Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in buffalo rats

Richard E. Jones; Dennis N. Bourdette; Halina Offner; Arthur A. Vandenbark

doi:10.1016/0165-5728(90)90053-P

Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in buffalo rats

Richard E. Jones, Dennis N. Bourdette, Halina Offner, Arthur A. Vandenbark

Neurology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1^b) following techniques used to develop similar lines from Lewis rats (Rt-1^l). Unlike those of Lewis those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines, Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses.

Original language	English (US)
Pages (from-to)	61-69
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/0165-5728(90)90053-P
State	Published - Nov 1990

Keywords

(Buffalo rat)
Demyelination
Experimental autoimmune encephalomyelitis
Passive immunization

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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title = "Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in buffalo rats",

abstract = "This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1b) following techniques used to develop similar lines from Lewis rats (Rt-1l). Unlike those of Lewis those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines, Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses.",

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