MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia

Alfredo Rodríguez, Kaiyang Zhang, Anniina Färkkilä, Jessica Filiatrault, Chunyu Yang, Martha Velázquez, Elissa Furutani, Devorah C. Goldman, Benilde García de Teresa, Gilda Garza-Mayén, Kelsey McQueen, Larissa A. Sambel, Bertha Molina, Leda Torres, Marisol González, Eduardo Vadillo, Rosana Pelayo, William H. Fleming, Markus Grompe, Akiko ShimamuraSampsa Hautaniemi, Joel Greenberger, Sara Frías, Kalindi Parmar, Alan D. D'Andrea

Research output: Contribution to journalArticlepeer-review

Abstract

Rodríguez et al. demonstrate that MYC is upregulated in hematopoietic stem and progenitor cells (HSPCs) from Fanconi anemia (FA) patients. On the one hand, MYC counteracts p53- and TGF-β-mediated growth suppression in FA bone marrow. On the other hand, MYC expression worsens replicative and genotoxic stress of FA HSPCs.

Original languageEnglish (US)
JournalCell Stem Cell
DOIs
StateAccepted/In press - 2020

Keywords

  • bone marrow failure
  • CXCR4
  • DNA damage
  • Fanconi anemia
  • genotoxic stress
  • hematopoietic stem cells
  • MYC
  • p53
  • physiological stress
  • single-cell RNA sequencing

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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