Myeloid-Derived Suppressor Cell Membrane-Coated Magnetic Nanoparticles for Cancer Theranostics by Inducing Macrophage Polarization and Synergizing Immunogenic Cell Death

Guang Tao Yu, Lang Rao, Hao Wu, Lei Lei Yang, Lin Lin Bu, Wei Wei Deng, Lei Wu, Xiaolin Nan, Wen Feng Zhang, Xing Zhong Zhao, Wei Liu, Zhi Jun Sun

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A major challenge for traditional cancer therapy, including surgical resection, chemoradiotherapy, and immunotherapy, is how to induce tumor cell death and leverage the host immune system at the same time. Here, a myeloid-derived suppressor cell (MDSC) membrane-coated iron oxide magnetic nanoparticle (MNP@MDSC) to overcome this conundrum for cancer therapy is developed. In this study, MNP@MDSC demonstrates its superior performance in immune evasion, active tumor-targeting, magnetic resonance imaging, and photothermal therapy (PTT)-induced tumor killing. Compared with red blood cell membrane-coated nanoparticles (MNPs@RBC) or naked MNPs, MNP@MDSCs are much more effective in active tumor-targeting, a beneficial property afforded by coating MNP with membranes from naturally occurring MDSC, thus converting the MNP into “smart” agents that like to accumulate in tumors as the source MDSCs. Once targeted to the tumor microenvironment, MNPs@MDSC can act as a PTT agents for enhanced antitumor response by inducing immunogenic cell death, reprogramming the tumor infiltrating macrophages, and reducing the tumor's metabolic activity. These benefits, in combination with the excellent biocompatibility and pharmacological kinetics characteristics, make MNP@MDSC a promising, multimodal agent for cancer theranostics.

Original languageEnglish (US)
Article number1801389
JournalAdvanced Functional Materials
Volume28
Issue number37
DOIs
StatePublished - Sep 12 2018

Fingerprint

suppressors
macrophages
Macrophages
Cell death
Cell membranes
death
Tumors
tumors
cancer
Polarization
Nanoparticles
nanoparticles
polarization
therapy
cells
Chemoradiotherapy
immune systems
Immune system
erythrocytes
biocompatibility

Keywords

  • immunogenic cell death
  • macrophage
  • magnetic resonance imaging
  • myeloid-derived suppressor cell
  • photothermal therapy

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Myeloid-Derived Suppressor Cell Membrane-Coated Magnetic Nanoparticles for Cancer Theranostics by Inducing Macrophage Polarization and Synergizing Immunogenic Cell Death. / Yu, Guang Tao; Rao, Lang; Wu, Hao; Yang, Lei Lei; Bu, Lin Lin; Deng, Wei Wei; Wu, Lei; Nan, Xiaolin; Zhang, Wen Feng; Zhao, Xing Zhong; Liu, Wei; Sun, Zhi Jun.

In: Advanced Functional Materials, Vol. 28, No. 37, 1801389, 12.09.2018.

Research output: Contribution to journalArticle

Yu, Guang Tao ; Rao, Lang ; Wu, Hao ; Yang, Lei Lei ; Bu, Lin Lin ; Deng, Wei Wei ; Wu, Lei ; Nan, Xiaolin ; Zhang, Wen Feng ; Zhao, Xing Zhong ; Liu, Wei ; Sun, Zhi Jun. / Myeloid-Derived Suppressor Cell Membrane-Coated Magnetic Nanoparticles for Cancer Theranostics by Inducing Macrophage Polarization and Synergizing Immunogenic Cell Death. In: Advanced Functional Materials. 2018 ; Vol. 28, No. 37.
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