Myocardial depression in sepsis

James Raffa, Donald D. Trunkey

    Research output: Contribution to journalArticlepeer-review

    16 Scopus citations


    Myocardial failure is uniformly fatal when associated with post-traumatic sepsis and multisystem failure. Controversy exists as to whether endotoxin has a direct effect on the myocardium. A nonanoxic isolated arterially perfused rabbit interventicular septum was used in this study to evaluate the effects of endotoxin, live E. coli, and endotoxin/septic shock plasma on myocardial function and ultrastructure. Purified E. coli endotoxin and live E. coli bacteria did not have a significant direct effect on rabbit cardiac muscle function or ultrastructure. Perfusion of the rabbit septum with plasma from rabbits exsanguinated following a 2-hour septic or endotoxin shock insult, however, caused significant (p < 0.02) myocardial depression when compared with control septa perfused with normal rabbit plasma. Septa perfused with shock plasma demonstrated ultrastructural alterations of mitochondria that were not noted in control preparations.

    Original languageEnglish (US)
    Number of pages1
    JournalJournal of Trauma - Injury, Infection and Critical Care
    Issue number9
    StatePublished - Sep 1978

    ASJC Scopus subject areas

    • Surgery
    • Critical Care and Intensive Care Medicine


    Dive into the research topics of 'Myocardial depression in sepsis'. Together they form a unique fingerprint.

    Cite this