TY - JOUR
T1 - Mycosis Fungoides
T2 - Intraocular and Central Nervous System Involvement
AU - Keltner, John L.
AU - Fritsch, Esther
AU - Cykiert, Robert C.
AU - Albert, Daniel M.
PY - 1977/4
Y1 - 1977/4
N2 - A 58-year-old man with mycosis fungoides was treated with chemotherapeutic agents and radiation for the recurrent cutaneous form of this disease. Five years after the onset, he developed blurring of vision, neurologic signs, and then lapsed into coma. Chemotherapy and radiation treatment resulted in improvement of the ocular and systemic picture. Within three months, however, the patient's vision deteriorated and swelling of both optic discs, along with retinal and vitreous infiltrates, was noted. Local radiation of the eyes was followed by improvement of the ocular changes. Five months later the patient died. Results of a histologic examination of the eyes showed extensive involvement of the retina and vitreous by tumor cells. The CNS was remarkably free of tumor cells and it was assumed that the radiation and chemotherapy were responsible for this.
AB - A 58-year-old man with mycosis fungoides was treated with chemotherapeutic agents and radiation for the recurrent cutaneous form of this disease. Five years after the onset, he developed blurring of vision, neurologic signs, and then lapsed into coma. Chemotherapy and radiation treatment resulted in improvement of the ocular and systemic picture. Within three months, however, the patient's vision deteriorated and swelling of both optic discs, along with retinal and vitreous infiltrates, was noted. Local radiation of the eyes was followed by improvement of the ocular changes. Five months later the patient died. Results of a histologic examination of the eyes showed extensive involvement of the retina and vitreous by tumor cells. The CNS was remarkably free of tumor cells and it was assumed that the radiation and chemotherapy were responsible for this.
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U2 - 10.1001/archopht.1977.04450040111017
DO - 10.1001/archopht.1977.04450040111017
M3 - Article
C2 - 849188
AN - SCOPUS:0017595573
SN - 0003-9950
VL - 95
SP - 645
EP - 650
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 4
ER -