Myc-driven murine prostate cancer shares molecular features with human prostate tumors

Katharine Ellwood-Yen, Thomas G. Graeber, John Wongvipat, M. Luisa Iruela-Arispe, Jian Feng Zhang, Robert Matusik, George V. Thomas, Charles L. Sawyers

Research output: Contribution to journalArticle

524 Scopus citations

Abstract

Increased Myc gene copy number is observed in human prostate cancer. To define Myc's functional role, we generated transgenic mice expressing human c-Myc in the mouse prostate. All mice developed murine prostatic intraepithelial neoplasia followed by invasive adenocarcinoma. Microarray-based expression profiling identified a Myc prostate cancer expression signature, which included the putative human tumor suppressor NXK3.1. Human prostate tumor databases revealed modules of human genes that varied in concert with the Myc prostate cancer signature. This module includes the Pim-1 kinase, a gene known to cooperate with Myc in tumorigenesis, and defines a subset of human, "Myc-like" human cancers. This approach illustrates how genomic technologies can be applied to mouse cancer models to guide evaluation of human tumor databases.

Original languageEnglish (US)
Pages (from-to)223-238
Number of pages16
JournalCancer Cell
Volume4
Issue number3
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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  • Cite this

    Ellwood-Yen, K., Graeber, T. G., Wongvipat, J., Iruela-Arispe, M. L., Zhang, J. F., Matusik, R., Thomas, G. V., & Sawyers, C. L. (2003). Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell, 4(3), 223-238. https://doi.org/10.1016/S1535-6108(03)00197-1