Myelodysplasia and Acute Leukemia as Late Complications of Marrow Failure: Future Prospects for Leukemia Prevention

Grover C. Bagby; Gabrielle Meyers

doi:10.1016/j.hoc.2009.01.006

Myelodysplasia and Acute Leukemia as Late Complications of Marrow Failure: Future Prospects for Leukemia Prevention

Grover C. Bagby, Gabrielle Meyers

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Patients who have acquired and inherited bone marrow failure syndromes are at risk for the development of clonal neoplasms including acute myeloid leukemia, myelodysplastic syndrome, and paroxysmal nocturnal hemoglobinuria. This article reviews the evidence supporting a model of clonal selection, a paradigm that provides a reasonable expectation that these often fatal complications might be prevented in the future.

Original language	English (US)
Pages (from-to)	361-376
Number of pages	16
Journal	Hematology/Oncology Clinics of North America
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/j.hoc.2009.01.006
State	Published - Apr 2009

Keywords

Aplastic anemia
Apoptosis
Clonal evolution
Fanconi's anemia
Leukemogenesis
Myelodysplasia
Natural selection

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.hoc.2009.01.006

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title = "Myelodysplasia and Acute Leukemia as Late Complications of Marrow Failure: Future Prospects for Leukemia Prevention",

abstract = "Patients who have acquired and inherited bone marrow failure syndromes are at risk for the development of clonal neoplasms including acute myeloid leukemia, myelodysplastic syndrome, and paroxysmal nocturnal hemoglobinuria. This article reviews the evidence supporting a model of clonal selection, a paradigm that provides a reasonable expectation that these often fatal complications might be prevented in the future.",

keywords = "Aplastic anemia, Apoptosis, Clonal evolution, Fanconi's anemia, Leukemogenesis, Myelodysplasia, Natural selection",

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AU - Meyers, Gabrielle

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AB - Patients who have acquired and inherited bone marrow failure syndromes are at risk for the development of clonal neoplasms including acute myeloid leukemia, myelodysplastic syndrome, and paroxysmal nocturnal hemoglobinuria. This article reviews the evidence supporting a model of clonal selection, a paradigm that provides a reasonable expectation that these often fatal complications might be prevented in the future.

KW - Aplastic anemia

KW - Apoptosis

KW - Clonal evolution

KW - Fanconi's anemia

KW - Leukemogenesis

KW - Myelodysplasia

KW - Natural selection

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Myelodysplasia and Acute Leukemia as Late Complications of Marrow Failure: Future Prospects for Leukemia Prevention

Abstract

Keywords

ASJC Scopus subject areas

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