TY - JOUR
T1 - Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src
AU - Barone, M. Vittoria
AU - Courtneidge, Sara A.
PY - 1995/11/30
Y1 - 1995/11/30
N2 - Growth factors such as platelet-derived growth factor (PDGF) elicit the transcriptional activation of a large number of immediate early genes (many of which encode transcription factors), and ultimately DNA synthesis1. Both API and Myc are activated in fibroblasts in response to growth factor stimulation2–5, and various experiments suggest their importance in proliferation6‑10. Src family kinases are required for PDGF (and other growth factors) to induce DNA synthesis11,12. We have examined which transcription factors, when constitutively expressed, 'rescue' the block elicited by dominant negative Src. We report here that Myc, but not Fos and/or Jun, was able to rescue the block. In contrast, Fos and Jun, but not Myc, rescued the block induced by dominant negative Ras. Our data suggest that Src kinases control the transcriptional activation of Myc.
AB - Growth factors such as platelet-derived growth factor (PDGF) elicit the transcriptional activation of a large number of immediate early genes (many of which encode transcription factors), and ultimately DNA synthesis1. Both API and Myc are activated in fibroblasts in response to growth factor stimulation2–5, and various experiments suggest their importance in proliferation6‑10. Src family kinases are required for PDGF (and other growth factors) to induce DNA synthesis11,12. We have examined which transcription factors, when constitutively expressed, 'rescue' the block elicited by dominant negative Src. We report here that Myc, but not Fos and/or Jun, was able to rescue the block. In contrast, Fos and Jun, but not Myc, rescued the block induced by dominant negative Ras. Our data suggest that Src kinases control the transcriptional activation of Myc.
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U2 - 10.1038/378509a0
DO - 10.1038/378509a0
M3 - Article
C2 - 7477410
AN - SCOPUS:0028879873
SN - 0028-0836
VL - 378
SP - 509
EP - 512
JO - Nature
JF - Nature
IS - 6556
ER -