Muscarinic receptor antagonists: Effects on pulmonary function

Kalmia S. Buels, Allison D. Fryer

Research output: Chapter in Book/Report/Conference proceedingChapter

47 Scopus citations

Abstract

In healthy lungs, muscarinic receptors control smooth muscle tone, mucus secretion, vasodilation, and inflammation. In chronic obstructive pulmonary disease (COPD) and asthma, cholinergic mechanisms contribute to increased bronchoconstriction and mucus secretion that limit airflow. This chapter reviews neuronal and nonneuronal sources of acetylcholine in the lung and the expression and role of M 1, M 2, and M 3 muscarinic receptor subtypes in lung physiology. It also discusses the evidence for and against the role of parasympathetic nerves in asthma, and the current use and therapeutic potential of muscarinic receptor antagonists in COPD and asthma.

Original languageEnglish (US)
Title of host publicationMuscarinic Receptors
EditorsAllison D. Fryer, Neil M. Nathanson, Arthur Christopoulos
Pages317-341
Number of pages25
DOIs
StatePublished - Feb 10 2012

Publication series

NameHandbook of Experimental Pharmacology
Volume208
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • Asthma
  • Atropine
  • Bronchoconstriction
  • Bronchodilation
  • COPD
  • Hyperresponsiveness
  • Ipratropium
  • Lung
  • Parasympathetic nerves
  • Tiotropium

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Buels, K. S., & Fryer, A. D. (2012). Muscarinic receptor antagonists: Effects on pulmonary function. In A. D. Fryer, N. M. Nathanson, & A. Christopoulos (Eds.), Muscarinic Receptors (pp. 317-341). (Handbook of Experimental Pharmacology; Vol. 208). https://doi.org/10.1007/978-3-642-23274-9_14