Myelodysplasia and Acute Leukemia as Late Complications of Marrow Failure: Future Prospects for Leukemia Prevention

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    14 Citations (Scopus)

    Abstract

    Patients who have acquired and inherited bone marrow failure syndromes are at risk for the development of clonal neoplasms including acute myeloid leukemia, myelodysplastic syndrome, and paroxysmal nocturnal hemoglobinuria. This article reviews the evidence supporting a model of clonal selection, a paradigm that provides a reasonable expectation that these often fatal complications might be prevented in the future.

    Original languageEnglish (US)
    Pages (from-to)361-376
    Number of pages16
    JournalHematology/Oncology Clinics of North America
    Volume23
    Issue number2
    DOIs
    StatePublished - Apr 2009

    Fingerprint

    Paroxysmal Hemoglobinuria
    Myelodysplastic Syndromes
    Acute Myeloid Leukemia
    Leukemia
    Bone Marrow
    Neoplasms
    Bone Marrow failure syndromes

    Keywords

    • Aplastic anemia
    • Apoptosis
    • Clonal evolution
    • Fanconi's anemia
    • Leukemogenesis
    • Myelodysplasia
    • Natural selection

    ASJC Scopus subject areas

    • Oncology
    • Hematology

    Cite this

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    abstract = "Patients who have acquired and inherited bone marrow failure syndromes are at risk for the development of clonal neoplasms including acute myeloid leukemia, myelodysplastic syndrome, and paroxysmal nocturnal hemoglobinuria. This article reviews the evidence supporting a model of clonal selection, a paradigm that provides a reasonable expectation that these often fatal complications might be prevented in the future.",
    keywords = "Aplastic anemia, Apoptosis, Clonal evolution, Fanconi's anemia, Leukemogenesis, Myelodysplasia, Natural selection",
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    KW - Natural selection

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