Myc-driven murine prostate cancer shares molecular features with human prostate tumors

Katharine Ellwood-Yen, Thomas G. Graeber, John Wongvipat, M. Luisa Iruela-Arispe, JianFeng Zhang, Robert Matusik, George Thomas, Charles L. Sawyers

Research output: Contribution to journalArticle

506 Citations (Scopus)

Abstract

Increased Myc gene copy number is observed in human prostate cancer. To define Myc's functional role, we generated transgenic mice expressing human c-Myc in the mouse prostate. All mice developed murine prostatic intraepithelial neoplasia followed by invasive adenocarcinoma. Microarray-based expression profiling identified a Myc prostate cancer expression signature, which included the putative human tumor suppressor NXK3.1. Human prostate tumor databases revealed modules of human genes that varied in concert with the Myc prostate cancer signature. This module includes the Pim-1 kinase, a gene known to cooperate with Myc in tumorigenesis, and defines a subset of human, "Myc-like" human cancers. This approach illustrates how genomic technologies can be applied to mouse cancer models to guide evaluation of human tumor databases.

Original languageEnglish (US)
Pages (from-to)223-238
Number of pages16
JournalCancer Cell
Volume4
Issue number3
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

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Prostate
Prostatic Neoplasms
Neoplasms
Proto-Oncogene Proteins c-pim-1
Databases
Prostatic Intraepithelial Neoplasia
myc Genes
Gene Dosage
Gene Regulatory Networks
Transgenic Mice
Carcinogenesis
Adenocarcinoma
Technology
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Ellwood-Yen, K., Graeber, T. G., Wongvipat, J., Iruela-Arispe, M. L., Zhang, J., Matusik, R., ... Sawyers, C. L. (2003). Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell, 4(3), 223-238. https://doi.org/10.1016/S1535-6108(03)00197-1

Myc-driven murine prostate cancer shares molecular features with human prostate tumors. / Ellwood-Yen, Katharine; Graeber, Thomas G.; Wongvipat, John; Iruela-Arispe, M. Luisa; Zhang, JianFeng; Matusik, Robert; Thomas, George; Sawyers, Charles L.

In: Cancer Cell, Vol. 4, No. 3, 01.09.2003, p. 223-238.

Research output: Contribution to journalArticle

Ellwood-Yen, K, Graeber, TG, Wongvipat, J, Iruela-Arispe, ML, Zhang, J, Matusik, R, Thomas, G & Sawyers, CL 2003, 'Myc-driven murine prostate cancer shares molecular features with human prostate tumors', Cancer Cell, vol. 4, no. 3, pp. 223-238. https://doi.org/10.1016/S1535-6108(03)00197-1
Ellwood-Yen K, Graeber TG, Wongvipat J, Iruela-Arispe ML, Zhang J, Matusik R et al. Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell. 2003 Sep 1;4(3):223-238. https://doi.org/10.1016/S1535-6108(03)00197-1
Ellwood-Yen, Katharine ; Graeber, Thomas G. ; Wongvipat, John ; Iruela-Arispe, M. Luisa ; Zhang, JianFeng ; Matusik, Robert ; Thomas, George ; Sawyers, Charles L. / Myc-driven murine prostate cancer shares molecular features with human prostate tumors. In: Cancer Cell. 2003 ; Vol. 4, No. 3. pp. 223-238.
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