Muscarinic receptor agonists and antagonists: Effects on inflammation and immunity

Norah G. Verbout, David Jacoby

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In this chapter, we will review what is known about muscarinic regulation of immune cells and the contribution of immune cell muscarinic receptors to inflammatory disease and immunity. In particular, immune cell expression of cholinergic machinery, muscarinic receptor subtypes and functional consequences of agonist stimulation will be reviewed. Lastly, this chapter will discuss the potential therapeutic effects of selective antagonists on immune cell function and inflammatory disease in recent animal studies and human clinical trials.

Original languageEnglish (US)
Pages (from-to)403-427
Number of pages25
JournalHandbook of Experimental Pharmacology
Volume208
DOIs
StatePublished - 2012

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Muscarinic Agonists
Muscarinic Antagonists
Muscarinic Receptors
Cholinergic Agents
Immunity
Inflammation
Machinery
Animals
Therapeutic Uses
Clinical Trials

Keywords

  • Immune cells
  • Inflammatory disease
  • Non-neuronal cholinergic system

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry

Cite this

Muscarinic receptor agonists and antagonists : Effects on inflammation and immunity. / Verbout, Norah G.; Jacoby, David.

In: Handbook of Experimental Pharmacology, Vol. 208, 2012, p. 403-427.

Research output: Contribution to journalArticle

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