Myocardial Dysfunction in Septic Shock

Richard H. Carmona, Tanny Tsao, Michael Dae, Donald D. Trunkey

    Research output: Contribution to journalArticle

    11 Scopus citations

    Abstract

    • Myocardial depression is a major but poorly understood component of septic shock. This study investigates the morphologic and biochemical abnormalities associated with septic shock. Myocardial cells are incubated in normal and septic plasma in a nutrient-, oxygen-, pH-, electrolyte-, and temperature-controlled environment. Cells and media are tested for basal- and epinephrine-stimulated cyclic adenosine monophosphate (cAMP), lactic dehydrogenase (LDH), and creatine kinase. Electron microscopic studies are done at the end of incubation. Septic LDH and creatine kinase levels in the media are increased substantially, and septic cAMP levels are reduced significantly. Septic cells beat irregularly and arrest along with exhibiting abnormal electron microscopic structure. Septic myocardial dysfunction occurs independently of previously postulated causes that are controlled for in this experiment and therefore may be due to endogenously produced or accumulated toxic factor(s).

    Original languageEnglish (US)
    Pages (from-to)30-35
    Number of pages6
    JournalArchives of Surgery
    Volume120
    Issue number1
    DOIs
    StatePublished - Jan 1985

    ASJC Scopus subject areas

    • Surgery

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