Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in buffalo rats

Richard E. Jones; Dennis N. Bourdette; Halina Offner; Arthur A. Vandenbark

doi:10.1016/0165-5728(90)90053-P

Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in buffalo rats

Richard E. Jones, Dennis N. Bourdette, Halina Offner, Arthur A. Vandenbark

Neurology

Research output: Contribution to journal › Article

14 Scopus citations

Abstract

This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1^b) following techniques used to develop similar lines from Lewis rats (Rt-1^l). Unlike those of Lewis those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines, Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses.

Original language	English (US)
Pages (from-to)	61-69
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/0165-5728(90)90053-P
State	Published - Nov 1990

Keywords

(Buffalo rat)
Demyelination
Experimental autoimmune encephalomyelitis
Passive immunization

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/0165-5728(90)90053-P

Fingerprint Dive into the research topics of 'Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in buffalo rats'. Together they form a unique fingerprint.

Cite this

Jones, R. E., Bourdette, D. N., Offner, H., & Vandenbark, A. A. (1990). Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in buffalo rats. Journal of Neuroimmunology, 30(1), 61-69. https://doi.org/10.1016/0165-5728(90)90053-P

@article{06035b66e9ca477e99b161f83dcfb6cc,

title = "Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in buffalo rats",

abstract = "This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1b) following techniques used to develop similar lines from Lewis rats (Rt-1l). Unlike those of Lewis those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines, Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses.",

keywords = "(Buffalo rat), Demyelination, Experimental autoimmune encephalomyelitis, Passive immunization",

author = "Jones, {Richard E.} and Bourdette, {Dennis N.} and Halina Offner and Vandenbark, {Arthur A.}",

year = "1990",

month = nov,

doi = "10.1016/0165-5728(90)90053-P",

language = "English (US)",

volume = "30",

pages = "61--69",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in buffalo rats

AU - Jones, Richard E.

AU - Bourdette, Dennis N.

AU - Offner, Halina

AU - Vandenbark, Arthur A.

PY - 1990/11

Y1 - 1990/11

N2 - This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1b) following techniques used to develop similar lines from Lewis rats (Rt-1l). Unlike those of Lewis those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines, Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses.

AB - This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1b) following techniques used to develop similar lines from Lewis rats (Rt-1l). Unlike those of Lewis those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines, Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses.

KW - (Buffalo rat)

KW - Demyelination

KW - Experimental autoimmune encephalomyelitis

KW - Passive immunization

UR - http://www.scopus.com/inward/record.url?scp=0025064527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025064527&partnerID=8YFLogxK

U2 - 10.1016/0165-5728(90)90053-P

DO - 10.1016/0165-5728(90)90053-P

M3 - Article

C2 - 1699972

AN - SCOPUS:0025064527

VL - 30

SP - 61

EP - 69

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1

ER -