Myelin restoration

Progress and prospects for human cell replacement therapies

Gregory Potter, David H. Rowitch, Magdalena Petryniak

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Oligodendrocytes are the primary source of myelin in the adult central nervous system (CNS), and their dysfunction or loss underlies several diseases of both children and adults. Dysmyelinating and demyelinating diseases are thus attractive targets for cell-based strategies since replacement of a single presumably homogeneous cell type has the potential to restore functional levels of myelin. To understand the obstacles that cell-replacement therapy might face, we review oligodendrocyte biology and emphasize aspects of oligodendrocyte development that will need to be recapitulated by exogenously transplanted cells, including migration from the site of transplantation, axon recognition, terminal differentiation, axon wrapping, and myelin production and maintenance. We summarize studies in which different types of myelin-forming cells have been transplanted into the CNS and highlight the continuing challenges regarding the use of cell-based therapies for human white matter disorders.

Original languageEnglish (US)
Pages (from-to)179-193
Number of pages15
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume59
Issue number3
DOIs
StatePublished - Jun 2011
Externally publishedYes

Fingerprint

Myelin Sheath
Cell- and Tissue-Based Therapy
Oligodendroglia
Central Nervous System
Presynaptic Terminals
Demyelinating Diseases
Cell Movement
Axons
Transplantation
Maintenance

Keywords

  • Cell-replacement
  • Development
  • Leukodystrophy
  • Myelin
  • Oligodendrocyte
  • Pelizaeus-Merzbacher disease
  • Transplantation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Myelin restoration : Progress and prospects for human cell replacement therapies. / Potter, Gregory; Rowitch, David H.; Petryniak, Magdalena.

In: Archivum Immunologiae et Therapiae Experimentalis, Vol. 59, No. 3, 06.2011, p. 179-193.

Research output: Contribution to journalArticle

Potter, Gregory ; Rowitch, David H. ; Petryniak, Magdalena. / Myelin restoration : Progress and prospects for human cell replacement therapies. In: Archivum Immunologiae et Therapiae Experimentalis. 2011 ; Vol. 59, No. 3. pp. 179-193.
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