Mutation of three residues in the third intracellular loop of the dopamine D₂ receptor creates an internalization-defective receptor

Medicine & Life Sciences

• Arrestin 100%
• Dopamine D2 Receptors 81%
• Vesicular Transport Adaptor Proteins 61%
• Mutation 38%
• G-Protein-Coupled Receptor Kinase 2 31%
• arrestin3 19%
• Arrestins 16%
• beta-Arrestin 1 16%
• Heterotrimeric GTP-Binding Proteins 13%
• Clathrin 12%
• Alanine 10%
• G-Protein-Coupled Receptors 9%
• GTP-Binding Proteins 9%
• Binding Sites 7%

Chemical Compounds

• Dopamine 64%
• Mutation 58%
• Protein 28%
• Alanine 22%
• Binding Site 16%
• Time 8%