Muscarinic receptor antagonists: Effects on pulmonary function

Kalmia S. Buels, Allison Fryer

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

In healthy lungs, muscarinic receptors control smooth muscle tone, mucus secretion, vasodilation, and inflammation. In chronic obstructive pulmonary disease (COPD) and asthma, cholinergic mechanisms contribute to increased bronchoconstriction and mucus secretion that limit airflow. This chapter reviews neuronal and nonneuronal sources of acetylcholine in the lung and the expression and role of M 1, M 2, and M 3 muscarinic receptor subtypes in lung physiology. It also discusses the evidence for and against the role of parasympathetic nerves in asthma, and the current use and therapeutic potential of muscarinic receptor antagonists in COPD and asthma.

Original languageEnglish (US)
Pages (from-to)317-341
Number of pages25
JournalHandbook of Experimental Pharmacology
Volume208
DOIs
Publication statusPublished - 2012

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Keywords

  • Asthma
  • Atropine
  • Bronchoconstriction
  • Bronchodilation
  • COPD
  • Hyperresponsiveness
  • Ipratropium
  • Lung
  • Parasympathetic nerves
  • Tiotropium

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry

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