Myelodysplasia and Acute Leukemia as Late Complications of Marrow Failure: Future Prospects for Leukemia Prevention

Grover C. Bagby, Gabrielle Meyers

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Patients who have acquired and inherited bone marrow failure syndromes are at risk for the development of clonal neoplasms including acute myeloid leukemia, myelodysplastic syndrome, and paroxysmal nocturnal hemoglobinuria. This article reviews the evidence supporting a model of clonal selection, a paradigm that provides a reasonable expectation that these often fatal complications might be prevented in the future.

Original languageEnglish (US)
Pages (from-to)361-376
Number of pages16
JournalHematology/Oncology Clinics of North America
Volume23
Issue number2
DOIs
StatePublished - Apr 2009

Keywords

  • Aplastic anemia
  • Apoptosis
  • Clonal evolution
  • Fanconi's anemia
  • Leukemogenesis
  • Myelodysplasia
  • Natural selection

ASJC Scopus subject areas

  • Hematology
  • Oncology

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