Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in buffalo rats

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14 Scopus citations

Abstract

This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1b) following techniques used to develop similar lines from Lewis rats (Rt-1l). Unlike those of Lewis those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines, Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalJournal of Neuroimmunology
Volume30
Issue number1
DOIs
StatePublished - Nov 1990

Keywords

  • (Buffalo rat)
  • Demyelination
  • Experimental autoimmune encephalomyelitis
  • Passive immunization

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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