Myocardial perfusion and function during acute right ventricular systolic hypertension.

M. Manohar, G. E. Bisgard, V. Bullard, J. A. Will, Debra Anderson, J. H. Rankin

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Hemodynamics, myocardial function, and regional myocardial blood flow (MBF) were measured in 6 closed-chest ponies anesthetized with ketamine hydrochloride before (control) and after creation of acute right ventricular systolic hypertension (RVSH) during normoxia and isocapnic hypoxia. The right ventricular (RV) systolic pressure during each RVSH approached 90 mmHg. There were significant alterations in the pattern of total ventricular MBG distribution in favor of the RV. Because RV myocardium received proportionate increments to its endocardium as well as epicardium, it is concluded that autoregulation in the RV coronary vascular bed had not been abolished even during hypoxia + RVSH. Marked increase in MBF to the right side of the septum during each RVSH with little change in perfusion to other regions suggests that RV contraction is supported by the right side of the septum. Because these increments occurred with decreased RV coronary driving pressure they were the consequence of compensatory coronary vasodilatation. The slow heart rate of the pony in the presence of a large coronary vasodilatory reserve may have been the major factor in allowing large increments in MBF to the stressed regions despite decreased coronary driving pressure.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume235
Issue number6
StatePublished - Dec 1978
Externally publishedYes

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Perfusion
Hypertension
Pressure
Endocardium
Pericardium
Regional Blood Flow
Ketamine
Ventricular Pressure
Vasodilation
Blood Vessels
Myocardium
Homeostasis
Thorax
Heart Rate
Hemodynamics
Blood Pressure
Hypoxia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Manohar, M., Bisgard, G. E., Bullard, V., Will, J. A., Anderson, D., & Rankin, J. H. (1978). Myocardial perfusion and function during acute right ventricular systolic hypertension. The American journal of physiology, 235(6).

Myocardial perfusion and function during acute right ventricular systolic hypertension. / Manohar, M.; Bisgard, G. E.; Bullard, V.; Will, J. A.; Anderson, Debra; Rankin, J. H.

In: The American journal of physiology, Vol. 235, No. 6, 12.1978.

Research output: Contribution to journalArticle

Manohar, M, Bisgard, GE, Bullard, V, Will, JA, Anderson, D & Rankin, JH 1978, 'Myocardial perfusion and function during acute right ventricular systolic hypertension.', The American journal of physiology, vol. 235, no. 6.
Manohar M, Bisgard GE, Bullard V, Will JA, Anderson D, Rankin JH. Myocardial perfusion and function during acute right ventricular systolic hypertension. The American journal of physiology. 1978 Dec;235(6).
Manohar, M. ; Bisgard, G. E. ; Bullard, V. ; Will, J. A. ; Anderson, Debra ; Rankin, J. H. / Myocardial perfusion and function during acute right ventricular systolic hypertension. In: The American journal of physiology. 1978 ; Vol. 235, No. 6.
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