Mutant analysis shows that the Ca2+-induced K+ current shuts off one type of excitation in Paramecium.

Y. Saimi, R. D. Hinrichsen, M. Forte, C. Kung

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Abstract

Two mutants of Paramecium tetraurelia, called "pantophobiacs," were found to lack most of the slow Ca2+-induced K+ outward current. Passive properties, the transient Ca2+ inward current, and the fast depolarization-induced K+ outward current remain normal. The mutant defect reduces the ability to shut off a normal, excited state of the membrane and results in repeated, long backward swimming instead of the wild-type jerks in response to a variety of ions, to heat, and to touch.

Original languageEnglish (US)
Pages (from-to)5112-5116
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume80
Issue number16
DOIs
StatePublished - Aug 1983

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