Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

P. Matthew Joyner, Jinman Liu, Zhijun Zhang, Justin Merritt, Fengxia Qi, Robert H. Cichewicz

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress tolerance factors. We have now characterized the major compound generated from this gene cluster, mutanobactin A, and demonstrated that this secondary metabolite is also capable of influencing the yeast-mycelium transition of Candida albicans.

Original languageEnglish (US)
Pages (from-to)5486-5489
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume8
Issue number24
DOIs
StatePublished - Dec 21 2010
Externally publishedYes

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streptococcus
Streptococcus mutans
pathogens
metabolites
Mycelium
yeast
regulators
Pathogens
Multigene Family
Metabolites
genes
Yeast
Genes
Yeasts
Candida
Biological Products
Candida albicans
coding
products
mutanobactin A

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition. / Joyner, P. Matthew; Liu, Jinman; Zhang, Zhijun; Merritt, Justin; Qi, Fengxia; Cichewicz, Robert H.

In: Organic and Biomolecular Chemistry, Vol. 8, No. 24, 21.12.2010, p. 5486-5489.

Research output: Contribution to journalArticle

Joyner, P. Matthew ; Liu, Jinman ; Zhang, Zhijun ; Merritt, Justin ; Qi, Fengxia ; Cichewicz, Robert H. / Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition. In: Organic and Biomolecular Chemistry. 2010 ; Vol. 8, No. 24. pp. 5486-5489.
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