Muscarinic receptor agonists and antagonists: Effects on inflammation and immunity

Norah G. Verbout, David B. Jacoby

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

In this chapter, we will review what is known about muscarinic regulation of immune cells and the contribution of immune cell muscarinic receptors to inflammatory disease and immunity. In particular, immune cell expression of cholinergic machinery, muscarinic receptor subtypes and functional consequences of agonist stimulation will be reviewed. Lastly, this chapter will discuss the potential therapeutic effects of selective antagonists on immune cell function and inflammatory disease in recent animal studies and human clinical trials.

Original languageEnglish (US)
Title of host publicationMuscarinic Receptors
EditorsAllison D. Fryer, Neil M. Nathanson, Arthur Christopoulos
Pages403-427
Number of pages25
DOIs
StatePublished - Feb 10 2012

Publication series

NameHandbook of Experimental Pharmacology
Volume208
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • Immune cells
  • Inflammatory disease
  • Non-neuronal cholinergic system

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Verbout, N. G., & Jacoby, D. B. (2012). Muscarinic receptor agonists and antagonists: Effects on inflammation and immunity. In A. D. Fryer, N. M. Nathanson, & A. Christopoulos (Eds.), Muscarinic Receptors (pp. 403-427). (Handbook of Experimental Pharmacology; Vol. 208). https://doi.org/10.1007/978-3-642-23274-9_17