Abstract
Raised percentage hypochromic red cells (%HRC) were detected at diagnosis in 10 of 34 consecutive patients with low-risk myelodysplastic syndrome (MDS) [refractory anemia (RA) (4/26) and RA with ring sideroblasts (6/8)], all of whom had normal or increased serum ferritin and bone marrow iron stores. Elevated %HRC has persisted in all 10 cases and subsequently developed in another RA patient who later had a complete remission of MDS with normalisation of %HRC after a respiratory tract infection. A strong positive correlation was found between %HRC and erythrocyte zinc protoporphyrin levels in 11 MDS patients tested (p=0.01), suggesting that functional iron deficiency contributes to ineffective erythropoiesis in cases of MDS with raised %HRC. Five of seven patients with elevated %HRC had satisfactory haemoglobin responses to a trial of human recombinant erythropoietin without iron supplementation.
Original language | English (US) |
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Pages (from-to) | 455-457 |
Number of pages | 3 |
Journal | Annals of hematology |
Volume | 85 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2006 |
Externally published | Yes |
Keywords
- Erythrocyte zinc protoporphyrin
- Erythropoietin
- Myelodysplastic syndrome
- Percentage hypochromic red cells
ASJC Scopus subject areas
- Hematology