Myelinated and unmyelinated baroreceptors: analysis of differential encoding properties

J. H. Schild, K. D. Alfrey, J. W. Clark, D. L. Kmizo, Michael Andresen

Research output: Contribution to journalArticle

Abstract

Arterial baroreceplor (UK) activity is highly dependent upon fiber type. Measures of slope and gain as well as baseline activity relative to normal ar terial pressures ( P ) exhibit a spectrum of variability far more heterogeneous for unmyelinated j('-tvpe) than for myeliiiaied (A-tvpe) Bits. 1 he biological factors responsible for these differences are not well understood. Keren! voltage clamp dat.a from our lab indicates a strong correlaiion between ih defer minlstic nature of the equations it is not possible to model the variability in discharge frequency often observed in single fiber BR recordings, a character istir that is also more irregular for ('- than A-type Bits. However, we are able 1 o test the potential contributions of a variety of factors un deriving the rather disparate encoding properties exhibited by ('- and A-type BRs. l'or exam pie. differences across a population of BR libers appear to be related to ion channel kinetics while the intrinsic variability exhibited by a single BK fiber is likely a function of mechanical properties (e.g. coupling, structure) of the terminal ending. This work is part of an integrative effort investigating the signal processing aspects associated with the afferent limb of the barorecepior reflex.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996
Externally publishedYes

Fingerprint

Pressoreceptors
Biological Factors
Ion Channels
Reflex
dietary fiber
Extremities
Pressure
Fibers
Population
pies
Clamping devices
ion channels
limbs (animal)
reflexes
mechanical properties
Signal processing
kinetics
Mechanical properties
Kinetics
Electric potential

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Myelinated and unmyelinated baroreceptors : analysis of differential encoding properties. / Schild, J. H.; Alfrey, K. D.; Clark, J. W.; Kmizo, D. L.; Andresen, Michael.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

Schild, J. H. ; Alfrey, K. D. ; Clark, J. W. ; Kmizo, D. L. ; Andresen, Michael. / Myelinated and unmyelinated baroreceptors : analysis of differential encoding properties. In: FASEB Journal. 1996 ; Vol. 10, No. 3.
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