Y1 - 1997/8/5

N2 - Background: We hypothesized that by producing excellent myocardial opacification, venous injection of FS-069 coupled with intermittent harmonic imaging (IHI) can be used to determine the presence and severity of coronary stenoses during hyperemia, the size of the risk area during coronary occlusion, and the extent of myocardial salvage after reperfusion. Methods and Results: Twelve dogs were imaged both continuously and intermittently (every end systole) in the fundamental (2 MHz) and harmonic (transmit at 2 and receive at 4 MHz) modes. FS-069 (1 mL) was injected intravenously for all stages and modes of imaging. Myocardial video intensity was severalfold (P

AB - Background: We hypothesized that by producing excellent myocardial opacification, venous injection of FS-069 coupled with intermittent harmonic imaging (IHI) can be used to determine the presence and severity of coronary stenoses during hyperemia, the size of the risk area during coronary occlusion, and the extent of myocardial salvage after reperfusion. Methods and Results: Twelve dogs were imaged both continuously and intermittently (every end systole) in the fundamental (2 MHz) and harmonic (transmit at 2 and receive at 4 MHz) modes. FS-069 (1 mL) was injected intravenously for all stages and modes of imaging. Myocardial video intensity was severalfold (P

KW - Contrast media

KW - Echocardiography

KW - Infarction

KW - Occlusion

KW - Stenosis

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