Abstract
This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1b) following techniques used to develop similar lines from Lewis rats (Rt-1l). Unlike those of Lewis those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines, Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 61-69 |
| Number of pages | 9 |
| Journal | Journal of Neuroimmunology |
| Volume | 30 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1990 |
Fingerprint
Keywords
- (Buffalo rat)
- Demyelination
- Experimental autoimmune encephalomyelitis
- Passive immunization
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Clinical Neurology
- Neurology
Cite this
Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in buffalo rats. / Jones, Richard E.; Bourdette, Dennis; Offner, Halina; Vandenbark, Arthur.
In: Journal of Neuroimmunology, Vol. 30, No. 1, 1990, p. 61-69.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in buffalo rats
AU - Jones, Richard E.
AU - Bourdette, Dennis
AU - Offner, Halina
AU - Vandenbark, Arthur
PY - 1990
Y1 - 1990
N2 - This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1b) following techniques used to develop similar lines from Lewis rats (Rt-1l). Unlike those of Lewis those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines, Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses.
AB - This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1b) following techniques used to develop similar lines from Lewis rats (Rt-1l). Unlike those of Lewis those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines, Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses.
KW - (Buffalo rat)
KW - Demyelination
KW - Experimental autoimmune encephalomyelitis
KW - Passive immunization
UR - http://www.scopus.com/inward/record.url?scp=0025064527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025064527&partnerID=8YFLogxK
U2 - 10.1016/0165-5728(90)90053-P
DO - 10.1016/0165-5728(90)90053-P
M3 - Article
C2 - 1699972
AN - SCOPUS:0025064527
VL - 30
SP - 61
EP - 69
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1
ER -