TY - JOUR
T1 - Myocardial contrast echocardiography without significant hemodynamic effects or reactive hyperemia
T2 - A major advantage in the imaging of regional myocardial perfusion
AU - Keller, Mark W.
AU - Glasheen, William
AU - Teja, Kuldeep
AU - Gear, Adrian
AU - Kaul, Sanjiv
PY - 1988/10
Y1 - 1988/10
N2 - All agents used for myocardial contrast echocardiography to date produce adverse hemodynamic effects and alter coronary blood flow. It was hypothesized that because 5% human albumin, when sonicated for use as a contrast agent, is neither hyperosmolar nor a calcium chelator, it would not have significant effects on coronary blood flow, left ventricular function or systemic hemodynamics. Albumin microbubbles of two distinct sizes (mean size 2.9 and 5.8 μm) were produced and compared with nonsonicated albumin, nonsonicated Renografin, sonicated Renografin and hand-agitated Renografin for their effects on hemodynamics, coronary mood flow and regional left ventricular systolic thickening in 15 open chest anesthetized dogs. None of the albumin solutions significantly altered left atrial, left ventricular systolic and end-diastolic and mean aortic pressures. These agents did not cause a coronary hyperemic response or alter left ventricular systolic thickening, but slightly lowered the peak positive left ventricular maximal rate of rise in pressure ( dP dt) (-4.1 ± 5.4%, p < 0.01). In contrast, all the Renografin solutions caused significant changes in all these variables (p < 0.02). In six dogs, albumin solutions did not alter these variables even in the presence of critical coronary stenosis. The contrast opacification produced by 5.8 μm albumin microbubbles was equivalent to that produced by sonicated Renografin. Compared with an equivalent amount of saline and nonsonicated albumin solutions, 10 ml of sonicated albumin did not produce any evidence of infarction, embolization or hemorrhage in the myocardium, brain or kidneys of rabbits. In conclusion, intracoronary injection of sonicated albumin does not alter coronary blood flow, left ventricular function or systemic hemodynamics, offering a major advantage in the imaging of regional myocardial perfusion.
AB - All agents used for myocardial contrast echocardiography to date produce adverse hemodynamic effects and alter coronary blood flow. It was hypothesized that because 5% human albumin, when sonicated for use as a contrast agent, is neither hyperosmolar nor a calcium chelator, it would not have significant effects on coronary blood flow, left ventricular function or systemic hemodynamics. Albumin microbubbles of two distinct sizes (mean size 2.9 and 5.8 μm) were produced and compared with nonsonicated albumin, nonsonicated Renografin, sonicated Renografin and hand-agitated Renografin for their effects on hemodynamics, coronary mood flow and regional left ventricular systolic thickening in 15 open chest anesthetized dogs. None of the albumin solutions significantly altered left atrial, left ventricular systolic and end-diastolic and mean aortic pressures. These agents did not cause a coronary hyperemic response or alter left ventricular systolic thickening, but slightly lowered the peak positive left ventricular maximal rate of rise in pressure ( dP dt) (-4.1 ± 5.4%, p < 0.01). In contrast, all the Renografin solutions caused significant changes in all these variables (p < 0.02). In six dogs, albumin solutions did not alter these variables even in the presence of critical coronary stenosis. The contrast opacification produced by 5.8 μm albumin microbubbles was equivalent to that produced by sonicated Renografin. Compared with an equivalent amount of saline and nonsonicated albumin solutions, 10 ml of sonicated albumin did not produce any evidence of infarction, embolization or hemorrhage in the myocardium, brain or kidneys of rabbits. In conclusion, intracoronary injection of sonicated albumin does not alter coronary blood flow, left ventricular function or systemic hemodynamics, offering a major advantage in the imaging of regional myocardial perfusion.
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U2 - 10.1016/0735-1097(88)90474-3
DO - 10.1016/0735-1097(88)90474-3
M3 - Article
C2 - 3417978
AN - SCOPUS:0023801551
SN - 0735-1097
VL - 12
SP - 1039
EP - 1047
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 4
ER -