Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

P. Matthew Joyner; Jinman Liu; Zhijun Zhang; Justin Merritt; Fengxia Qi; Robert H. Cichewicz

doi:10.1039/c0ob00579g

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

P. Matthew Joyner, Jinman Liu, Zhijun Zhang, Justin Merritt, Fengxia Qi, Robert H. Cichewicz

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress tolerance factors. We have now characterized the major compound generated from this gene cluster, mutanobactin A, and demonstrated that this secondary metabolite is also capable of influencing the yeast-mycelium transition of Candida albicans.

Original language	English (US)
Pages (from-to)	5486-5489
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	8
Issue number	24
DOIs	https://doi.org/10.1039/c0ob00579g
State	Published - Dec 21 2010
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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AU - Liu, Jinman

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AU - Merritt, Justin

AU - Qi, Fengxia

AU - Cichewicz, Robert H.

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Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

Abstract

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