Myocardial Dysfunction in Septic Shock

Richard H. Carmona, Tanny Tsao, Michael Dae, Donald D. Trunkey

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


• Myocardial depression is a major but poorly understood component of septic shock. This study investigates the morphologic and biochemical abnormalities associated with septic shock. Myocardial cells are incubated in normal and septic plasma in a nutrient-, oxygen-, pH-, electrolyte-, and temperature-controlled environment. Cells and media are tested for basal- and epinephrine-stimulated cyclic adenosine monophosphate (cAMP), lactic dehydrogenase (LDH), and creatine kinase. Electron microscopic studies are done at the end of incubation. Septic LDH and creatine kinase levels in the media are increased substantially, and septic cAMP levels are reduced significantly. Septic cells beat irregularly and arrest along with exhibiting abnormal electron microscopic structure. Septic myocardial dysfunction occurs independently of previously postulated causes that are controlled for in this experiment and therefore may be due to endogenously produced or accumulated toxic factor(s).

Original languageEnglish (US)
Pages (from-to)30-35
Number of pages6
JournalArchives of Surgery
Issue number1
StatePublished - Jan 1985
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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