Myelodysplasia and Acute Leukemia as Late Complications of Marrow Failure: Future Prospects for Leukemia Prevention

    Research output: Contribution to journalReview article

    14 Scopus citations


    Patients who have acquired and inherited bone marrow failure syndromes are at risk for the development of clonal neoplasms including acute myeloid leukemia, myelodysplastic syndrome, and paroxysmal nocturnal hemoglobinuria. This article reviews the evidence supporting a model of clonal selection, a paradigm that provides a reasonable expectation that these often fatal complications might be prevented in the future.

    Original languageEnglish (US)
    Pages (from-to)361-376
    Number of pages16
    JournalHematology/Oncology Clinics of North America
    Issue number2
    StatePublished - Apr 1 2009



    • Aplastic anemia
    • Apoptosis
    • Clonal evolution
    • Fanconi's anemia
    • Leukemogenesis
    • Myelodysplasia
    • Natural selection

    ASJC Scopus subject areas

    • Hematology
    • Oncology

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